CBY2_HUMAN
ID CBY2_HUMAN Reviewed; 448 AA.
AC Q8NA61; A8K8I5; Q8NHV2;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Protein chibby homolog 2 {ECO:0000305};
DE AltName: Full=Spermatid-associated protein;
GN Name=CBY2 {ECO:0000312|HGNC:HGNC:30720}; Synonyms=SPERT;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=33536340; DOI=10.1073/pnas.2018355118;
RA Shimada K., Park S., Miyata H., Yu Z., Morohoshi A., Oura S., Matzuk M.M.,
RA Ikawa M.;
RT "ARMC12 regulates spatiotemporal mitochondrial dynamics during
RT spermiogenesis and is required for male fertility.";
RL Proc. Natl. Acad. Sci. U.S.A. 118:0-0(2021).
CC -!- SUBUNIT: Homodimer. Binds to NEK1 (By similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC Q8NA61; P12814: ACTN1; NbExp=3; IntAct=EBI-741724, EBI-351710;
CC Q8NA61; Q8TER5-2: ARHGEF40; NbExp=3; IntAct=EBI-741724, EBI-10275150;
CC Q8NA61; Q9H6L4: ARMC7; NbExp=3; IntAct=EBI-741724, EBI-742909;
CC Q8NA61; Q9H6X5: C19orf44; NbExp=3; IntAct=EBI-741724, EBI-7112211;
CC Q8NA61; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-741724, EBI-8643161;
CC Q8NA61; Q8IYE0-2: CCDC146; NbExp=3; IntAct=EBI-741724, EBI-10247802;
CC Q8NA61; Q9NVL8: CCDC198; NbExp=3; IntAct=EBI-741724, EBI-10238351;
CC Q8NA61; P51959: CCNG1; NbExp=3; IntAct=EBI-741724, EBI-3905829;
CC Q8NA61; Q9UJX2: CDC23; NbExp=3; IntAct=EBI-741724, EBI-396137;
CC Q8NA61; Q9C0F1: CEP44; NbExp=4; IntAct=EBI-741724, EBI-744115;
CC Q8NA61; Q8IYX8-2: CEP57L1; NbExp=3; IntAct=EBI-741724, EBI-10181988;
CC Q8NA61; Q96GE4: CEP95; NbExp=3; IntAct=EBI-741724, EBI-372775;
CC Q8NA61; Q9NX63: CHCHD3; NbExp=3; IntAct=EBI-741724, EBI-743375;
CC Q8NA61; Q9UKJ5: CHIC2; NbExp=3; IntAct=EBI-741724, EBI-741528;
CC Q8NA61; P61024: CKS1B; NbExp=3; IntAct=EBI-741724, EBI-456371;
CC Q8NA61; Q8NE01: CNNM3; NbExp=3; IntAct=EBI-741724, EBI-741032;
CC Q8NA61; Q9UBT7: CTNNAL1; NbExp=3; IntAct=EBI-741724, EBI-514206;
CC Q8NA61; O95147: DUSP14; NbExp=3; IntAct=EBI-741724, EBI-3922653;
CC Q8NA61; Q8IYY4: DZIP1L; NbExp=3; IntAct=EBI-741724, EBI-10264440;
CC Q8NA61; O60573: EIF4E2; NbExp=3; IntAct=EBI-741724, EBI-398610;
CC Q8NA61; Q14241: ELOA; NbExp=3; IntAct=EBI-741724, EBI-742350;
CC Q8NA61; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-741724, EBI-744099;
CC Q8NA61; Q3B820: FAM161A; NbExp=3; IntAct=EBI-741724, EBI-719941;
CC Q8NA61; O43559: FRS3; NbExp=3; IntAct=EBI-741724, EBI-725515;
