YTFR_ECOLI
ID YTFR_ECOLI Reviewed; 500 AA.
AC Q6BEX0; P39326; P39327; Q2M677;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Galactofuranose transporter ATP-binding protein YtfR {ECO:0000305};
DE EC=7.5.2.9 {ECO:0000305|PubMed:19744923};
GN Name=ytfR; Synonyms=ytfS; OrderedLocusNames=b4485, JW5752;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=7610040; DOI=10.1093/nar/23.12.2105;
RA Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.;
RT "Analysis of the Escherichia coli genome VI: DNA sequence of the region
RT from 92.8 through 100 minutes.";
RL Nucleic Acids Res. 23:2105-2119(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP SEQUENCE REVISION.
RX PubMed=16397293; DOI=10.1093/nar/gkj405;
RA Riley M., Abe T., Arnaud M.B., Berlyn M.K.B., Blattner F.R.,
RA Chaudhuri R.R., Glasner J.D., Horiuchi T., Keseler I.M., Kosuge T.,
RA Mori H., Perna N.T., Plunkett G. III, Rudd K.E., Serres M.H., Thomas G.H.,
RA Thomson N.R., Wishart D., Wanner B.L.;
RT "Escherichia coli K-12: a cooperatively developed annotation snapshot
RT -- 2005.";
RL Nucleic Acids Res. 34:1-9(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP FUNCTION, CATALYTIC ACTIVITY, AND SUBUNIT.
RC STRAIN=K12;
RX PubMed=19744923; DOI=10.1074/jbc.m109.054296;
RA Horler R.S., Muller A., Williamson D.C., Potts J.R., Wilson K.S.,
RA Thomas G.H.;
RT "Furanose-specific sugar transport: characterization of a bacterial
RT galactofuranose-binding protein.";
RL J. Biol. Chem. 284:31156-31163(2009).
CC -!- FUNCTION: Part of the ABC transporter complex YtfQRT-YjfF involved in
CC galactofuranose transport (Probable). Responsible for energy coupling
CC to the transport system (Probable). {ECO:0000305,
CC ECO:0000305|PubMed:19744923}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-galactofuranose(out) + H2O = ADP + D-
CC galactofuranose(in) + H(+) + phosphate; Xref=Rhea:RHEA:61716,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:143624, ChEBI:CHEBI:456216;
CC EC=7.5.2.9; Evidence={ECO:0000305|PubMed:19744923};
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (YtfR),
CC two transmembrane proteins (YtfT and YjfF) and a solute-binding protein
CC (YtfQ). {ECO:0000305|PubMed:19744923}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Peripheral
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA97126.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; U14003; AAA97125.1; ALT_FRAME; Genomic_DNA.
DR EMBL; U14003; AAA97126.1; ALT_FRAME; Genomic_DNA.
DR EMBL; U00096; AAT48244.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE78229.1; -; Genomic_DNA.
DR PIR; S56454; S56454.
DR PIR; S56455; S56455.
DR RefSeq; WP_000205805.1; NZ_LN832404.1.
DR RefSeq; YP_026286.1; NC_000913.3.
DR AlphaFoldDB; Q6BEX0; -.
DR SMR; Q6BEX0; -.
DR BioGRID; 4261872; 25.
DR ComplexPortal; CPX-4323; Galactofuranose ABC transporter complex.
DR DIP; DIP-48183N; -.
DR STRING; 511145.b4485; -.
DR TCDB; 3.A.1.2.25; the atp-binding cassette (abc) superfamily.
DR PaxDb; Q6BEX0; -.
DR PRIDE; Q6BEX0; -.
DR EnsemblBacteria; AAT48244; AAT48244; b4485.
DR EnsemblBacteria; BAE78229; BAE78229; BAE78229.
DR GeneID; 2847725; -.
DR KEGG; ecj:JW5752; -.
DR KEGG; eco:b4485; -.
DR PATRIC; fig|1411691.4.peg.2473; -.
DR EchoBASE; EB2410; -.
DR eggNOG; COG1129; Bacteria.
DR HOGENOM; CLU_000604_92_3_6; -.
DR InParanoid; Q6BEX0; -.
DR OMA; GFGFCPE; -.
DR PhylomeDB; Q6BEX0; -.
DR BioCyc; EcoCyc:YTFR-MON; -.
DR BioCyc; MetaCyc:YTFR-MON; -.
DR PRO; PR:Q6BEX0; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0055052; C:ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing; IC:ComplexPortal.
DR GO; GO:0103116; F:ABC-type D-galactofuranose transporter; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140271; P:hexose import across plasma membrane; IC:ComplexPortal.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 1: Evidence at protein level;
KW ATP-binding; Cell inner membrane; Cell membrane; Membrane;
KW Nucleotide-binding; Reference proteome; Repeat; Sugar transport;
KW Translocase; Transport.
FT CHAIN 1..500
FT /note="Galactofuranose transporter ATP-binding protein
FT YtfR"
FT /id="PRO_0000093175"
FT DOMAIN 10..245
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 259..497
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 42..49
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 500 AA; 55260 MW; 251FE62D4FADF959 CRC64;
MTTDQHQEIL RTEGLSKFFP GVKALDNVDF SLRRGEIMAL LGENGAGKST LIKALTGVYH
ADRGTIWLEG QAISPKNTAH AQQLGIGTVY QEVNLLPNMS VADNLFIGRE PKRFGLLRRK
EMEKRATELM ASYGFSLDVR EPLNRFSVAM QQIVAICRAI DLSAKVLILD EPTASLDTQE
VELLFDLMRQ LRDRGVSLIF VTHFLDQVYQ VSDRITVLRN GSFVGCRETC ELPQIELVKM
MLGRELDTHA LQRAGRTLLS DKPVAAFKNY GKKGTIAPFD LEVRPGEIVG LAGLLGSGRT
ETAEVIFGIK PADSGTALIK GKPQNLRSPH QASVLGIGFC PEDRKTDGII AAASVRENII
LALQAQRGWL RPISRKEQQE IAERFIRQLG IRTPSTEQPI EFLSGGNQQK VLLSRWLLTR
PQFLILDEPT RGIDVGAHAE IIRLIETLCA DGLALLVISS ELEELVGYAD RVIIMRDRKQ
VAEIPLAELS VPAIMNAIAA
