CBY2_BOVIN
ID CBY2_BOVIN Reviewed; 455 AA.
AC A6QQS3;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Protein chibby homolog 2 {ECO:0000305};
DE AltName: Full=Spermatid-associated protein;
GN Name=CBY2; Synonyms=SPERT;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-253 (ISOFORM 1).
RC STRAIN=Hereford; TISSUE=Testis;
RA Moore S.S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
RA Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
RA Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
RA Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A.,
RA Holt R., Jones S.J., Marra M.A.;
RT "Bovine genome sequencing program: full-length cDNA sequencing.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homodimer. Binds to NEK1 (By similarity). {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A6QQS3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A6QQS3-2; Sequence=VSP_028671, VSP_028672;
CC -!- SIMILARITY: Belongs to the chibby family. SPERT subfamily.
CC {ECO:0000305}.
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DR EMBL; DT854277; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC149972; AAI49973.1; -; mRNA.
DR RefSeq; NP_001095767.1; NM_001102297.2. [A6QQS3-2]
DR RefSeq; XP_005213736.1; XM_005213679.3. [A6QQS3-1]
DR AlphaFoldDB; A6QQS3; -.
DR SMR; A6QQS3; -.
DR STRING; 9913.ENSBTAP00000024729; -.
DR PaxDb; A6QQS3; -.
DR Ensembl; ENSBTAT00000053702; ENSBTAP00000050226; ENSBTAG00000018580. [A6QQS3-2]
DR GeneID; 616053; -.
DR KEGG; bta:616053; -.
DR CTD; 220082; -.
DR VEuPathDB; HostDB:ENSBTAG00000018580; -.
DR eggNOG; ENOG502S6IZ; Eukaryota.
DR GeneTree; ENSGT00940000153137; -.
DR HOGENOM; CLU_041289_0_0_1; -.
DR InParanoid; A6QQS3; -.
DR OMA; WSIWEEN; -.
DR OrthoDB; 1015941at2759; -.
DR TreeFam; TF324419; -.
DR Proteomes; UP000009136; Chromosome 12.
DR Bgee; ENSBTAG00000018580; Expressed in spermatid and 12 other tissues.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
DR InterPro; IPR028118; Chibby_fam.
DR InterPro; IPR026655; SPERT.
DR PANTHER; PTHR21533:SF13; PTHR21533:SF13; 1.
DR Pfam; PF14645; Chibby; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..455
FT /note="Protein chibby homolog 2"
FT /id="PRO_0000307290"
FT REGION 267..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 331..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 160..197
FT /evidence="ECO:0000255"
FT COILED 240..266
FT /evidence="ECO:0000255"
FT COILED 350..421
FT /evidence="ECO:0000255"
FT COMPBIAS 292..311
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 41
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AXV6"
FT MOD_RES 86
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AXV6"
FT MOD_RES 89
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AXV6"
FT MOD_RES 97
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AXV6"
FT MOD_RES 124
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AXV6"
FT MOD_RES 144
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AXV6"
FT MOD_RES 148
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AXV6"
FT MOD_RES 150
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AXV6"
FT MOD_RES 211
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AXV6"
FT MOD_RES 225
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AXV6"
FT MOD_RES 276
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AXV6"
FT MOD_RES 332
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AXV6"
FT VAR_SEQ 1..34
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_028671"
FT VAR_SEQ 35..52
FT /note="RDTRSESLEIPINVVLPQ -> MAVQPEGLKCRVEESNAE (in isoform
FT 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_028672"
SQ SEQUENCE 455 AA; 52473 MW; 1F0ABDB92D8E1D8C CRC64;
MSPLECSECF GDQLLHRTYT WHLTLHSRPN FTRKRDTRSE SLEIPINVVL PQRGTAEPFL
RLHNLYPTPR CARQAALPRL SRRVVSQHSY PLNRFSSVPL DPMERPTSQA DLELDYNPPR
VQLSDEMFVF QDGRWVSENC RLQSPYFSPS SSFHHKLHHK RLAKECLLQE NKTLREENRA
LREENRMLRK ENKILQVFWE EHQAALGRDD SRASSPLLHK DNASSLEAMK KETALQAHRG
RENSTLQLLR EENRALQQLL EQRKAYWAQP DEKAASTEEI KPISSPHEEP HGLLPDPGPG
LPSPFEEPKG LPAPPDDSKT LRALREMVST LSAQPGEEVG KGGPGLPDGS QSLELLREMN
QALQALREEN QSLQVLRDEN RLLQEENRAL HALREEHRLF QEENKALWEN NKLKLQQKLV
IDTVTEVTAR MEMLIEELYA FMPAKSKDPK KPSRV
