YTM1_ASPTN
ID YTM1_ASPTN Reviewed; 483 AA.
AC Q0CLJ4;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 14-APR-2009, sequence version 2.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=Ribosome biogenesis protein ytm1 {ECO:0000255|HAMAP-Rule:MF_03029};
GN Name=ytm1; ORFNames=ATEG_05440;
OS Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=341663;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIH 2624 / FGSC A1156;
RA Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA Nierman W.C., Milne T., Madden K.;
RT "Annotation of the Aspergillus terreus NIH2624 genome.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of erb1, nop7 and
CC ytm1. The complex is held together by erb1, which interacts with nop7
CC via its N-terminal domain and with ytm1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. Interacts (via UBL
CC domain) with mdn1 (via VWFA/MIDAS domain). {ECO:0000255|HAMAP-
CC Rule:MF_03029}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03029}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAU34509.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; CH476600; EAU34509.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_001214618.1; XM_001214618.1.
DR AlphaFoldDB; Q0CLJ4; -.
DR SMR; Q0CLJ4; -.
DR STRING; 341663.Q0CLJ4; -.
DR EnsemblFungi; EAU34509; EAU34509; ATEG_05440.
DR GeneID; 4321168; -.
DR eggNOG; KOG0313; Eukaryota.
DR OrthoDB; 1540178at2759; -.
DR Proteomes; UP000007963; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0070545; C:PeBoW complex; IEA:EnsemblFungi.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051276; P:chromosome organization; IEA:EnsemblFungi.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0110136; P:protein-RNA complex remodeling; IEA:EnsemblFungi.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03029; WDR12; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR012972; NLE.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR028599; WDR12/Ytm1.
DR Pfam; PF08154; NLE; 1.
DR Pfam; PF00400; WD40; 4.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..483
FT /note="Ribosome biogenesis protein ytm1"
FT /id="PRO_0000369579"
FT REPEAT 117..161
FT /note="WD 1"
FT REPEAT 168..206
FT /note="WD 2"
FT REPEAT 217..256
FT /note="WD 3"
FT REPEAT 291..331
FT /note="WD 4"
FT REPEAT 333..372
FT /note="WD 5"
FT REPEAT 378..418
FT /note="WD 6"
FT REPEAT 446..483
FT /note="WD 7"
FT REGION 14..95
FT /note="Ubiquitin-like (UBL) domain"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
FT REGION 251..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 483 AA; 51444 MW; 9345A7D1D188C5DB CRC64;
MSASAASQAA QRQVRVQLTS KQEDIALPED TGPILIPTGL RRYALSTLVN NLLGNEKPIP
FEFLINGAFL RTSIDEYLTA NGISAETTLE IEYVRALIPP LHIASFEHDD WVSSVDVLSA
TSPAASWASA SVPQGQERIL SGSYDGFLRV WNMSSQVVAT SPAATEGGHT ASIKAAKFVS
PNSIVSAGLD RTVRLWKYSE SDDGFSGTIA PQLELYGHKL DINSLAVHAP SNRILSASSD
HMVGFWSTKK SDAPAAPENL LPSAASRSSK RRKLNSSVST PQRGPLALMS GHTAPVSAAI
FDANDSTVGY STSWDHSLRT WDLVTSSLVD TRTTSHSLLA LAHLPDHHLL AAGTSARHIT
LIDPRVSAAT IAAMTLRGHT NAVVSLARDP HSNYGLISGS HDGTCRIWDI RATKTDKDGV
VGESVYSITR KSLEEEGKSA SKRVGGEGVK VFGVCWDAAV GIVSAGEDKR IQINRGEGVL
SST
