YTLI_BACSU
ID YTLI_BACSU Reviewed; 308 AA.
AC O35038;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=HTH-type transcriptional regulator YtlI;
GN Name=ytlI; OrderedLocusNames=BSU29400;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9387221; DOI=10.1099/00221287-143-11-3431;
RA Lapidus A., Galleron N., Sorokin A., Ehrlich S.D.;
RT "Sequencing and functional annotation of the Bacillus subtilis genes in the
RT 200 kb rrnB-dnaB region.";
RL Microbiology 143:3431-3441(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP FUNCTION.
RX PubMed=11390694; DOI=10.1099/00221287-147-6-1631;
RA Coppee J.Y., Auger S., Turlin E., Sekowska A., Le Caer J.-P., Labas V.,
RA Vagner V., Danchin A., Martin-Verstraete I.;
RT "Sulfur-limitation-regulated proteins in Bacillus subtilis: a two-
RT dimensional gel electrophoresis study.";
RL Microbiology 147:1631-1640(2001).
RN [4]
RP FUNCTION.
RX PubMed=16109943; DOI=10.1128/jb.187.17.6019-6030.2005;
RA Burguiere P., Fert J., Guillouard I., Auger S., Danchin A.,
RA Martin-Verstraete I.;
RT "Regulation of the Bacillus subtilis ytmI operon, involved in sulfur
RT metabolism.";
RL J. Bacteriol. 187:6019-6030(2005).
CC -!- FUNCTION: Positively regulates the expression of ytmI operon in
CC response to the availability of sulfur sources.
CC {ECO:0000269|PubMed:11390694, ECO:0000269|PubMed:16109943}.
CC -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC {ECO:0000305}.
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DR EMBL; AF008220; AAC00402.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB14900.1; -; Genomic_DNA.
DR PIR; E69995; E69995.
DR RefSeq; NP_390818.1; NC_000964.3.
DR RefSeq; WP_004398915.1; NZ_JNCM01000036.1.
DR AlphaFoldDB; O35038; -.
DR SMR; O35038; -.
DR STRING; 224308.BSU29400; -.
DR PaxDb; O35038; -.
DR PRIDE; O35038; -.
DR EnsemblBacteria; CAB14900; CAB14900; BSU_29400.
DR GeneID; 938452; -.
DR KEGG; bsu:BSU29400; -.
DR PATRIC; fig|224308.179.peg.3194; -.
DR eggNOG; COG0583; Bacteria.
DR InParanoid; O35038; -.
DR OMA; PWIFGGS; -.
DR PhylomeDB; O35038; -.
DR BioCyc; BSUB:BSU29400-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR005119; LysR_subst-bd.
DR InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00126; HTH_1; 1.
DR Pfam; PF03466; LysR_substrate; 1.
DR PRINTS; PR00039; HTHLYSR.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50931; HTH_LYSR; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..308
FT /note="HTH-type transcriptional regulator YtlI"
FT /id="PRO_0000105820"
FT DOMAIN 1..57
FT /note="HTH lysR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT DNA_BIND 18..37
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ SEQUENCE 308 AA; 35233 MW; CF3773D9CAE34F56 CRC64;
MELRSIKTFH TIVKFGSFYK AAEILNYSQP TISMRMKQLE QDLGVLLFER GKSLQLTKAG
KLFYERTGDL LMQYEALKHN LSDLKEEEAG IINIGVSEPT ASLIFPEILK DFLMDYPKIT
VNIKVDDANT CSQKLLDGTI DFAVCGEPEL ILENYYHPFF YDTLNVIVSD QHPLAEKKAV
HLSDLAEERF IFTPANCPIR LQIEQHLHRE LGNRYKKMEL TSSMSHEYYV RENIGISIFT
STAHSKPFNG TKVIPILNLD ITPPIGLLTN QKEVHFDRAT KDLIARITKR FQQRSKELEG
TSDKTITG
