YTM1_ASPCL
ID YTM1_ASPCL Reviewed; 488 AA.
AC A1CH75;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Ribosome biogenesis protein ytm1 {ECO:0000255|HAMAP-Rule:MF_03029};
GN Name=ytm1; ORFNames=ACLA_046950;
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of erb1, nop7 and
CC ytm1. The complex is held together by erb1, which interacts with nop7
CC via its N-terminal domain and with ytm1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. Interacts (via UBL
CC domain) with mdn1 (via VWFA/MIDAS domain). {ECO:0000255|HAMAP-
CC Rule:MF_03029}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03029}.
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DR EMBL; DS027054; EAW10230.1; -; Genomic_DNA.
DR RefSeq; XP_001271656.1; XM_001271655.1.
DR AlphaFoldDB; A1CH75; -.
DR SMR; A1CH75; -.
DR STRING; 5057.CADACLAP00004707; -.
DR EnsemblFungi; EAW10230; EAW10230; ACLA_046950.
DR GeneID; 4704389; -.
DR KEGG; act:ACLA_046950; -.
DR VEuPathDB; FungiDB:ACLA_046950; -.
DR eggNOG; KOG0313; Eukaryota.
DR HOGENOM; CLU_000288_57_0_1; -.
DR OMA; VDCTRTK; -.
DR OrthoDB; 1540178at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0070545; C:PeBoW complex; IEA:EnsemblFungi.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051276; P:chromosome organization; IEA:EnsemblFungi.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0110136; P:protein-RNA complex remodeling; IEA:EnsemblFungi.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03029; WDR12; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR012972; NLE.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR028599; WDR12/Ytm1.
DR Pfam; PF08154; NLE; 1.
DR Pfam; PF00400; WD40; 3.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..488
FT /note="Ribosome biogenesis protein ytm1"
FT /id="PRO_0000369574"
FT REPEAT 128..167
FT /note="WD 1"
FT REPEAT 174..212
FT /note="WD 2"
FT REPEAT 223..262
FT /note="WD 3"
FT REPEAT 297..337
FT /note="WD 4"
FT REPEAT 339..378
FT /note="WD 5"
FT REPEAT 384..424
FT /note="WD 6"
FT REPEAT 452..488
FT /note="WD 7"
FT REGION 20..101
FT /note="Ubiquitin-like (UBL) domain"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
SQ SEQUENCE 488 AA; 51977 MW; 457C293B8D6D46FF CRC64;
MEDIQNSASN ADLSAAQRQV RVQLTSKQED IALPDGTGPI LVPTGLRRYA LSTLVNNLLS
NDKPIPFEFL INGTFLRTSI DEYLTANGIS AETTLEIEYV RALIPPLHIA SFQHDDWVSS
TDVLSATSPA ATWASAAISP GQERILSGSY DGLLRVWNMS SQVVATSPPA ADGGHAASIK
AAKFVTPNQI VSAGLDRTVR LWKYSESEDG FSGTIAPHLE LYGHKSGINS LAVHAPSHRL
LSASSDHSVG FWSTKKSDAP AAPENLLPSA AARSSKRRKL NSSVSVAQRG PVALLSSHTA
PVSAAIFDAK DSTVGYSTSW DHSLRTWDLV TATLVDTRTA SHSLLSLEHL PELSLLAAGT
SARHITLIDP RASATTISAM TLRGHTNAVV SLARDPHSTY GLISGSHDGT CRIWDIRATK
ADKDGVVGES VYTISRKGLE EQGKADSKRV GGEGVKVFSV CWDKTIGIVS AGEDKRIQIN
RGEGMLSA
