ID   YTM1_NEUCR              Reviewed;         487 AA.
AC   Q9C2I5; V5ILF1;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Ribosome biogenesis protein ytm1 {ECO:0000255|HAMAP-Rule:MF_03029};
GN   Name=ytm1; ORFNames=93G11.070, NCU03764;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Component of the NOP7 complex, which is required for
CC       maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC       ribosome. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SUBUNIT: Component of the NOP7 complex, composed of erb1, nop7 and
CC       ytm1. The complex is held together by erb1, which interacts with nop7
CC       via its N-terminal domain and with ytm1 via a high-affinity interaction
CC       between the seven-bladed beta-propeller domains of the 2 proteins. The
CC       NOP7 complex associates with the 66S pre-ribosome. Interacts (via UBL
CC       domain) with rbg-35/mdn1 (via VWFA/MIDAS domain). {ECO:0000255|HAMAP-
CC       Rule:MF_03029}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03029}.
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DR   EMBL; AL513443; CAC28659.1; -; Genomic_DNA.
DR   EMBL; CM002240; ESA42456.1; -; Genomic_DNA.
DR   EMBL; CM002240; ESA42457.1; -; Genomic_DNA.
DR   RefSeq; XP_011394582.1; XM_011396280.1.
DR   RefSeq; XP_011394583.1; XM_011396281.1.
DR   AlphaFoldDB; Q9C2I5; -.
DR   SMR; Q9C2I5; -.
DR   STRING; 5141.EFNCRP00000003292; -.
DR   EnsemblFungi; ESA42456; ESA42456; NCU03764.
DR   EnsemblFungi; ESA42457; ESA42457; NCU03764.
DR   GeneID; 3877276; -.
DR   KEGG; ncr:NCU03764; -.
DR   VEuPathDB; FungiDB:NCU03764; -.
DR   HOGENOM; CLU_000288_57_0_1; -.
DR   InParanoid; Q9C2I5; -.
DR   OMA; VDCTRTK; -.
DR   Proteomes; UP000001805; Chromosome 2, Linkage Group V.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070545; C:PeBoW complex; IBA:GO_Central.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0051276; P:chromosome organization; IEA:EnsemblFungi.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0110136; P:protein-RNA complex remodeling; IEA:EnsemblFungi.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03029; WDR12; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR012972; NLE.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR028599; WDR12/Ytm1.
DR   Pfam; PF08154; NLE; 1.
DR   Pfam; PF00400; WD40; 3.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..487
FT                   /note="Ribosome biogenesis protein ytm1"
FT                   /id="PRO_0000369595"
FT   REPEAT          120..159
FT                   /note="WD 1"
FT   REPEAT          166..204
FT                   /note="WD 2"
FT   REPEAT          217..256
FT                   /note="WD 3"
FT   REPEAT          290..330
FT                   /note="WD 4"
FT   REPEAT          381..421
FT                   /note="WD 5"
FT   REPEAT          452..487
FT                   /note="WD 6"
FT   REGION          11..93
FT                   /note="Ubiquitin-like (UBL) domain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
SQ   SEQUENCE   487 AA;  52303 MW;  EAFE4668FD5709C5 CRC64;
     MDHPTESGAQ VRVTFTTQEE DIQLDESKRQ LLVPADIRRY GLSRILNSES MLDTNSIPFD
     FLVNGSFLRG SLEEYLNANG LSLETNITLQ YVRSLIPPTY EASFEHDDWV SAVDVLSATS
     PAGRWSGDNF QRGQDRILSA SYDGLLRIWD ASGNVIGTSP SGSHGGHTAS IKAAKFLSST
     QIASAGMDRT VRVWKYTESG ESYERRGELK PTLELYGHTS SIDSLEVDGA SKRILTASAD
     GSIGFWTTSK ASAPEVSDSS LLPGAHTSKR RKLATSVTAA QRGPLALMNI HNAPATAAVF
     DPRDRTVAYS VSQDHTVKTI DLTTSSVVST FTTSHALLSL AALPRSSASA PLLACGTSAR
     HITLVDPRTS TAATSVMTLR GHANKVVSLA ANPENEYSLV SGSHDGTCRI WDLRSVRPAT
     KDEGGMGSVS EPVYVIDRES QQGKKKKSSV TGDGCKVFSV VWDQLGIFSG GEDKKVQINK
     GRGVNAE