ID   YTM1_YEAS7              Reviewed;         460 AA.
AC   A6ZPA9;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Ribosome biogenesis protein YTM1 {ECO:0000255|HAMAP-Rule:MF_03029};
DE   AltName: Full=Microtubule-associated protein YTM1;
GN   Name=YTM1 {ECO:0000255|HAMAP-Rule:MF_03029}; ORFNames=SCY_5324;
OS   Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=307796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJM789;
RX   PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA   Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA   Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA   Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA   Steinmetz L.M.;
RT   "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT   strain YJM789.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC   -!- FUNCTION: Component of the NOP7 complex, which is required for
CC       maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC       ribosome. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC       YTM1. The complex is held together by ERB1, which interacts with NOP7
CC       via its N-terminal domain and with YTM1 via a high-affinity interaction
CC       between the seven-bladed beta-propeller domains of the 2 proteins. The
CC       NOP7 complex associates with the 66S pre-ribosome. Interacts (via UBL
CC       domain) with MDN1 (via VWFA/MIDAS domain). {ECO:0000255|HAMAP-
CC       Rule:MF_03029}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03029}.
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DR   EMBL; AAFW02000032; EDN63599.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6ZPA9; -.
DR   SMR; A6ZPA9; -.
DR   IntAct; A6ZPA9; 2.
DR   MINT; A6ZPA9; -.
DR   PRIDE; A6ZPA9; -.
DR   EnsemblFungi; EDN63599; EDN63599; SCY_5324.
DR   HOGENOM; CLU_000288_57_0_1; -.
DR   Proteomes; UP000007060; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03029; WDR12; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR012972; NLE.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR028599; WDR12/Ytm1.
DR   Pfam; PF08154; NLE; 1.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Repeat; Ribosome biogenesis; rRNA processing; WD repeat.
FT   CHAIN           1..460
FT                   /note="Ribosome biogenesis protein YTM1"
FT                   /id="PRO_0000369604"
FT   REPEAT          101..140
FT                   /note="WD 1"
FT   REPEAT          142..180
FT                   /note="WD 2"
FT   REPEAT          206..244
FT                   /note="WD 3"
FT   REPEAT          285..325
FT                   /note="WD 4"
FT   REPEAT          327..366
FT                   /note="WD 5"
FT   REPEAT          373..413
FT                   /note="WD 6"
FT   REPEAT          424..460
FT                   /note="WD 7"
FT   REGION          8..89
FT                   /note="Ubiquitin-like (UBL) domain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
FT   REGION          99..460
FT                   /note="Sufficient for interaction with ERB1 and association
FT                   with 66S pre-ribosomes"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   460 AA;  51359 MW;  DBC26738651433C4 CRC64;
     MTEDKSQVKI RFFTREKDEL LHVQDTPMYA PISLKRYGLS EIVNHLLGSE KPVPFDFLIE
     GELLRTSLHD YLTKKGLSSE ASLNVEYTRA ILPPSYLNSF SNEDWVSSLD VGDGSKHIIS
     GSYDGIVRTW DLSGNVQKQY SGHSGPIRAV KYISNTRLVS AGNDRTLRLW KTKNDDLKLT
     SQQQAQEDDD DEVNIEDGKT LAILEGHKAP VVSIDVSDNS RILSASYDNS IGFWSTIYKE
     MTVVDPLEDI NNPNNKISTA ARKRRKLTMK DGTIRRRAPL SLLESHTAPV EQVIFDSTDN
     TVGYSVSQDH TIKTWDLVTA RCIDTRTTSY SLLSIAQLST LNLLACGSSA RHITLHDPRV
     GASSKVTQQQ LIGHKNFVSS LDTCPENEYI LCSGSHDGTV KVWDVRSTSP MYTITREDKS
     VQKGVNDKVF AVKWAEKVGI ISAGQDKKIQ INKGDNIFKN