CC Q8NA61; Q8N9W4-2: GOLGA6L2; NbExp=3; IntAct=EBI-741724, EBI-10268729;
CC Q8NA61; Q96CS2: HAUS1; NbExp=3; IntAct=EBI-741724, EBI-2514791;
CC Q8NA61; Q9BVG8: KIFC3; NbExp=5; IntAct=EBI-741724, EBI-2125614;
CC Q8NA61; Q6P597: KLC3; NbExp=3; IntAct=EBI-741724, EBI-1643885;
CC Q8NA61; Q6PJG3: LATS1; NbExp=3; IntAct=EBI-741724, EBI-10253976;
CC Q8NA61; Q96BZ8: LENG1; NbExp=3; IntAct=EBI-741724, EBI-726510;
CC Q8NA61; P25800: LMO1; NbExp=3; IntAct=EBI-741724, EBI-8639312;
CC Q8NA61; P25791: LMO2; NbExp=3; IntAct=EBI-741724, EBI-739696;
CC Q8NA61; Q8TAP4: LMO3; NbExp=3; IntAct=EBI-741724, EBI-742259;
CC Q8NA61; Q9H204: MED28; NbExp=3; IntAct=EBI-741724, EBI-514199;
CC Q8NA61; Q9H7H0: METTL17; NbExp=4; IntAct=EBI-741724, EBI-749353;
CC Q8NA61; P40692: MLH1; NbExp=6; IntAct=EBI-741724, EBI-744248;
CC Q8NA61; P00540: MOS; NbExp=3; IntAct=EBI-741724, EBI-1757866;
CC Q8NA61; Q7Z2X4: PID1; NbExp=3; IntAct=EBI-741724, EBI-10256685;
CC Q8NA61; Q13526: PIN1; NbExp=3; IntAct=EBI-741724, EBI-714158;
CC Q8NA61; Q494U1: PLEKHN1; NbExp=3; IntAct=EBI-741724, EBI-10241513;
CC Q8NA61; Q6NYC8: PPP1R18; NbExp=3; IntAct=EBI-741724, EBI-2557469;
CC Q8NA61; P32969: RPL9P9; NbExp=3; IntAct=EBI-741724, EBI-358122;
CC Q8NA61; Q14D33: RTP5; NbExp=3; IntAct=EBI-741724, EBI-10217913;
CC Q8NA61; Q06455-4: RUNX1T1; NbExp=3; IntAct=EBI-741724, EBI-10224192;
CC Q8NA61; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-741724, EBI-748391;
CC Q8NA61; Q08AM8: SH3RF2; NbExp=3; IntAct=EBI-741724, EBI-10225873;
CC Q8NA61; Q8N0S2: SYCE1; NbExp=3; IntAct=EBI-741724, EBI-6872807;
CC Q8NA61; Q8N8B7: TCEANC; NbExp=3; IntAct=EBI-741724, EBI-954696;
CC Q8NA61; Q8IYF3: TEX11; NbExp=3; IntAct=EBI-741724, EBI-742397;
CC Q8NA61; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-741724, EBI-5235829;
CC Q8NA61; Q9BZW7: TSGA10; NbExp=3; IntAct=EBI-741724, EBI-744794;
CC Q8NA61; P40222: TXLNA; NbExp=3; IntAct=EBI-741724, EBI-359793;
CC Q8NA61; Q8N3L3: TXLNB; NbExp=3; IntAct=EBI-741724, EBI-6116822;
CC Q8NA61; Q53FD0: ZC2HC1C; NbExp=3; IntAct=EBI-741724, EBI-740767;
CC Q8NA61; Q96NC0: ZMAT2; NbExp=3; IntAct=EBI-741724, EBI-2682299;
CC Q8NA61; Q8TBZ8: ZNF564; NbExp=3; IntAct=EBI-741724, EBI-10273713;
CC Q8NA61; Q9P0T4: ZNF581; NbExp=3; IntAct=EBI-741724, EBI-745520;
CC Q8NA61; Q8N720: ZNF655; NbExp=4; IntAct=EBI-741724, EBI-625509;
CC Q8NA61; B2R6J3; NbExp=3; IntAct=EBI-741724, EBI-10175524;
CC Q8NA61-2; Q13155: AIMP2; NbExp=5; IntAct=EBI-11524851, EBI-745226;
