ID   YTM1_CRYNB              Reviewed;         486 AA.
AC   P0CS55; Q55HS5; Q5K7B0;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Ribosome biogenesis protein YTM1 {ECO:0000255|HAMAP-Rule:MF_03029};
GN   Name=YTM1 {ECO:0000255|HAMAP-Rule:MF_03029}; OrderedLocusNames=CNBN0460;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Component of the NOP7 complex, which is required for
CC       maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC       ribosome. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC       YTM1. The complex is held together by ERB1, which interacts with NOP7
CC       via its N-terminal domain and with YTM1 via a high-affinity interaction
CC       between the seven-bladed beta-propeller domains of the 2 proteins. The
CC       NOP7 complex associates with the 66S pre-ribosome. Interacts (via UBL
CC       domain) with MDN1 (via VWFA/MIDAS domain). {ECO:0000255|HAMAP-
CC       Rule:MF_03029}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03029}.
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DR   EMBL; AAEY01000066; EAL17218.1; -; Genomic_DNA.
DR   RefSeq; XP_771865.1; XM_766772.1.
DR   AlphaFoldDB; P0CS55; -.
DR   SMR; P0CS55; -.
DR   EnsemblFungi; AAW47063; AAW47063; CNN00480.
DR   EnsemblFungi; EAL17218; EAL17218; CNBN0460.
DR   GeneID; 4939654; -.
DR   KEGG; cnb:CNBN0460; -.
DR   VEuPathDB; FungiDB:CNBN0460; -.
DR   HOGENOM; CLU_000288_57_0_1; -.
DR   Proteomes; UP000001435; Chromosome 14.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03029; WDR12; 1.
DR   InterPro; IPR012972; NLE.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR028599; WDR12/Ytm1.
DR   Pfam; PF08154; NLE; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Nucleus; Repeat; Ribosome biogenesis; rRNA processing; WD repeat.
FT   CHAIN           1..486
FT                   /note="Ribosome biogenesis protein YTM1"
FT                   /id="PRO_0000410340"
FT   REPEAT          212..251
FT                   /note="WD 1"
FT   REPEAT          305..345
FT                   /note="WD 2"
FT   REPEAT          349..388
FT                   /note="WD 3"
FT   REPEAT          392..432
FT                   /note="WD 4"
FT   REPEAT          454..486
FT                   /note="WD 5"
FT   REGION          12..99
FT                   /note="Ubiquitin-like (UBL) domain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
FT   REGION          249..299
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        266..282
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   486 AA;  52332 MW;  68FDB1EACC5DF9A8 CRC64;
     MSIDPAGSQA SRQLPINLFT RSPTDAIPQS TYFIPSAWRR FQLSELINQV LGNTAENGSK
     PVPFDFLVNG EVLRGSLEAW VKKNRGGDEE SQIDVEYVRS VMPPEEAARV EVEDWVSGLS
     LSRKGYVLLS SYLSHLQVLP LSAAAQSSSA LYTLPLPTSL GATSCTWVSP QTQETDILVA
     AGGVDRQTHV YSIPSLSPDT ADAPRELYTL HGHTGPISSV IASSSGKEIV TGSWDGNINL
     YVLPDAEPTE HQVPADPVSY LPGQGTKKRR KLEKDQEKAP IEGLTDGDAT GEGGWRRAPD
     AVMRGHTGRV GGLVWDKLDS GKIWSAGWDG SVRGWEVETG AAGALRQGPF DKSALCVDQW
     KMNGTLATGN MDRTICLWDT RQATSLISLT LPTTSPVPSV TCHPTSPFTL ASATYSGVVQ
     IWDIRSPKTA LFTVSKAQSK LADPNRKVTK NGKVLGERLL AVDWNGEVLV AGGEDGEVGI
     WRARGE