YTM1_PICGU
ID YTM1_PICGU Reviewed; 453 AA.
AC A5DL92;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Ribosome biogenesis protein YTM1 {ECO:0000255|HAMAP-Rule:MF_03029};
GN Name=YTM1 {ECO:0000255|HAMAP-Rule:MF_03029}; ORFNames=PGUG_04043;
OS Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX NCBI_TaxID=294746;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA Birren B.W., Kellis M., Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC YTM1. The complex is held together by ERB1, which interacts with NOP7
CC via its N-terminal domain and with YTM1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. Interacts (via UBL
CC domain) with MDN1 (via VWFA/MIDAS domain). {ECO:0000255|HAMAP-
CC Rule:MF_03029}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03029}.
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DR EMBL; CH408159; EDK39945.2; -; Genomic_DNA.
DR RefSeq; XP_001483314.1; XM_001483264.1.
DR AlphaFoldDB; A5DL92; -.
DR SMR; A5DL92; -.
DR STRING; 4929.XP_001483314.1; -.
DR PRIDE; A5DL92; -.
DR EnsemblFungi; EDK39945; EDK39945; PGUG_04043.
DR GeneID; 5125120; -.
DR KEGG; pgu:PGUG_04043; -.
DR VEuPathDB; FungiDB:PGUG_04043; -.
DR eggNOG; KOG0313; Eukaryota.
DR HOGENOM; CLU_000288_57_0_1; -.
DR InParanoid; A5DL92; -.
DR OMA; VDCTRTK; -.
DR OrthoDB; 1540178at2759; -.
DR Proteomes; UP000001997; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03029; WDR12; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR012972; NLE.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR028599; WDR12/Ytm1.
DR Pfam; PF08154; NLE; 1.
DR Pfam; PF00400; WD40; 4.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..453
FT /note="Ribosome biogenesis protein YTM1"
FT /id="PRO_0000369597"
FT REPEAT 128..166
FT /note="WD 1"
FT REPEAT 168..206
FT /note="WD 2"
FT REPEAT 218..257
FT /note="WD 3"
FT REPEAT 292..332
FT /note="WD 4"
FT REPEAT 334..373
FT /note="WD 5"
FT REPEAT 380..420
FT /note="WD 6"
FT REPEAT 422..453
FT /note="WD 7"
FT REGION 19..102
FT /note="Ubiquitin-like (UBL) domain"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
FT REGION 112..453
FT /note="Sufficient for interaction with ERB1 and association
FT with 66S pre-ribosomes"
FT /evidence="ECO:0000250"
SQ SEQUENCE 453 AA; 49414 MW; E367B7E80286AE00 CRC64;
MLIAFCTCEI FHLTMTDQVK VRFFTNEEDD LKVSENPIFV PVSLKRYGLS EIVNHLLNDG
ETKKAIPFDF LVDGVLLRTS LQDYLTKQGL STETVIDLQY TRAVLPPSFL ASFTNEDWIS
SIDTINPGHG AVLASNMKLQ ESKILSGSYD GVVRTYNMSG EVESQYIGHS GPVKSVRWIS
PTRIVSAGND HSLRLWKTKL AGVEEGAEDG KTTAILEGHK GPVVDLAVDY KSNKIISAGN
DSVVGVWSTN ASDMSAVTVS EPTGSTMSKK RKKLALQDST IKRRAPLAMM DGHGQPVTGV
CFDVNDKSVI YSASQDHTIK TWDLVTSRCV DTRSTGFSLL SILQLPNLHL VASGSSARHI
NLHDPRASSS TEQVSRKLVG HTNFVVSMAA CPDKDHMFAS ASHDGTVKVW DVRADKAMYT
LGKGGKVFGV SWDPIGIVSG GEDKKIDIYR EAN