CC Q8NA61-2; Q00994: BEX3; NbExp=3; IntAct=EBI-11524851, EBI-741753;
CC Q8NA61-2; Q9H6X5-2: C19orf44; NbExp=3; IntAct=EBI-11524851, EBI-12061599;
CC Q8NA61-2; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-11524851, EBI-8643161;
CC Q8NA61-2; Q8NA61-2: CBY2; NbExp=5; IntAct=EBI-11524851, EBI-11524851;
CC Q8NA61-2; Q8IYE0: CCDC146; NbExp=3; IntAct=EBI-11524851, EBI-10749669;
CC Q8NA61-2; Q8N715: CCDC185; NbExp=3; IntAct=EBI-11524851, EBI-740814;
CC Q8NA61-2; Q2TAC2-2: CCDC57; NbExp=3; IntAct=EBI-11524851, EBI-10961624;
CC Q8NA61-2; Q8TD31-3: CCHCR1; NbExp=5; IntAct=EBI-11524851, EBI-10175300;
CC Q8NA61-2; Q16543: CDC37; NbExp=3; IntAct=EBI-11524851, EBI-295634;
CC Q8NA61-2; Q07002: CDK18; NbExp=3; IntAct=EBI-11524851, EBI-746238;
CC Q8NA61-2; Q53EZ4: CEP55; NbExp=3; IntAct=EBI-11524851, EBI-747776;
CC Q8NA61-2; P61024: CKS1B; NbExp=3; IntAct=EBI-11524851, EBI-456371;
CC Q8NA61-2; Q8NE01: CNNM3; NbExp=3; IntAct=EBI-11524851, EBI-741032;
CC Q8NA61-2; Q9UIA0: CYTH4; NbExp=3; IntAct=EBI-11524851, EBI-11521003;
CC Q8NA61-2; O60941-5: DTNB; NbExp=3; IntAct=EBI-11524851, EBI-11984733;
CC Q8NA61-2; Q8IYY4: DZIP1L; NbExp=5; IntAct=EBI-11524851, EBI-10264440;
CC Q8NA61-2; Q8N7B9-2: EFCAB3; NbExp=3; IntAct=EBI-11524851, EBI-11958551;
CC Q8NA61-2; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-11524851, EBI-744099;
CC Q8NA61-2; Q3B820: FAM161A; NbExp=5; IntAct=EBI-11524851, EBI-719941;
CC Q8NA61-2; A1XBS5-3: FAM92A; NbExp=3; IntAct=EBI-11524851, EBI-12348777;
CC Q8NA61-2; O95363: FARS2; NbExp=3; IntAct=EBI-11524851, EBI-2513774;
CC Q8NA61-2; Q96EF6: FBXO17; NbExp=3; IntAct=EBI-11524851, EBI-2510157;
CC Q8NA61-2; Q8TAE8: GADD45GIP1; NbExp=3; IntAct=EBI-11524851, EBI-372506;
CC Q8NA61-2; Q9NYA3: GOLGA6A; NbExp=3; IntAct=EBI-11524851, EBI-11163335;
CC Q8NA61-2; O75031: HSF2BP; NbExp=3; IntAct=EBI-11524851, EBI-7116203;
CC Q8NA61-2; Q8WYH8: ING5; NbExp=6; IntAct=EBI-11524851, EBI-488533;
CC Q8NA61-2; Q9H1K1: ISCU; NbExp=3; IntAct=EBI-11524851, EBI-1047335;
CC Q8NA61-2; Q6ZU52: KIAA0408; NbExp=5; IntAct=EBI-11524851, EBI-739493;
CC Q8NA61-2; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-11524851, EBI-14069005;
CC Q8NA61-2; Q8TBB1: LNX1; NbExp=7; IntAct=EBI-11524851, EBI-739832;
CC Q8NA61-2; Q96EZ8: MCRS1; NbExp=3; IntAct=EBI-11524851, EBI-348259;
CC Q8NA61-2; Q9H204: MED28; NbExp=3; IntAct=EBI-11524851, EBI-514199;
