ID   YTM1_AJECN              Reviewed;         490 AA.
AC   A6R3K5;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Ribosome biogenesis protein YTM1 {ECO:0000255|HAMAP-Rule:MF_03029};
GN   Name=YTM1 {ECO:0000255|HAMAP-Rule:MF_03029}; ORFNames=HCAG_04213;
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma;
OC   unclassified Histoplasma.
OX   NCBI_TaxID=2059318;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- FUNCTION: Component of the NOP7 complex, which is required for
CC       maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC       ribosome. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC       YTM1. The complex is held together by ERB1, which interacts with NOP7
CC       via its N-terminal domain and with YTM1 via a high-affinity interaction
CC       between the seven-bladed beta-propeller domains of the 2 proteins. The
CC       NOP7 complex associates with the 66S pre-ribosome. Interacts (via UBL
CC       domain) with MDN1 (via VWFA/MIDAS domain). {ECO:0000255|HAMAP-
CC       Rule:MF_03029}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03029}.
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DR   EMBL; CH476658; EDN07703.1; -; Genomic_DNA.
DR   RefSeq; XP_001540373.1; XM_001540323.1.
DR   AlphaFoldDB; A6R3K5; -.
DR   SMR; A6R3K5; -.
DR   STRING; 339724.A6R3K5; -.
DR   EnsemblFungi; EDN07703; EDN07703; HCAG_04213.
DR   GeneID; 5446789; -.
DR   KEGG; aje:HCAG_04213; -.
DR   VEuPathDB; FungiDB:HCAG_04213; -.
DR   HOGENOM; CLU_000288_57_0_1; -.
DR   OMA; VDCTRTK; -.
DR   OrthoDB; 1540178at2759; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03029; WDR12; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR012972; NLE.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR028599; WDR12/Ytm1.
DR   Pfam; PF08154; NLE; 1.
DR   Pfam; PF00400; WD40; 3.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..490
FT                   /note="Ribosome biogenesis protein YTM1"
FT                   /id="PRO_0000369572"
FT   REPEAT          116..168
FT                   /note="WD 1"
FT   REPEAT          175..213
FT                   /note="WD 2"
FT   REPEAT          224..263
FT                   /note="WD 3"
FT   REPEAT          298..338
FT                   /note="WD 4"
FT   REPEAT          340..379
FT                   /note="WD 5"
FT   REPEAT          385..425
FT                   /note="WD 6"
FT   REPEAT          449..487
FT                   /note="WD 7"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          23..104
FT                   /note="Ubiquitin-like (UBL) domain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
FT   REGION          255..286
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   490 AA;  52709 MW;  F48CBF52CB8EBE25 CRC64;
     MDGLEDGPLD ASTATSQKPQ RQVRLKLTSR HEDIALPEST GPILVPTGLR RYALSTLVNN
     LLESEKPIPF EFLINGTYLR TSIDEYLTAN GISAETTLDV EYVRALVPPL HVASFLHDDW
     VSAVDVLSDT SIAGSKSRVN AGQERILSAS YDGLLRMWNM SSETIALSPA AREGGHTASV
     KCARMVSPSQ IISSGLDRTV RLWKYTESED GFSASITPQL ELYGHKGSVD SISMHAQSHR
     ILSASADHSV GFWSTRKSEN PAAPESLLPS NTSRSSKRRK LNSSVSVPQR GPLALFKSHT
     APVSAAIFDA KDPTVGYSTS WDHSLRTWDL VTGTLVDTRT ASHSLLSVSH MPELSLLASG
     TSARHITLID PRASATTVSA LTLRGHTNAV VCLARDPDST YGLISGSHDG TCRIWDVRST
     RTDKDGVMGE SIYSIPRKSV GGAGKRVGGE GVKVFDVCWD KSVGIVSSGE DKMIQINRGE
     GVLPNGGSDR