ID   YTM1_MAGO7              Reviewed;         484 AA.
AC   A4R2Q6; G4MRX3;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-APR-2009, sequence version 2.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Ribosome biogenesis protein YTM1 {ECO:0000255|HAMAP-Rule:MF_03029};
GN   Name=YTM1 {ECO:0000255|HAMAP-Rule:MF_03029}; ORFNames=MGG_02460;
OS   Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS   fungus) (Pyricularia oryzae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX   NCBI_TaxID=242507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX   PubMed=15846337; DOI=10.1038/nature03449;
RA   Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA   Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA   Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA   Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA   Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA   Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT   "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL   Nature 434:980-986(2005).
CC   -!- FUNCTION: Component of the NOP7 complex, which is required for
CC       maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC       ribosome. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC       YTM1. The complex is held together by ERB1, which interacts with NOP7
CC       via its N-terminal domain and with YTM1 via a high-affinity interaction
CC       between the seven-bladed beta-propeller domains of the 2 proteins. The
CC       NOP7 complex associates with the 66S pre-ribosome. Interacts (via UBL
CC       domain) with MDN1 (via VWFA/MIDAS domain). {ECO:0000255|HAMAP-
CC       Rule:MF_03029}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03029}.
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DR   EMBL; CM001231; EHA56642.1; -; Genomic_DNA.
DR   RefSeq; XP_003709254.1; XM_003709206.1.
DR   AlphaFoldDB; A4R2Q6; -.
DR   SMR; A4R2Q6; -.
DR   STRING; 318829.MGG_02460T0; -.
DR   EnsemblFungi; MGG_02460T0; MGG_02460T0; MGG_02460.
DR   GeneID; 2681557; -.
DR   KEGG; mgr:MGG_02460; -.
DR   VEuPathDB; FungiDB:MGG_02460; -.
DR   eggNOG; KOG0313; Eukaryota.
DR   HOGENOM; CLU_000288_57_0_1; -.
DR   InParanoid; A4R2Q6; -.
DR   OMA; VDCTRTK; -.
DR   OrthoDB; 1540178at2759; -.
DR   Proteomes; UP000009058; Chromosome 1.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070545; C:PeBoW complex; IEA:EnsemblFungi.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0051276; P:chromosome organization; IEA:EnsemblFungi.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0110136; P:protein-RNA complex remodeling; IEA:EnsemblFungi.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03029; WDR12; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR012972; NLE.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR028599; WDR12/Ytm1.
DR   Pfam; PF08154; NLE; 1.
DR   Pfam; PF00400; WD40; 2.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..484
FT                   /note="Ribosome biogenesis protein YTM1"
FT                   /id="PRO_0000369592"
FT   REPEAT          121..160
FT                   /note="WD 1"
FT   REPEAT          166..204
FT                   /note="WD 2"
FT   REPEAT          215..254
FT                   /note="WD 3"
FT   REPEAT          289..329
FT                   /note="WD 4"
FT   REPEAT          331..372
FT                   /note="WD 5"
FT   REPEAT          378..418
FT                   /note="WD 6"
FT   REPEAT          448..484
FT                   /note="WD 7"
FT   REGION          11..94
FT                   /note="Ubiquitin-like (UBL) domain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
SQ   SEQUENCE   484 AA;  52188 MW;  E4618FE2BA692E37 CRC64;
     MNATTEQEAI VKVLFTTTEQ GLELPESKRL LLVPADIRRY GLSRVLNSES MLNTAAPIPF
     DFLVNGTFLR TTLEDYLKEN GLPFEKTVTL QYVRSLVPPA YEASFEHDDW VSSVDLLSAT
     SSAGKWSGSS FLQGQDRILS ASYDGLLRIW NGSGQALATS SVVNRGPLCG LKSAKFMSST
     KIAAAGLDRT VRIWDYTEAD DHFSGQLKPT LELYGHRSII ESLGVDGSSR RILTACADGS
     IGLWTTSKKL APEAPTALLP QTYATKRRKG STTSANIIAQ RGALSLIPVH SRPVSAAIFD
     PQNQHTAYSA SQDHTLKVLD LTTSRVVSTI TTSNALMSAC YLSNKSAPLI AAGTSSRNVT
     LIDPRESAAA TSVMTLRGHI NVVSSVSASP DNEYSLVSGS HDGTCRIWDL RSVRPAAGKE
     ETGLGSVGES VYLIERESLG DKKRPLAGEG VKVFDVQWDK TWGIVSGGED KKVQINKGRN
     IISS