YTM1_ASPFC
ID YTM1_ASPFC Reviewed; 488 AA.
AC B0Y5V6;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 25-MAY-2022, entry version 67.
DE RecName: Full=Ribosome biogenesis protein ytm1 {ECO:0000255|HAMAP-Rule:MF_03029};
GN Name=ytm1; ORFNames=AFUB_064720;
OS Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus
OS fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=451804;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CEA10 / CBS 144.89 / FGSC A1163;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of erb1, nop7 and
CC ytm1. The complex is held together by erb1, which interacts with nop7
CC via its N-terminal domain and with ytm1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. Interacts (via UBL
CC domain) with mdn1 (via VWFA/MIDAS domain). {ECO:0000255|HAMAP-
CC Rule:MF_03029}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03029}.
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DR EMBL; DS499598; EDP50141.1; -; Genomic_DNA.
DR AlphaFoldDB; B0Y5V6; -.
DR SMR; B0Y5V6; -.
DR EnsemblFungi; EDP50141; EDP50141; AFUB_064720.
DR VEuPathDB; FungiDB:AFUB_064720; -.
DR HOGENOM; CLU_000288_57_0_1; -.
DR PhylomeDB; B0Y5V6; -.
DR Proteomes; UP000001699; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0070545; C:PeBoW complex; IEA:EnsemblFungi.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051276; P:chromosome organization; IEA:EnsemblFungi.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0110136; P:protein-RNA complex remodeling; IEA:EnsemblFungi.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03029; WDR12; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR012972; NLE.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR028599; WDR12/Ytm1.
DR Pfam; PF08154; NLE; 1.
DR Pfam; PF00400; WD40; 3.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus; Repeat; Ribosome biogenesis; rRNA processing; WD repeat.
FT CHAIN 1..488
FT /note="Ribosome biogenesis protein ytm1"
FT /id="PRO_0000369575"
FT REPEAT 128..167
FT /note="WD 1"
FT REPEAT 174..212
FT /note="WD 2"
FT REPEAT 223..262
FT /note="WD 3"
FT REPEAT 297..337
FT /note="WD 4"
FT REPEAT 339..378
FT /note="WD 5"
FT REPEAT 384..424
FT /note="WD 6"
FT REPEAT 452..488
FT /note="WD 7"
FT REGION 20..101
FT /note="Ubiquitin-like (UBL) domain"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
FT REGION 257..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 488 AA; 51997 MW; 90DA27E04A1F67DA CRC64;
MNDGSNSDAT ATSSAAQRQV RVQLTSKQED IALPDNTGPI LVPTSLRRYA LSTLVNKLLG
NDKPIPFEFL INGTFLRTSI DEYLTANGIS AETTLEIEYV RALIPPLHIA SFQHDDWVSS
TDVLSATSPA ATWASATISQ GQEKILSGSY DGLLRVWNMS SQIVATSPAA ADGGHTASIK
AAKFVTPNQI ASAGLDRTVR LWKYAESDEG FSGTIAPQLE LYGHKSGINS LAVHALSNRI
LSASSDNSVG FWSTKKSDAP AAPDDLLPSA ASRSSKRRKL NSSVTVPQRG PLALLSSHTA
PVSAAIFDAK DSTVGYSASW DHSMRTWDLV TSALVDTRTT SHSLLSLEHL PELNLLAAGT
SARHITLIDP RASATTISAM TLRGHTNAVV SLARDPHSTY GLISGSHDGT CRIWDIRATK
TDKDGAVGES VYSISRKSLE EQGRSDTKRV GGEGVKVFSV CWDKTVGIVS AGEDKRIQIN
RGEGVLSA
