YTFR_ECO57
ID YTFR_ECO57 Reviewed; 500 AA.
AC P63299; P39326; P39327;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Galactofuranose transporter ATP-binding protein YtfR {ECO:0000250|UniProtKB:Q6BEX0};
DE EC=7.5.2.9 {ECO:0000250|UniProtKB:Q6BEX0};
GN Name=ytfR; OrderedLocusNames=Z5839, ECs5206;
OS Escherichia coli O157:H7.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
CC -!- FUNCTION: Part of the ABC transporter complex YtfQRT-YjfF involved in
CC galactofuranose transport. Responsible for energy coupling to the
CC transport system. {ECO:0000250|UniProtKB:Q6BEX0}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-galactofuranose(out) + H2O = ADP + D-
CC galactofuranose(in) + H(+) + phosphate; Xref=Rhea:RHEA:61716,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:143624, ChEBI:CHEBI:456216;
CC EC=7.5.2.9; Evidence={ECO:0000250|UniProtKB:Q6BEX0};
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (YtfR),
CC two transmembrane proteins (YtfT and YjfF) and a solute-binding protein
CC (YtfQ). {ECO:0000250|UniProtKB:Q6BEX0}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:Q6BEX0}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q6BEX0}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR EMBL; AE005174; AAG59426.1; -; Genomic_DNA.
DR EMBL; BA000007; BAB38629.1; -; Genomic_DNA.
DR PIR; F86120; F86120.
DR PIR; F91279; F91279.
DR RefSeq; NP_313233.1; NC_002695.1.
DR RefSeq; WP_000205806.1; NZ_SDVX01000004.1.
DR AlphaFoldDB; P63299; -.
DR SMR; P63299; -.
DR STRING; 155864.EDL933_5575; -.
DR EnsemblBacteria; AAG59426; AAG59426; Z5839.
DR EnsemblBacteria; BAB38629; BAB38629; ECs_5206.
DR GeneID; 913896; -.
DR KEGG; ece:Z5839; -.
DR KEGG; ecs:ECs_5206; -.
DR PATRIC; fig|386585.9.peg.5442; -.
DR eggNOG; COG1129; Bacteria.
DR HOGENOM; CLU_000604_92_3_6; -.
DR Proteomes; UP000000558; Chromosome.
DR Proteomes; UP000002519; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0103116; F:ABC-type D-galactofuranose transporter; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Cell inner membrane; Cell membrane; Membrane;
KW Nucleotide-binding; Reference proteome; Repeat; Sugar transport;
KW Translocase; Transport.
FT CHAIN 1..500
FT /note="Galactofuranose transporter ATP-binding protein
FT YtfR"
FT /id="PRO_0000093176"
FT DOMAIN 10..245
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 259..497
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 42..49
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 500 AA; 55288 MW; 26D0E62D4C62F846 CRC64;
MTTDQHQEIL RTEGLSKFFP GVKALDNVDF SLRRGEIMAL LGENGAGKST LIKALTGVYH
ADRGTIWLEG QAISPKNTAH AQQLGIGTVY QEVNLLPNMS VADNLFIGRE PKRFGLLRRK
EMEKRATELM ASYGFSLDVR EPLNRFSVAM QQIVAICRAI DLSAKVLILD EPTASLDTQE
VELLFDLMRQ LRDRGVSLIF VTHFLDQVYQ VSDRITVLRN GSFVGCRETC ELPQIELVKM
MLGRELDTHA LQRAGRTLLS DKPVAAFKNY GKKGTIAPFD LEVRPGEIVG LAGLLGSGRT
ETAEVIFGIK PADSGTALIK GKPQNLRSPH QASVLGIGFC PEDRKTDGII AAASVRENII
LALQARRGWL RPISRKEQQE IAERFIRQLG IRTPSTEQPI EFLSGGNQQK VLLSRWLLTR
PQFLILDEPT RGIDVGAHAE IIRLIETLCA DGLALLVISS ELEELVGYAD RVIIMRDRKQ
VAEIPLAELS VPAIMNAIAA
