CBY1_BOVIN
ID CBY1_BOVIN Reviewed; 127 AA.
AC Q8MJK1; Q0P5H0;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Protein chibby homolog 1;
DE AltName: Full=Cytosolic leucine-rich protein;
DE AltName: Full=PIGEA-14;
DE AltName: Full=PKD2 interactor, Golgi and endoplasmic reticulum-associated 1;
GN Name=CBY1; Synonyms=CBY, PGEA1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Huang C.-H.;
RT "A conserved cytosolic leucine-rich protein (LRP) in vertebrate animals.";
RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal cerebellum;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-
CC catenin and inhibiting beta-catenin-mediated transcriptional activation
CC through competition with TCF/LEF transcription factors. Has also been
CC shown to play a role in regulating the intracellular trafficking of
CC polycystin-2/PKD2 and possibly of other intracellular proteins.
CC Promotes adipocyte and cardiomyocyte differentiation.
CC {ECO:0000250|UniProtKB:Q9Y3M2}.
CC -!- SUBUNIT: Homodimer. Interacts with polycystin-2/PKD2 and GM130.
CC Interacts with the C-terminal region of CTNNB1. Interacts (C-terminus)
CC with TCIM (C-terminus), TCIM competes with CTNNB1 for the interaction
CC with CBY1. Interacts with FAM92A; this interaction facilitates
CC targeting of FAM92A to cilium basal body. Interacts with CIBAR2.
CC {ECO:0000250|UniProtKB:Q9Y3M2}.
CC -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:Q9Y3M2}.
CC Cytoplasm, cytoskeleton, cilium basal body
CC {ECO:0000250|UniProtKB:Q9Y3M2}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome, centriole
CC {ECO:0000250|UniProtKB:Q9Y3M2}. Golgi apparatus
CC {ECO:0000250|UniProtKB:Q9Y3M2}. Golgi apparatus, trans-Golgi network
CC {ECO:0000250|UniProtKB:Q9Y3M2}. Note=Nuclear, in a punctate manner (By
CC similarity). {ECO:0000250|UniProtKB:Q9Y3M2}.
CC -!- MISCELLANEOUS: 'Chibby' is Japanese for 'small'; the gene was so named
CC for the RNAi phenotype seen in flies.
CC -!- SIMILARITY: Belongs to the chibby family. {ECO:0000305}.
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DR EMBL; AF393210; AAM73678.1; -; mRNA.
DR EMBL; BC120055; AAI20056.1; -; mRNA.
DR RefSeq; NP_777164.1; NM_174739.4.
DR RefSeq; XP_005207367.1; XM_005207310.3.
DR RefSeq; XP_005207368.1; XM_005207311.1.
DR RefSeq; XP_010804004.1; XM_010805702.2.
DR RefSeq; XP_010804005.1; XM_010805703.2.
DR RefSeq; XP_010804006.1; XM_010805704.2.
DR RefSeq; XP_015326859.1; XM_015471373.1.
DR AlphaFoldDB; Q8MJK1; -.
DR SMR; Q8MJK1; -.
DR STRING; 9913.ENSBTAP00000008651; -.
DR PaxDb; Q8MJK1; -.
DR Ensembl; ENSBTAT00000008651; ENSBTAP00000008651; ENSBTAG00000006588.
DR GeneID; 282859; -.
DR KEGG; bta:282859; -.
DR CTD; 25776; -.
DR VEuPathDB; HostDB:ENSBTAG00000006588; -.
DR VGNC; VGNC:26822; CBY1.
DR eggNOG; ENOG502S6C8; Eukaryota.
DR GeneTree; ENSGT00940000153137; -.
DR HOGENOM; CLU_134504_0_0_1; -.
DR InParanoid; Q8MJK1; -.
DR OMA; IWMHSAR; -.
DR OrthoDB; 1492677at2759; -.
DR TreeFam; TF324419; -.
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000006588; Expressed in retina and 108 other tissues.
DR ExpressionAtlas; Q8MJK1; baseline and differential.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0055007; P:cardiac muscle cell differentiation; ISS:UniProtKB.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR GO; GO:0045444; P:fat cell differentiation; ISS:UniProtKB.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IBA:GO_Central.
DR CDD; cd07429; Cby_like; 1.
DR InterPro; IPR028118; Chibby_fam.
DR Pfam; PF14645; Chibby; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium biogenesis/degradation; Coiled coil; Cytoplasm;
KW Cytoskeleton; Differentiation; Golgi apparatus; Nucleus; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..127
FT /note="Protein chibby homolog 1"
FT /id="PRO_0000089387"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 60..112
FT /note="Minimal region for the interaction with PKD2"
FT /evidence="ECO:0000250"
FT COILED 68..125
FT /evidence="ECO:0000255"
FT COMPBIAS 11..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 9
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8K4I6"
FT MOD_RES 20
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3M2"
SQ SEQUENCE 127 AA; 14509 MW; 057DCCB64F96E19D CRC64;
MPLFGSTFSP KKTPPRKSAS LSNLHNLDRS TREVELGLDY GTPTMNLAGQ SLKFENGQWI
AETGISGGVD RREAQRLRRR NQQLEEENNL LRLKVDILLD MLSETTAESH LMEKELDELK
SVSRRRK
