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YTM1_CHAGB
ID   YTM1_CHAGB              Reviewed;         484 AA.
AC   Q2GXT0;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Ribosome biogenesis protein YTM1 {ECO:0000255|HAMAP-Rule:MF_03029};
GN   Name=YTM1 {ECO:0000255|HAMAP-Rule:MF_03029}; ORFNames=CHGG_07224;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: Component of the NOP7 complex, which is required for
CC       maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC       ribosome. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC       YTM1. The complex is held together by ERB1, which interacts with NOP7
CC       via its N-terminal domain and with YTM1 via a high-affinity interaction
CC       between the seven-bladed beta-propeller domains of the 2 proteins. The
CC       NOP7 complex associates with the 66S pre-ribosome. Interacts (via UBL
CC       domain) with MDN1 (via VWFA/MIDAS domain). {ECO:0000255|HAMAP-
CC       Rule:MF_03029}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03029}.
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DR   EMBL; CH408033; EAQ85971.1; -; Genomic_DNA.
DR   RefSeq; XP_001224880.1; XM_001224879.1.
DR   AlphaFoldDB; Q2GXT0; -.
DR   SMR; Q2GXT0; -.
DR   STRING; 38033.XP_001224880.1; -.
DR   PRIDE; Q2GXT0; -.
DR   EnsemblFungi; EAQ85971; EAQ85971; CHGG_07224.
DR   GeneID; 4393224; -.
DR   eggNOG; KOG0313; Eukaryota.
DR   HOGENOM; CLU_000288_57_0_1; -.
DR   InParanoid; Q2GXT0; -.
DR   OMA; VDCTRTK; -.
DR   OrthoDB; 1540178at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03029; WDR12; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR012972; NLE.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR028599; WDR12/Ytm1.
DR   Pfam; PF08154; NLE; 1.
DR   Pfam; PF00400; WD40; 3.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..484
FT                   /note="Ribosome biogenesis protein YTM1"
FT                   /id="PRO_0000369583"
FT   REPEAT          122..161
FT                   /note="WD 1"
FT   REPEAT          168..206
FT                   /note="WD 2"
FT   REPEAT          216..255
FT                   /note="WD 3"
FT   REPEAT          288..328
FT                   /note="WD 4"
FT   REPEAT          330..373
FT                   /note="WD 5"
FT   REPEAT          379..419
FT                   /note="WD 6"
FT   REPEAT          448..484
FT                   /note="WD 7"
FT   REGION          13..95
FT                   /note="Ubiquitin-like (UBL) domain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
SQ   SEQUENCE   484 AA;  51426 MW;  A24600AD31B7BC0E CRC64;
     MDEPMVDASG AQVKVTFTTT EADLQLPESK RQLLVPADIR RYGLSRVLNS ESMLDTGSIP
     FDFLVNGSFL RTSLEDYLTN NGLSLESNLT LQYVRSLIPP VYEASFEHDD WVSAVDVLSA
     SSPSGRWSGD NFQRGQDRIL SASFDGLLRI WNASGQVIAT SPSGSHGGHT ASIKAAKFLT
     NSQLASAGMD RTVRVWKYTE SDHFSGDLKP TLELYGHTGS IDSLEVDGAS KRILTASADG
     SIGFWSTSKA SAPEADSSLL PNAHTSKRRK VTTSVTAAQR GPLSLMPIHS APASAAVFDP
     RDRTVAYSAS QDHTLRTIDL TTSTVVTTHS TSHPLLSLCA LPRGNSASPL LAAGTAARHI
     TLVDPRASAA TTSVMTLRGH ANKPVGLCAS PRNEYALVSG AHDGTCRVWD LRSVRPATQE
     EGGLGSVSEA VYVIEREGAK GGKKTVAGEG CKVFGVVWDA ELGIVSGAED KRVQINAGRD
     VVAE
 
 
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