YTM1_LODEL
ID YTM1_LODEL Reviewed; 491 AA.
AC A5DST9;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Ribosome biogenesis protein YTM1 {ECO:0000255|HAMAP-Rule:MF_03029};
GN Name=YTM1 {ECO:0000255|HAMAP-Rule:MF_03029}; ORFNames=LELG_00425;
OS Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC Lodderomyces.
OX NCBI_TaxID=379508;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL
RC YB-4239;
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA Birren B.W., Kellis M., Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC YTM1. The complex is held together by ERB1, which interacts with NOP7
CC via its N-terminal domain and with YTM1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. Interacts (via UBL
CC domain) with MDN1 (via VWFA/MIDAS domain). {ECO:0000255|HAMAP-
CC Rule:MF_03029}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03029}.
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DR EMBL; CH981524; EDK42247.1; -; Genomic_DNA.
DR RefSeq; XP_001527905.1; XM_001527855.1.
DR AlphaFoldDB; A5DST9; -.
DR SMR; A5DST9; -.
DR STRING; 379508.A5DST9; -.
DR EnsemblFungi; EDK42247; EDK42247; LELG_00425.
DR GeneID; 5235041; -.
DR KEGG; lel:LELG_00425; -.
DR VEuPathDB; FungiDB:LELG_00425; -.
DR eggNOG; KOG0313; Eukaryota.
DR HOGENOM; CLU_000288_57_0_1; -.
DR InParanoid; A5DST9; -.
DR OMA; VDCTRTK; -.
DR OrthoDB; 1540178at2759; -.
DR Proteomes; UP000001996; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03029; WDR12; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR012972; NLE.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR028599; WDR12/Ytm1.
DR Pfam; PF08154; NLE; 1.
DR Pfam; PF00400; WD40; 2.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..491
FT /note="Ribosome biogenesis protein YTM1"
FT /id="PRO_0000369591"
FT REPEAT 128..167
FT /note="WD 1"
FT REPEAT 169..207
FT /note="WD 2"
FT REPEAT 241..280
FT /note="WD 3"
FT REPEAT 318..358
FT /note="WD 4"
FT REPEAT 360..399
FT /note="WD 5"
FT REPEAT 409..449
FT /note="WD 6"
FT REPEAT 456..491
FT /note="WD 7"
FT REGION 8..103
FT /note="Ubiquitin-like (UBL) domain"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
FT REGION 113..491
FT /note="Sufficient for interaction with ERB1 and association
FT with 66S pre-ribosomes"
FT /evidence="ECO:0000250"
FT REGION 205..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..226
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 491 AA; 54439 MW; 30D4B701144ABFD6 CRC64;
MSDDKNQIKI KFTTNESDES LKVEETPLYV PVTLKRYGLS EIVNHLLETQ KALESESGED
DEERKPVPFN FLINGELLRT SISDYLTRNG LSSEAFLTIE YTRAILPPSF QASFQNDDWI
SSLDSINRNL SAVTSSQLTI TNPKILSGSY DGIVKTYNMS GKVEKQYMGH SAAVKSVKWI
SPTRIVSCGN DQQVRLWKTA YEGVVDQNEE DEEENEANEG DDGDNDMEKI EDGKTLAILE
GHKAPVVDLA VNQQTKRILS AGYDLNVGFW STNYKDMAKI SIPEYDSNVI STSSKKRRKL
ALQDATIRRR SPLSLLLGHT EPVEGVIFDE LDATVGYSVS QDHTIKTWDL VTLRCVDTRT
TGFSLLSILQ LPQVNLIATG SSARHINLHD PRVSASNTNS EVVNTKLVGH TNFVVGLSAS
PHNSNMFASS SHDGTVKVWD IRADKSLYTI TREDGSTKSK IFGVCWDSEI GLISGGEDKR
VQINKGSDIS K
