YTM1_CANAL
ID YTM1_CANAL Reviewed; 466 AA.
AC Q5APF0; A0A1D8PEL4;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Ribosome biogenesis protein YTM1 {ECO:0000255|HAMAP-Rule:MF_03029};
GN Name=YTM1 {ECO:0000255|HAMAP-Rule:MF_03029};
GN OrderedLocusNames=CAALFM_C109510WA; ORFNames=CaO19.12278, CaO19.4815;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC YTM1. The complex is held together by ERB1, which interacts with NOP7
CC via its N-terminal domain and with YTM1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. Interacts (via UBL
CC domain) with MDN1 (via VWFA/MIDAS domain). {ECO:0000255|HAMAP-
CC Rule:MF_03029}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03029}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP017623; AOW26584.1; -; Genomic_DNA.
DR RefSeq; XP_723501.1; XM_718408.2.
DR AlphaFoldDB; Q5APF0; -.
DR SMR; Q5APF0; -.
DR BioGRID; 1217859; 1.
DR STRING; 237561.Q5APF0; -.
DR GeneID; 3634765; -.
DR KEGG; cal:CAALFM_C109510WA; -.
DR CGD; CAL0000176486; YTM1.
DR VEuPathDB; FungiDB:C1_09510W_A; -.
DR eggNOG; KOG0313; Eukaryota.
DR HOGENOM; CLU_000288_57_0_1; -.
DR InParanoid; Q5APF0; -.
DR OrthoDB; 1540178at2759; -.
DR PRO; PR:Q5APF0; -.
DR Proteomes; UP000000559; Chromosome 1.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0070545; C:PeBoW complex; IBA:GO_Central.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009267; P:cellular response to starvation; IMP:CGD.
DR GO; GO:0030447; P:filamentous growth; IMP:CGD.
DR GO; GO:0036180; P:filamentous growth of a population of unicellular organisms in response to biotic stimulus; IMP:CGD.
DR GO; GO:0036170; P:filamentous growth of a population of unicellular organisms in response to starvation; IMP:CGD.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03029; WDR12; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR012972; NLE.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR028599; WDR12/Ytm1.
DR Pfam; PF08154; NLE; 1.
DR Pfam; PF00400; WD40; 3.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..466
FT /note="Ribosome biogenesis protein YTM1"
FT /id="PRO_0000369581"
FT REPEAT 124..163
FT /note="WD 1"
FT REPEAT 165..203
FT /note="WD 2"
FT REPEAT 219..258
FT /note="WD 3"
FT REPEAT 296..336
FT /note="WD 4"
FT REPEAT 338..377
FT /note="WD 5"
FT REPEAT 384..424
FT /note="WD 6"
FT REPEAT 431..466
FT /note="WD 7"
FT REGION 11..99
FT /note="Ubiquitin-like (UBL) domain"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
FT REGION 109..466
FT /note="Sufficient for interaction with ERB1 and association
FT with 66S pre-ribosomes"
FT /evidence="ECO:0000250"
SQ SEQUENCE 466 AA; 51690 MW; F5BD64E80A0833C9 CRC64;
MSSTGENKNQ IKIKFFTNEE DESLQVADTP LYVPVTLKRF GLSEVVNHLL GNFKGEDETK
APIPFDFLID GVLLRTSIED YLTKNGLSNE AFLTLEYTRA ILPPSFLASF NNDDWISSID
SINPTTKIVM SSQLSISQPK ILSGSYDGIV RTYNMSGKVE KQYVGHSAPV KAVKWISPTR
IVSAGNDRQV RLWKTSYEEI IDEDEEEIED GKTLALLEGH KAPVVDLAVD TQTNRILSAG
YDQNIGFWST NYKEMTSIQP LEYDSNVVSS SSKKRRKMAV QDATIRRRAP LSLLQGHSEP
VEGVIFDAKD STVGYSVSQD HTIKTWDLVT SRCVDTRTTG YSLLSVLQLP QVNLIASGSS
ARHINLHDPR VTTTSDQTIS KLVGHTNFVV GLTASPHNQN MFASSSHDGT VKVWDVRAEK
SLYTITRQDG STNAKIFDVC WDDRIGIISG GEDKKLQINK GSDIAK
