ID   YTH1_PANTH              Reviewed;         413 AA.
AC   P46351;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Uncharacterized 45.4 kDa protein in thiaminase I 5'region;
OS   Paenibacillus thiaminolyticus (Bacillus thiaminolyticus).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX   NCBI_TaxID=49283;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8631946; DOI=10.1074/jbc.271.7.3445;
RA   Costello C.A., Kelleher N.L., Abe M., McLafferty F.W., Begley T.P.;
RT   "Mechanistic studies on thiaminase I. Overexpression and identification of
RT   the active site nucleophile.";
RL   J. Biol. Chem. 271:3445-3452(1996).
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DR   EMBL; U17168; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; P46351; -.
DR   SMR; P46351; -.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1000; -; 2.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR006357; HAD-SF_hydro_IIA.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR020476; Nudix_hydrolase.
DR   InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR   InterPro; IPR020084; NUDIX_hydrolase_CS.
DR   InterPro; IPR000086; NUDIX_hydrolase_dom.
DR   Pfam; PF13344; Hydrolase_6; 1.
DR   Pfam; PF00293; NUDIX; 1.
DR   PRINTS; PR00502; NUDIXFAMILY.
DR   SUPFAM; SSF55811; SSF55811; 1.
DR   SUPFAM; SSF56784; SSF56784; 1.
DR   TIGRFAMs; TIGR01460; HAD-SF-IIA; 1.
DR   PROSITE; PS51462; NUDIX; 1.
DR   PROSITE; PS00893; NUDIX_BOX; 1.
PE   4: Predicted;
KW   Hydrolase.
FT   CHAIN           1..413
FT                   /note="Uncharacterized 45.4 kDa protein in thiaminase I
FT                   5'region"
FT                   /id="PRO_0000057156"
FT   DOMAIN          273..406
FT                   /note="Nudix hydrolase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00794"
FT   MOTIF           305..326
FT                   /note="Nudix box"
SQ   SEQUENCE   413 AA;  45449 MW;  F7E7971444BD8D56 CRC64;
     MLFDAFDVFL FDLDGVIYVG PEALPGAVEA LERLRSGGKT IRFLTNNPCM TREQTAARLN
     RLGIEAAKDE VISSGWATAC CLRERRAGSV YVLGDEHLER ECRDAGLDIV DVNAAEAVVV
     GWSDDLTLRD IQSAVTRIAN GAQFIATNAD WSFPGPDGPM MAVGTAVEAI KMASGKTPYI
     VGKPYPYMFR QALQHVEDWS RAVMFGDTPD ADIAGAHRIG ISAVLISSGP YTGYSSARDY
     RKPDAIIPDL RSLWDEELRI ERWIPPAFPW PDDIKPGVAG IVMDERGRVL LMKRADNGCW
     GLPSGHVERG ESVEEAIVRE IREETGLQVE VMRLVGLYSD PESQVFTYPD GAATQFVTAC
     FRCETVGGAL VRTGAETLDV NYFEAERLPD PILAMHPRWI ADALAEESLC IFR