YTM1_PODAN
ID YTM1_PODAN Reviewed; 487 AA.
AC B2B5V0; A0A090D5C7;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 13-APR-2016, sequence version 2.
DT 25-MAY-2022, entry version 63.
DE RecName: Full=Ribosome biogenesis protein YTM1 {ECO:0000255|HAMAP-Rule:MF_03029};
GN Name=YTM1 {ECO:0000255|HAMAP-Rule:MF_03029}; OrderedLocusNames=Pa_2_5840;
GN ORFNames=PODANS_2_5840;
OS Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383)
OS (Pleurage anserina).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Podosporaceae; Podospora;
OC Podospora anserina.
OX NCBI_TaxID=515849;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S / ATCC MYA-4624 / DSM 980 / FGSC 10383;
RX PubMed=18460219; DOI=10.1186/gb-2008-9-5-r77;
RA Espagne E., Lespinet O., Malagnac F., Da Silva C., Jaillon O., Porcel B.M.,
RA Couloux A., Aury J.-M., Segurens B., Poulain J., Anthouard V.,
RA Grossetete S., Khalili H., Coppin E., Dequard-Chablat M., Picard M.,
RA Contamine V., Arnaise S., Bourdais A., Berteaux-Lecellier V., Gautheret D.,
RA de Vries R.P., Battaglia E., Coutinho P.M., Danchin E.G.J., Henrissat B.,
RA El Khoury R., Sainsard-Chanet A., Boivin A., Pinan-Lucarre B., Sellem C.H.,
RA Debuchy R., Wincker P., Weissenbach J., Silar P.;
RT "The genome sequence of the model ascomycete fungus Podospora anserina.";
RL Genome Biol. 9:R77.1-R77.22(2008).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=S / ATCC MYA-4624 / DSM 980 / FGSC 10383;
RX PubMed=24558260; DOI=10.1534/genetics.113.159988;
RA Grognet P., Bidard F., Kuchly C., Tong L.C.H., Coppin E., Benkhali J.A.,
RA Couloux A., Wincker P., Debuchy R., Silar P.;
RT "Maintaining two mating types: Structure of the mating type locus and its
RT role in heterokaryosis in Podospora anserina.";
RL Genetics 197:421-432(2014).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC YTM1. The complex is held together by ERB1, which interacts with NOP7
CC via its N-terminal domain and with YTM1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. Interacts (via UBL
CC domain) with MDN1 (via VWFA/MIDAS domain). {ECO:0000255|HAMAP-
CC Rule:MF_03029}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03029}.
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DR EMBL; CU640366; CAP73175.1; -; Genomic_DNA.
DR EMBL; FO904937; CDP25578.1; -; Genomic_DNA.
DR RefSeq; XP_001911350.1; XM_001911315.1.
DR AlphaFoldDB; B2B5V0; -.
DR SMR; B2B5V0; -.
DR STRING; 5145.XP_001911350.1; -.
DR EnsemblFungi; CAP73175; CAP73175; PODANS_2_5840.
DR GeneID; 6195422; -.
DR KEGG; pan:PODANSg8392; -.
DR eggNOG; KOG0313; Eukaryota.
DR HOGENOM; CLU_000288_57_0_1; -.
DR OrthoDB; 1540178at2759; -.
DR Proteomes; UP000001197; Chromosome 2.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03029; WDR12; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR012972; NLE.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR028599; WDR12/Ytm1.
DR Pfam; PF08154; NLE; 1.
DR Pfam; PF00400; WD40; 4.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..487
FT /note="Ribosome biogenesis protein YTM1"
FT /id="PRO_0000369599"
FT REPEAT 122..161
FT /note="WD 1"
FT REPEAT 168..206
FT /note="WD 2"
FT REPEAT 217..256
FT /note="WD 3"
FT REPEAT 379..419
FT /note="WD 4"
FT REPEAT 451..487
FT /note="WD 5"
FT REGION 13..95
FT /note="Ubiquitin-like (UBL) domain"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
FT REGION 253..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 294
FT /note="A -> P (in Ref. 1; CAP73175)"
FT /evidence="ECO:0000305"
FT CONFLICT 298
FT /note="V -> F (in Ref. 1; CAP73175)"
FT /evidence="ECO:0000305"
FT CONFLICT 300
FT /note="D -> Y (in Ref. 1; CAP73175)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 487 AA; 52098 MW; 9E9C81648C172FDA CRC64;
MDEPMNDAPG AQVKVTFTTN EADLQLPEEK RQLLVPADIR RYGLSRILNS DLMLDSGSIP
FDFLVNGSFL RSSLEDYLNS EGLSLETNLT LQYVRSLIPP VFEASFEHDD WVSSVDALTA
TSPAGRWSGE NFSRGQERIL SASYDGLLRI WNASGEVLVT APSASHGGHS ASIKAAKFIS
STQIASTGMD RSVRVWKYTD PGASGQAELK PTLELYGHRA SVDSLEVHGP SKRILTASAD
GSVALWSASK SSSPEADASL LPNAHTSKRR KVASSVTTPQ RGPLFLMQIH NAPATAAVFD
PRDHTVGYSV SQDHTVKTLD LTTGSVVANL TLSHSLLSLC AIPRPNGAPL LAVGTSARHI
TLVDPRASAA TTSVMTLRGH TNKVVALAAN PENEYSLVSG SHDGTCRIWD LRSVRPASGG
ESEGGVGGNV SEPVYVFERE SRQGKKKSVA GEGAKVFGVV WDRELGILSG GEDKKVQVNR
GRDVVRE