CC Q8NA61-2; Q9H7H0-2: METTL17; NbExp=3; IntAct=EBI-11524851, EBI-11098807;
CC Q8NA61-2; Q8IVT4: MGC50722; NbExp=3; IntAct=EBI-11524851, EBI-14086479;
CC Q8NA61-2; P40692: MLH1; NbExp=11; IntAct=EBI-11524851, EBI-744248;
CC Q8NA61-2; Q96EY8: MMAB; NbExp=3; IntAct=EBI-11524851, EBI-7825413;
CC Q8NA61-2; P00540: MOS; NbExp=3; IntAct=EBI-11524851, EBI-1757866;
CC Q8NA61-2; Q9HC98-4: NEK6; NbExp=3; IntAct=EBI-11524851, EBI-11750983;
CC Q8NA61-2; Q9Y5B8: NME7; NbExp=3; IntAct=EBI-11524851, EBI-744782;
CC Q8NA61-2; Q96HA8: NTAQ1; NbExp=5; IntAct=EBI-11524851, EBI-741158;
CC Q8NA61-2; O43482: OIP5; NbExp=3; IntAct=EBI-11524851, EBI-536879;
CC Q8NA61-2; Q13526: PIN1; NbExp=3; IntAct=EBI-11524851, EBI-714158;
CC Q8NA61-2; Q494U1-3: PLEKHN1; NbExp=3; IntAct=EBI-11524851, EBI-12014286;
CC Q8NA61-2; O15160: POLR1C; NbExp=5; IntAct=EBI-11524851, EBI-1055079;
CC Q8NA61-2; O75145: PPFIA3; NbExp=3; IntAct=EBI-11524851, EBI-1763225;
CC Q8NA61-2; Q96KQ4: PPP1R13B; NbExp=3; IntAct=EBI-11524851, EBI-1105153;
CC Q8NA61-2; Q99633: PRPF18; NbExp=3; IntAct=EBI-11524851, EBI-2798416;
CC Q8NA61-2; Q9P2K3-2: RCOR3; NbExp=3; IntAct=EBI-11524851, EBI-1504830;
CC Q8NA61-2; A0A0S2Z4G9: RNF6; NbExp=3; IntAct=EBI-11524851, EBI-16428950;
CC Q8NA61-2; Q06455-2: RUNX1T1; NbExp=3; IntAct=EBI-11524851, EBI-11984663;
CC Q8NA61-2; Q9BWG6: SCNM1; NbExp=5; IntAct=EBI-11524851, EBI-748391;
CC Q8NA61-2; O75971-2: SNAPC5; NbExp=5; IntAct=EBI-11524851, EBI-12004298;
CC Q8NA61-2; Q99909: SSX3; NbExp=3; IntAct=EBI-11524851, EBI-10295431;
CC Q8NA61-2; Q8N0S2: SYCE1; NbExp=7; IntAct=EBI-11524851, EBI-6872807;
CC Q8NA61-2; Q9BSW7: SYT17; NbExp=3; IntAct=EBI-11524851, EBI-745392;
CC Q8NA61-2; Q15560: TCEA2; NbExp=3; IntAct=EBI-11524851, EBI-710310;
CC Q8NA61-2; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-11524851, EBI-11955057;
CC Q8NA61-2; Q9BT92: TCHP; NbExp=3; IntAct=EBI-11524851, EBI-740781;
CC Q8NA61-2; Q8IYF3-3: TEX11; NbExp=3; IntAct=EBI-11524851, EBI-11523345;
CC Q8NA61-2; Q8N7C3: TRIML2; NbExp=3; IntAct=EBI-11524851, EBI-11059915;
CC Q8NA61-2; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-11524851, EBI-10241197;
CC Q8NA61-2; P42681: TXK; NbExp=3; IntAct=EBI-11524851, EBI-7877438;
CC Q8NA61-2; P40222: TXLNA; NbExp=3; IntAct=EBI-11524851, EBI-359793;
CC Q8NA61-2; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-11524851, EBI-739895;
CC Q8NA61-2; Q68DK2-5: ZFYVE26; NbExp=3; IntAct=EBI-11524851, EBI-8656416;
