ID   YTTP_BACSU              Reviewed;         207 AA.
AC   O34970;
DT   22-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Probable HTH-type transcriptional regulator YttP;
DE   AltName: Full=Stress response protein YttP;
GN   Name=yttP; OrderedLocusNames=BSU29630;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9387221; DOI=10.1099/00221287-143-11-3431;
RA   Lapidus A., Galleron N., Sorokin A., Ehrlich S.D.;
RT   "Sequencing and functional annotation of the Bacillus subtilis genes in the
RT   200 kb rrnB-dnaB region.";
RL   Microbiology 143:3431-3441(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   TRANSCRIPTIONAL REGULATION.
RX   PubMed=11988534; DOI=10.1099/00221287-148-5-1593;
RA   Pragai Z., Harwood C.R.;
RT   "Regulatory interactions between the Pho and sigma(B)-dependent general
RT   stress regulons of Bacillus subtilis.";
RL   Microbiology 148:1593-1602(2002).
RN   [4]
RP   REVIEW, AND GENE FAMILY.
RX   PubMed=15944459; DOI=10.1128/mmbr.69.2.326-356.2005;
RA   Ramos J.L., Martinez-Bueno M., Molina-Henares A.J., Teran W., Watanabe K.,
RA   Zhang X., Gallegos M.T., Brennan R., Tobes R.;
RT   "The TetR family of transcriptional repressors.";
RL   Microbiol. Mol. Biol. Rev. 69:326-356(2005).
CC   -!- INDUCTION: By phosphate starvation, via the PhoP/PhoR two-component
CC       regulatory system. {ECO:0000269|PubMed:11988534}.
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DR   EMBL; AF008220; AAC00305.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB14941.1; -; Genomic_DNA.
DR   PIR; H70001; H70001.
DR   RefSeq; NP_390841.1; NC_000964.3.
DR   RefSeq; WP_003229313.1; NZ_JNCM01000036.1.
DR   PDB; 6MJ1; X-ray; 2.60 A; A=1-207.
DR   PDBsum; 6MJ1; -.
DR   AlphaFoldDB; O34970; -.
DR   SMR; O34970; -.
DR   STRING; 224308.BSU29630; -.
DR   PaxDb; O34970; -.
DR   PRIDE; O34970; -.
DR   EnsemblBacteria; CAB14941; CAB14941; BSU_29630.
DR   GeneID; 937327; -.
DR   KEGG; bsu:BSU29630; -.
DR   PATRIC; fig|224308.179.peg.3219; -.
DR   eggNOG; COG1309; Bacteria.
DR   InParanoid; O34970; -.
DR   OMA; FFYRELS; -.
DR   BioCyc; BSUB:BSU29630-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS01081; HTH_TETR_1; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; DNA-binding; Reference proteome; Repressor; Stress response;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..207
FT                   /note="Probable HTH-type transcriptional regulator YttP"
FT                   /id="PRO_0000070652"
FT   DOMAIN          3..63
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        26..45
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   HELIX           5..19
FT                   /evidence="ECO:0007829|PDB:6MJ1"
FT   TURN            22..24
FT                   /evidence="ECO:0007829|PDB:6MJ1"
FT   HELIX           27..34
FT                   /evidence="ECO:0007829|PDB:6MJ1"
FT   HELIX           38..45
FT                   /evidence="ECO:0007829|PDB:6MJ1"
FT   HELIX           48..71
FT                   /evidence="ECO:0007829|PDB:6MJ1"
FT   TURN            72..76
FT                   /evidence="ECO:0007829|PDB:6MJ1"
FT   HELIX           79..96
FT                   /evidence="ECO:0007829|PDB:6MJ1"
FT   HELIX           98..106
FT                   /evidence="ECO:0007829|PDB:6MJ1"
FT   HELIX           114..137
FT                   /evidence="ECO:0007829|PDB:6MJ1"
FT   TURN            138..141
FT                   /evidence="ECO:0007829|PDB:6MJ1"
FT   STRAND          143..146
FT                   /evidence="ECO:0007829|PDB:6MJ1"
FT   HELIX           148..160
FT                   /evidence="ECO:0007829|PDB:6MJ1"
FT   HELIX           161..163
FT                   /evidence="ECO:0007829|PDB:6MJ1"
FT   HELIX           166..174
FT                   /evidence="ECO:0007829|PDB:6MJ1"
FT   HELIX           183..196
FT                   /evidence="ECO:0007829|PDB:6MJ1"
SQ   SEQUENCE   207 AA;  24388 MW;  27C3FEB7D8EB7EE4 CRC64;
     MKVSTKDKII ESAVMLFNQK GFSGTSVREI AKSADVNVAH ISYYFKGKGG LMEHLVSEFY
     EGYSKTLETA ASNISTQSTQ EQLLQLVFDI LSYQHNHRQL TRFVYREVTI DSTLIREIMS
     TYLMKEKYIF QLIIEEGEKQ REYLTLPLPH FILQLKSLLM MPYLQPQYIS EVLYMQPHEP
     YFYKMYFEEI KIWIRSVFRT GDVALTN