YTFT_ECOLI
ID YTFT_ECOLI Reviewed; 341 AA.
AC P39328; Q2M676;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Galactofuranose transporter permease protein YtfT {ECO:0000305};
GN Name=ytfT; OrderedLocusNames=b4230, JW5753;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=7610040; DOI=10.1093/nar/23.12.2105;
RA Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.;
RT "Analysis of the Escherichia coli genome VI: DNA sequence of the region
RT from 92.8 through 100 minutes.";
RL Nucleic Acids Res. 23:2105-2119(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP SUBCELLULAR LOCATION, AND TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
RN [5]
RP FUNCTION, AND SUBUNIT.
RC STRAIN=K12;
RX PubMed=19744923; DOI=10.1074/jbc.m109.054296;
RA Horler R.S., Muller A., Williamson D.C., Potts J.R., Wilson K.S.,
RA Thomas G.H.;
RT "Furanose-specific sugar transport: characterization of a bacterial
RT galactofuranose-binding protein.";
RL J. Biol. Chem. 284:31156-31163(2009).
CC -!- FUNCTION: Part of the ABC transporter complex YtfQRT-YjfF involved in
CC galactofuranose transport (Probable). Probably responsible for the
CC translocation of the substrate across the membrane (Probable).
CC {ECO:0000305, ECO:0000305|PubMed:19744923}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (YtfR),
CC two transmembrane proteins (YtfT and YjfF) and a solute-binding protein
CC (YtfQ). {ECO:0000305|PubMed:19744923}.
CC -!- INTERACTION:
CC P39328; P17952: murC; NbExp=3; IntAct=EBI-554774, EBI-554607;
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. AraH/RbsC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE78230.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; U14003; AAA97127.1; -; Genomic_DNA.
DR EMBL; U00096; AAC77187.3; -; Genomic_DNA.
DR EMBL; AP009048; BAE78230.1; ALT_INIT; Genomic_DNA.
DR PIR; S56456; S56456.
DR RefSeq; NP_418651.3; NC_000913.3.
DR AlphaFoldDB; P39328; -.
DR BioGRID; 4259314; 8.
DR BioGRID; 853034; 1.
DR ComplexPortal; CPX-4323; Galactofuranose ABC transporter complex.
DR DIP; DIP-12946N; -.
DR IntAct; P39328; 1.
DR STRING; 511145.b4230; -.
DR TCDB; 3.A.1.2.25; the atp-binding cassette (abc) superfamily.
DR PaxDb; P39328; -.
DR PRIDE; P39328; -.
DR EnsemblBacteria; AAC77187; AAC77187; b4230.
DR EnsemblBacteria; BAE78230; BAE78230; BAE78230.
DR GeneID; 948743; -.
DR KEGG; ecj:JW5753; -.
DR KEGG; eco:b4230; -.
DR PATRIC; fig|511145.12.peg.4361; -.
DR EchoBASE; EB2411; -.
DR eggNOG; COG1172; Bacteria.
DR HOGENOM; CLU_028880_3_0_6; -.
DR InParanoid; P39328; -.
DR OMA; VWNGFLV; -.
DR PhylomeDB; P39328; -.
DR BioCyc; EcoCyc:YTFT-MON; -.
DR BioCyc; MetaCyc:YTFT-MON; -.
DR PRO; PR:P39328; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0055052; C:ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing; IC:ComplexPortal.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; ISM:EcoCyc.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0140271; P:hexose import across plasma membrane; IC:ComplexPortal.
DR InterPro; IPR001851; ABC_transp_permease.
DR Pfam; PF02653; BPD_transp_2; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..341
FT /note="Galactofuranose transporter permease protein YtfT"
FT /id="PRO_0000060265"
FT TOPO_DOM 1..25
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..65
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 130..136
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..174
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 196..223
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 245..255
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 256..276
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 277..281
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 282..302
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..323
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 324..341
FT /note="Cytoplasmic"
FT /evidence="ECO:0000269|PubMed:15919996"
SQ SEQUENCE 341 AA; 35659 MW; F005F90E580E89E5 CRC64;
MMPQSLPDTT TPKRRFRWPT GMPQLVALLL VLLVDSLVAP HFWQVVLQDG RLFGSPIDIL
NRAAPVALLA IGMTLVIATG GIDLSVGAVM AIAGATTAAM TVAGFSLPIV LLSALGTGIL
AGLWNGILVA ILKIQPFVAT LILMVAGRGV AQLITAGQIV TFNSPDLSWF GSGSLLFLPT
PVIIAVLTLI LFWLLTRKTA LGMFIEAVGI NIRAAKNAGV NTRIIVMLTY VLSGLCAAIA
GIIVAADIRG ADANNAGLWL ELDAILAVVI GGGSLMGGRF NLLLSVVGAL IIQGMNTGIL
LSGFPPEMNQ VVKAVVVLCV LIVQSQRFIS LIKGVRSRDK T
