ID   YTM1_PICST              Reviewed;         467 AA.
AC   A3LQ86;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 2.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Ribosome biogenesis protein YTM1 {ECO:0000255|HAMAP-Rule:MF_03029};
GN   Name=YTM1 {ECO:0000255|HAMAP-Rule:MF_03029}; ORFNames=PICST_42488;
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- FUNCTION: Component of the NOP7 complex, which is required for
CC       maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC       ribosome. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC       YTM1. The complex is held together by ERB1, which interacts with NOP7
CC       via its N-terminal domain and with YTM1 via a high-affinity interaction
CC       between the seven-bladed beta-propeller domains of the 2 proteins. The
CC       NOP7 complex associates with the 66S pre-ribosome. Interacts (via UBL
CC       domain) with MDN1 (via VWFA/MIDAS domain). {ECO:0000255|HAMAP-
CC       Rule:MF_03029}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03029}.
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DR   EMBL; CP000496; ABN64638.2; -; Genomic_DNA.
DR   RefSeq; XP_001382667.2; XM_001382630.1.
DR   AlphaFoldDB; A3LQ86; -.
DR   SMR; A3LQ86; -.
DR   STRING; 4924.XP_001382667.2; -.
DR   EnsemblFungi; ABN64638; ABN64638; PICST_42488.
DR   GeneID; 4837223; -.
DR   KEGG; pic:PICST_42488; -.
DR   eggNOG; KOG0313; Eukaryota.
DR   HOGENOM; CLU_000288_57_0_1; -.
DR   InParanoid; A3LQ86; -.
DR   OMA; VDCTRTK; -.
DR   OrthoDB; 1540178at2759; -.
DR   Proteomes; UP000002258; Chromosome 2.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03029; WDR12; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR012972; NLE.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR028599; WDR12/Ytm1.
DR   Pfam; PF08154; NLE; 1.
DR   Pfam; PF00400; WD40; 3.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..467
FT                   /note="Ribosome biogenesis protein YTM1"
FT                   /id="PRO_0000369598"
FT   REPEAT          120..159
FT                   /note="WD 1"
FT   REPEAT          161..199
FT                   /note="WD 2"
FT   REPEAT          216..255
FT                   /note="WD 3"
FT   REPEAT          293..333
FT                   /note="WD 4"
FT   REPEAT          335..374
FT                   /note="WD 5"
FT   REPEAT          382..422
FT                   /note="WD 6"
FT   REPEAT          432..467
FT                   /note="WD 7"
FT   REGION          8..95
FT                   /note="Ubiquitin-like (UBL) domain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
FT   REGION          105..467
FT                   /note="Sufficient for interaction with ERB1 and association
FT                   with 66S pre-ribosomes"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   467 AA;  51536 MW;  4DDFEE51F3BAB5F2 CRC64;
     MSDDKSQIKI KFFTNEEDVS LQVSDAPLYV PVSLKRYGLS EVVNQLLGND GENDDSKPIP
     FDFLIDGVLL RTSIQDYLTK NGLSSETFLS LEYTRAVLPP SFLASFNNED WISSLDTINK
     TLPSVTLSNM MISQPKILSG SYDGIVRTYN MSGNVEKQYV GHSGPIRAVK WVSPTRIVSA
     GNDRQVRLWK TSADDGSIPE EDEEAEDGRT LAILEGHKAP VVALAVENTS NRILSAGYDH
     SIGFWSTNYK EMTTIQPLEY DSNVLSSSSK KRRKMALQDS TIRRRSPLAL LDSHTQPVED
     VIFDNTDATV GYSVSQDHTI KTWDLVTSRC IDTRSTGYSL LSIVQLPKSK LLATGSSARH
     INLHDPRISN NTTEQTTSKL VGHTNFVVSL AASPNNDNMF ASGSHDGTVK VWDIRTDKSL
     YTITRESPEA VKGADKVFAV SWDNEIGIIS GGQDKKIQIN KGSDISK