YTFP_ECOLI
ID YTFP_ECOLI Reviewed; 113 AA.
AC P0AE48; P39323; Q2M683;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Gamma-glutamylcyclotransferase family protein YtfP;
GN Name=ytfP; OrderedLocusNames=b4222, JW4181;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=7610040; DOI=10.1093/nar/23.12.2105;
RA Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.;
RT "Analysis of the Escherichia coli genome VI: DNA sequence of the region
RT from 92.8 through 100 minutes.";
RL Nucleic Acids Res. 23:2105-2119(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP STRUCTURE BY NMR, AND PROPOSED FUNCTION.
RX PubMed=17523190; DOI=10.1002/prot.21450;
RA Aramini J.M., Huang Y.J., Swapna G.V., Cort J.R., Rajan P.K., Xiao R.,
RA Shastry R., Acton T.B., Liu J., Rost B., Kennedy M.A., Montelione G.T.;
RT "Solution NMR structure of Escherichia coli YtfP expands the structural
RT coverage of the UPF0131 protein domain family.";
RL Proteins 68:789-795(2007).
CC -!- FUNCTION: May play a role in antibiotic biosynthesis. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the gamma-glutamylcyclotransferase family.
CC {ECO:0000305}.
CC -!- CAUTION: Lacks the conserved Glu residue at position 70 that serves as
CC proton acceptor in enzymes with gamma-glutamylcyclotransferase
CC activity. {ECO:0000305}.
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DR EMBL; U14003; AAA97119.1; -; Genomic_DNA.
DR EMBL; U00096; AAC77179.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE78223.1; -; Genomic_DNA.
DR PIR; S56448; S56448.
DR RefSeq; NP_418643.1; NC_000913.3.
DR RefSeq; WP_001219160.1; NZ_STEB01000013.1.
DR PDB; 1XHS; NMR; -; A=1-113.
DR PDBsum; 1XHS; -.
DR AlphaFoldDB; P0AE48; -.
DR BMRB; P0AE48; -.
DR SMR; P0AE48; -.
DR BioGRID; 4260673; 12.
DR BioGRID; 853032; 1.
DR IntAct; P0AE48; 1.
DR STRING; 511145.b4222; -.
DR jPOST; P0AE48; -.
DR PaxDb; P0AE48; -.
DR PRIDE; P0AE48; -.
DR EnsemblBacteria; AAC77179; AAC77179; b4222.
DR EnsemblBacteria; BAE78223; BAE78223; BAE78223.
DR GeneID; 66671859; -.
DR GeneID; 948741; -.
DR KEGG; ecj:JW4181; -.
DR KEGG; eco:b4222; -.
DR PATRIC; fig|1411691.4.peg.2478; -.
DR EchoBASE; EB2408; -.
DR eggNOG; COG2105; Bacteria.
DR HOGENOM; CLU_083466_5_2_6; -.
DR InParanoid; P0AE48; -.
DR OMA; WIYLYQD; -.
DR PhylomeDB; P0AE48; -.
DR BioCyc; EcoCyc:G7876-MON; -.
DR EvolutionaryTrace; P0AE48; -.
DR PRO; PR:P0AE48; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005829; C:cytosol; IDA:EcoCyc.
DR CDD; cd06661; GGCT_like; 1.
DR InterPro; IPR009288; AIG2-like_dom.
DR InterPro; IPR013024; GGCT-like.
DR InterPro; IPR036568; GGCT-like_sf.
DR Pfam; PF06094; GGACT; 1.
DR SUPFAM; SSF110857; SSF110857; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome.
FT CHAIN 1..113
FT /note="Gamma-glutamylcyclotransferase family protein YtfP"
FT /id="PRO_0000184789"
FT STRAND 2..5
FT /evidence="ECO:0007829|PDB:1XHS"
FT TURN 14..16
FT /evidence="ECO:0007829|PDB:1XHS"
FT HELIX 17..20
FT /evidence="ECO:0007829|PDB:1XHS"
FT STRAND 23..37
FT /evidence="ECO:0007829|PDB:1XHS"
FT STRAND 39..49
FT /evidence="ECO:0007829|PDB:1XHS"
FT STRAND 51..57
FT /evidence="ECO:0007829|PDB:1XHS"
FT HELIX 60..70
FT /evidence="ECO:0007829|PDB:1XHS"
FT STRAND 76..83
FT /evidence="ECO:0007829|PDB:1XHS"
FT STRAND 86..93
FT /evidence="ECO:0007829|PDB:1XHS"
FT STRAND 101..105
FT /evidence="ECO:0007829|PDB:1XHS"
SQ SEQUENCE 113 AA; 12866 MW; A320C9DC94607CF8 CRC64;
MRIFVYGSLR HKQGNSHWMT NAQLLGDFSI DNYQLYSLGH YPGAVPGNGT VHGEVYRIDN
ATLAELDALR TRGGEYARQL IQTPYGSAWM YVYQRPVDGL KLIESGDWLD RDK
