ID   YTH1_CRYNB              Reviewed;         332 AA.
AC   P0CS65; Q55X98; Q5KMN5;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=mRNA 3'-end-processing protein YTH1;
GN   Name=YTH1; OrderedLocusNames=CNBB4640;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Component of the cleavage factor I (CF I) involved in pre-
CC       mRNA 3'-end processing. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CPSF4/YTH1 family. {ECO:0000305}.
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DR   EMBL; AAEY01000010; EAL22587.1; -; Genomic_DNA.
DR   RefSeq; XP_777234.1; XM_772141.1.
DR   AlphaFoldDB; P0CS65; -.
DR   EnsemblFungi; AAW41806; AAW41806; CNB01070.
DR   EnsemblFungi; EAL22587; EAL22587; CNBB4640.
DR   GeneID; 4934558; -.
DR   KEGG; cnb:CNBB4640; -.
DR   VEuPathDB; FungiDB:CNBB4640; -.
DR   HOGENOM; CLU_024513_0_0_1; -.
DR   Proteomes; UP000001435; Chromosome 2.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0098789; P:pre-mRNA cleavage required for polyadenylation; IEA:InterPro.
DR   InterPro; IPR045348; CPSF4/Yth1.
DR   InterPro; IPR041367; Znf-CCCH_4.
DR   InterPro; IPR000571; Znf_CCCH.
DR   InterPro; IPR036855; Znf_CCCH_sf.
DR   InterPro; IPR001878; Znf_CCHC.
DR   InterPro; IPR036875; Znf_CCHC_sf.
DR   PANTHER; PTHR23102; PTHR23102; 1.
DR   Pfam; PF18044; zf-CCCH_4; 1.
DR   Pfam; PF00098; zf-CCHC; 1.
DR   SMART; SM00343; ZnF_C2HC; 1.
DR   SMART; SM00356; ZnF_C3H1; 4.
DR   SUPFAM; SSF57756; SSF57756; 1.
DR   SUPFAM; SSF90229; SSF90229; 2.
DR   PROSITE; PS50103; ZF_C3H1; 5.
DR   PROSITE; PS50158; ZF_CCHC; 1.
PE   3: Inferred from homology;
KW   Metal-binding; mRNA processing; Nucleus; Repeat; RNA-binding; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..332
FT                   /note="mRNA 3'-end-processing protein YTH1"
FT                   /id="PRO_0000410345"
FT   ZN_FING         45..74
FT                   /note="C3H1-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   ZN_FING         93..120
FT                   /note="C3H1-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   ZN_FING         121..147
FT                   /note="C3H1-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   ZN_FING         148..175
FT                   /note="C3H1-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   ZN_FING         149..174
FT                   /note="C3H1-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   ZN_FING         177..199
FT                   /note="C3H1-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   ZN_FING         301..318
FT                   /note="CCHC-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT   REGION          269..293
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        270..291
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   332 AA;  37321 MW;  F0A2BE6D8B97D67A CRC64;
     MAAASNSAPL DPKLGRAADF VRPDFHQVNL DLENYLKTER NFKLDADQQI CPLSITPLGC
     PLPPSQCPYR HTTPSQLNFK PPPPLPAHPR EREKKLTVCK HYLRNLCKMG DNCEYTHDFN
     LRTMPVCIWF VKQGKCELGG ECLYFHPRDR RVECPDYNRG FCVLGPNCPR KHIRRRLCDA
     YAAGFCPDGK DCKLAHPSPN RPPAESYINP IPPDPEAFNG PPPQLPAGYG RWREYKYDPN
     AVVVPAAAWV EGGSLSGWRA GGFLSANARR DNQRNRDNDD EGGRGSGGER KGGWQKDLST
     VLCFRCNQYG HFANNCPNQY VPGDRGGGRR RE