CC Q8NA61-2; P15622-3: ZNF250; NbExp=3; IntAct=EBI-11524851, EBI-10177272;
CC Q8NA61-2; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-11524851, EBI-740727;
CC Q8NA61-2; Q8TBZ8: ZNF564; NbExp=3; IntAct=EBI-11524851, EBI-10273713;
CC Q8NA61-2; Q7Z3I7: ZNF572; NbExp=3; IntAct=EBI-11524851, EBI-10172590;
CC Q8NA61-2; Q9P0T4: ZNF581; NbExp=3; IntAct=EBI-11524851, EBI-745520;
CC Q8NA61-2; A0A0S2Z5X4: ZNF688; NbExp=3; IntAct=EBI-11524851, EBI-16429014;
CC Q8NA61-2; Q96H86: ZNF764; NbExp=3; IntAct=EBI-11524851, EBI-745775;
CC Q8NA61-2; A8K8V0: ZNF785; NbExp=3; IntAct=EBI-11524851, EBI-3925400;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8NA61-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NA61-2; Sequence=VSP_028673, VSP_028674;
CC -!- TISSUE SPECIFICITY: Testis-specific. {ECO:0000269|PubMed:33536340}.
CC -!- SIMILARITY: Belongs to the chibby family. SPERT subfamily.
CC {ECO:0000305}.
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DR EMBL; AK093129; BAC04067.1; -; mRNA.
DR EMBL; AK292350; BAF85039.1; -; mRNA.
DR EMBL; AL139320; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC027609; AAH27609.1; -; mRNA.
DR CCDS; CCDS66540.1; -. [Q8NA61-2]
DR CCDS; CCDS9399.1; -. [Q8NA61-1]
DR RefSeq; NP_001273270.1; NM_001286341.1.
DR RefSeq; NP_001273271.1; NM_001286342.1. [Q8NA61-2]
DR RefSeq; NP_689932.1; NM_152719.2. [Q8NA61-1]
DR AlphaFoldDB; Q8NA61; -.
DR SMR; Q8NA61; -.
DR BioGRID; 128627; 144.
DR IntAct; Q8NA61; 130.
DR MINT; Q8NA61; -.
DR STRING; 9606.ENSP00000309189; -.
DR iPTMnet; Q8NA61; -.
DR PhosphoSitePlus; Q8NA61; -.
DR BioMuta; SPERT; -.
DR DMDM; 74751135; -.
DR EPD; Q8NA61; -.
DR MassIVE; Q8NA61; -.
DR PaxDb; Q8NA61; -.
DR PeptideAtlas; Q8NA61; -.
DR PRIDE; Q8NA61; -.
DR ProteomicsDB; 72645; -. [Q8NA61-1]
DR ProteomicsDB; 72646; -. [Q8NA61-2]
DR Antibodypedia; 42238; 67 antibodies from 15 providers.
DR DNASU; 220082; -.
DR Ensembl; ENST00000310521.6; ENSP00000309189.1; ENSG00000174015.10. [Q8NA61-1]
DR Ensembl; ENST00000378966.3; ENSP00000368249.3; ENSG00000174015.10. [Q8NA61-2]
DR Ensembl; ENST00000610924.1; ENSP00000480148.1; ENSG00000174015.10. [Q8NA61-2]
DR GeneID; 220082; -.
DR KEGG; hsa:220082; -.
DR MANE-Select; ENST00000310521.6; ENSP00000309189.1; NM_152719.3; NP_689932.1.
DR UCSC; uc001van.3; human. [Q8NA61-1]
DR CTD; 220082; -.
DR DisGeNET; 220082; -.
DR GeneCards; CBY2; -.
DR HGNC; HGNC:30720; CBY2.
DR HPA; ENSG00000174015; Tissue enriched (testis).
