YTM1_DEBHA
ID YTM1_DEBHA Reviewed; 466 AA.
AC Q6BLS5;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 2.
DT 25-MAY-2022, entry version 115.
DE RecName: Full=Ribosome biogenesis protein YTM1 {ECO:0000255|HAMAP-Rule:MF_03029};
GN Name=YTM1 {ECO:0000255|HAMAP-Rule:MF_03029};
GN OrderedLocusNames=DEHA2F11066g;
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC YTM1. The complex is held together by ERB1, which interacts with NOP7
CC via its N-terminal domain and with YTM1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. Interacts (via UBL
CC domain) with MDN1 (via VWFA/MIDAS domain). {ECO:0000255|HAMAP-
CC Rule:MF_03029}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03029}.
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DR EMBL; CR382138; CAG89191.2; -; Genomic_DNA.
DR RefSeq; XP_460846.2; XM_460846.1.
DR AlphaFoldDB; Q6BLS5; -.
DR SMR; Q6BLS5; -.
DR STRING; 4959.XP_460846.2; -.
DR EnsemblFungi; CAG89191; CAG89191; DEHA2F11066g.
DR GeneID; 2903586; -.
DR KEGG; dha:DEHA2F11066g; -.
DR VEuPathDB; FungiDB:DEHA2F11066g; -.
DR eggNOG; KOG0313; Eukaryota.
DR HOGENOM; CLU_000288_57_0_1; -.
DR InParanoid; Q6BLS5; -.
DR OMA; VDCTRTK; -.
DR OrthoDB; 1540178at2759; -.
DR Proteomes; UP000000599; Chromosome F.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03029; WDR12; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR012972; NLE.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR028599; WDR12/Ytm1.
DR Pfam; PF08154; NLE; 1.
DR Pfam; PF00400; WD40; 4.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..466
FT /note="Ribosome biogenesis protein YTM1"
FT /id="PRO_0000369587"
FT REPEAT 120..159
FT /note="WD 1"
FT REPEAT 161..199
FT /note="WD 2"
FT REPEAT 214..253
FT /note="WD 3"
FT REPEAT 291..331
FT /note="WD 4"
FT REPEAT 333..372
FT /note="WD 5"
FT REPEAT 381..421
FT /note="WD 6"
FT REPEAT 431..466
FT /note="WD 7"
FT REGION 8..95
FT /note="Ubiquitin-like (UBL) domain"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
FT REGION 105..466
FT /note="Sufficient for interaction with ERB1 and association
FT with 66S pre-ribosomes"
FT /evidence="ECO:0000250"
SQ SEQUENCE 466 AA; 51970 MW; 3968EC3D8025B6CD CRC64;
MADDKSQIKI NFFTNEEDES LHTSDAPLYV PVSLKRYGLS EIVNHLLKKD GETDETKPVP
FDFLIDGVLL RTSLEDYLVK NGLSSEASLN LEYTRAVLPP SFLASFNNDD WISSLDTINP
LSASVKASNM SISQPKILSG SYDGIVRTYN MSGKVEKQYV GHSGPIRSVK WISPTRIVSS
GNDRQVRLWK TSIDSNIEDD EEIEDGRTLA ILEGHKAPVV SLAVEYQNNR ILSAGYDKAI
GFWSTNYREM TTIQPLEYDS NVISTSSKKR RKMALQDSTI RRRSPLSFLE GHSQPVEDVI
FDFNDATVGY SVSQDHTIKT WDLVTSRCVD TRTTGYSLLS LLQLPSLNLL VCGSSARHIN
LFDPRVSSTT TEQTNNQKLI GHTNFVVGLS KCPTNDNMFA SCSHDGTVKV WDVRSEKSLY
TITREQNNAA KGQDKVFSVI WDNDIGIISG GQDKKIQINK GSDITK
