ID   YTM1_MALGO              Reviewed;         528 AA.
AC   A8PT44;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Ribosome biogenesis protein YTM1 {ECO:0000255|HAMAP-Rule:MF_03029};
GN   Name=YTM1 {ECO:0000255|HAMAP-Rule:MF_03029}; ORFNames=MGL_0365;
OS   Malassezia globosa (strain ATCC MYA-4612 / CBS 7966) (Dandruff-associated
OS   fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Malasseziomycetes; Malasseziales; Malasseziaceae; Malassezia.
OX   NCBI_TaxID=425265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4612 / CBS 7966;
RX   PubMed=18000048; DOI=10.1073/pnas.0706756104;
RA   Xu J., Saunders C.W., Hu P., Grant R.A., Boekhout T., Kuramae E.E.,
RA   Kronstad J.W., DeAngelis Y.M., Reeder N.L., Johnstone K.R., Leland M.,
RA   Fieno A.M., Begley W.M., Sun Y., Lacey M.P., Chaudhary T., Keough T.,
RA   Chu L., Sears R., Yuan B., Dawson T.L. Jr.;
RT   "Dandruff-associated Malassezia genomes reveal convergent and divergent
RT   virulence traits shared with plant and human fungal pathogens.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:18730-18735(2007).
CC   -!- FUNCTION: Component of the NOP7 complex, which is required for
CC       maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC       ribosome. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC       YTM1. The complex is held together by ERB1, which interacts with NOP7
CC       via its N-terminal domain and with YTM1 via a high-affinity interaction
CC       between the seven-bladed beta-propeller domains of the 2 proteins. The
CC       NOP7 complex associates with the 66S pre-ribosome. Interacts (via UBL
CC       domain) with MDN1 (via VWFA/MIDAS domain). {ECO:0000255|HAMAP-
CC       Rule:MF_03029}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03029}.
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DR   EMBL; AAYY01000001; EDP45376.1; -; Genomic_DNA.
DR   RefSeq; XP_001732590.1; XM_001732538.1.
DR   AlphaFoldDB; A8PT44; -.
DR   SMR; A8PT44; -.
DR   STRING; 425265.A8PT44; -.
DR   EnsemblFungi; EDP45376; EDP45376; MGL_0365.
DR   GeneID; 5856896; -.
DR   KEGG; mgl:MGL_0365; -.
DR   VEuPathDB; FungiDB:MGL_0365; -.
DR   InParanoid; A8PT44; -.
DR   OMA; VDCTRTK; -.
DR   OrthoDB; 1540178at2759; -.
DR   Proteomes; UP000008837; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03029; WDR12; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR012972; NLE.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR028599; WDR12/Ytm1.
DR   Pfam; PF08154; NLE; 1.
DR   Pfam; PF00400; WD40; 3.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..528
FT                   /note="Ribosome biogenesis protein YTM1"
FT                   /id="PRO_0000369593"
FT   REPEAT          136..174
FT                   /note="WD 1"
FT   REPEAT          182..222
FT                   /note="WD 2"
FT   REPEAT          232..278
FT                   /note="WD 3"
FT   REPEAT          334..374
FT                   /note="WD 4"
FT   REPEAT          383..423
FT                   /note="WD 5"
FT   REPEAT          429..469
FT                   /note="WD 6"
FT   REPEAT          489..528
FT                   /note="WD 7"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          33..124
FT                   /note="Ubiquitin-like (UBL) domain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
FT   REGION          276..304
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..32
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   528 AA;  56122 MW;  F554342620B7572D CRC64;
     MSDRPDRVHD QAASSSRDSM TSTPSISSSN APATVPIRLR TSLPGCSIPY VPYMVPVTWR
     RSQLSTLVNK VLATAQGAGH EEASYKAVPF DFIVDGSLLR CSLDEYLEQR GQSAETTLEL
     EYIRSTLPPA FKDAARQDDW VSSVDARHAH RILTASYDGI VRIFDSESLA TSPPQSYTPA
     YASNVSLTSA KWLRNTADAI VTGSMSGTVA VWRVPGTETK SVPVLQAAEL EHHTSPVSSI
     DVAVAATNAS AERATIVSAG WDGSIALWDV PADARFETQE ETGGAPGKKR RKQHGSDARP
     ISSAIITPPP LMVLHHVTPS LGATAARALN TAPTPGPNAR TIAALGDGDQ RIWSAAWDGT
     VKYWDVVAGG GLAGRKQTDK VPLCLDPLQS LSLSSFTTPQ LVCGHMDHSL ALYDFRDAVS
     NAALAMSGAH AAPVSAVKVH PVSAHLFASG AYDGRIKVWD VRSPKQALFA LSEPVSTSSK
     SSHMASSKQP RTKVLGLDWT PDGNALVSGG EDCRVCLYQG QAIGIEHV