DR MIM; 618614; gene.
DR neXtProt; NX_Q8NA61; -.
DR OpenTargets; ENSG00000174015; -.
DR VEuPathDB; HostDB:ENSG00000174015; -.
DR eggNOG; ENOG502S6IZ; Eukaryota.
DR GeneTree; ENSGT00940000153137; -.
DR HOGENOM; CLU_041289_0_0_1; -.
DR InParanoid; Q8NA61; -.
DR OMA; WSIWEEN; -.
DR OrthoDB; 1015941at2759; -.
DR PhylomeDB; Q8NA61; -.
DR TreeFam; TF324419; -.
DR PathwayCommons; Q8NA61; -.
DR SignaLink; Q8NA61; -.
DR BioGRID-ORCS; 220082; 11 hits in 1068 CRISPR screens.
DR GenomeRNAi; 220082; -.
DR Pharos; Q8NA61; Tbio.
DR PRO; PR:Q8NA61; -.
DR Proteomes; UP000005640; Chromosome 13.
DR RNAct; Q8NA61; protein.
DR Bgee; ENSG00000174015; Expressed in left testis and 32 other tissues.
DR ExpressionAtlas; Q8NA61; baseline and differential.
DR Genevisible; Q8NA61; HS.
DR GO; GO:0031410; C:cytoplasmic vesicle; ISS:HGNC-UCL.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR CDD; cd07429; Cby_like; 1.
DR InterPro; IPR028118; Chibby_fam.
DR InterPro; IPR026655; SPERT.
DR PANTHER; PTHR21533:SF13; PTHR21533:SF13; 1.
DR Pfam; PF14645; Chibby; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..448
FT /note="Protein chibby homolog 2"
FT /id="PRO_0000307291"
FT REGION 270..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 164..198
FT /evidence="ECO:0000255"
FT COILED 242..267
FT /evidence="ECO:0000255"
FT COILED 356..414
FT /evidence="ECO:0000255"
FT MOD_RES 41
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AXV6"
FT MOD_RES 86
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AXV6"
FT MOD_RES 89
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AXV6"
FT MOD_RES 97
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AXV6"
FT MOD_RES 124
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AXV6"
FT MOD_RES 144
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AXV6"
FT MOD_RES 148
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AXV6"
FT MOD_RES 150
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AXV6"
FT MOD_RES 212
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AXV6"
FT MOD_RES 225
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AXV6"
FT MOD_RES 335
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AXV6"
FT MOD_RES 338
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AXV6"
FT VAR_SEQ 1..36
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_028673"
FT VAR_SEQ 37..52
FT /note="TRSESLEIPISVVLPQ -> MQPEGLKCRMEESNAE (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_028674"
FT VARIANT 329
FT /note="K -> E (in dbSNP:rs7317245)"
FT /id="VAR_054064"
SQ SEQUENCE 448 AA; 51570 MW; D59271CFE59F8863 CRC64;
MSPLECSECF GDQLLHRTYT WQLTLHSRPN YTRKRDTRSE SLEIPISVVL PQRGTAEPFP
RLHNLYSTPR CAQQAALPRL SRRMASQHSY PLNRFSSVPL DPMERPMSQA DLELDYNPPR
VQLSDEMFVF QDGRWVNENC RLQSPYFSPS ASFHHKLHHK RLAKECMLQE ENKSLREENK
ALREENRMLS KENKILQVFW EEHKASLGRE ESRAPSPLLH KDSASLEVVK KDHVALQVPR
GKEDSTLQLL REENRALQQL LEQKQAYWAQ AEDTAAPAEE SKPAPSPHEE PCSPGLLQDQ
GSGLSSRFEE PKGPPARQED SKELRALRKM VSNMSGPSGE EEAKVGPGLP DGCQPLQLLR
EMRQALQALL KENRLLQEEN RTLQVLRAEH RGFQEENKAL WENNKLKLQQ KLVIDTVTEV
TARMEMLIEE LYAFMPARSQ DPKKPSRV
