YTYK2_DICDI
ID YTYK2_DICDI Reviewed; 918 AA.
AC Q54R58;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Probable tyrosine-protein kinase DDB_G0283397;
DE EC=2.7.10.2;
GN ORFNames=DDB_G0283397;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU10028};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Tyr protein
CC kinase family. {ECO:0000305}.
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DR EMBL; AAFI02000055; EAL65683.1; -; Genomic_DNA.
DR RefSeq; XP_639033.1; XM_633941.1.
DR AlphaFoldDB; Q54R58; -.
DR SMR; Q54R58; -.
DR STRING; 44689.DDB0229872; -.
DR PaxDb; Q54R58; -.
DR EnsemblProtists; EAL65683; EAL65683; DDB_G0283397.
DR GeneID; 8624058; -.
DR KEGG; ddi:DDB_G0283397; -.
DR dictyBase; DDB_G0283397; -.
DR eggNOG; KOG0192; Eukaryota.
DR HOGENOM; CLU_317490_0_0_1; -.
DR InParanoid; Q54R58; -.
DR OMA; SLAWMAP; -.
DR PRO; PR:Q54R58; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; SSF50978; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW ATP-binding; Kinase; Nucleotide-binding; Reference proteome; Repeat;
KW Transferase; Tyrosine-protein kinase; WD repeat.
FT CHAIN 1..918
FT /note="Probable tyrosine-protein kinase DDB_G0283397"
FT /id="PRO_0000355146"
FT DOMAIN 177..445
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REPEAT 626..667
FT /note="WD 1"
FT REPEAT 684..722
FT /note="WD 2"
FT REPEAT 724..765
FT /note="WD 3"
FT REPEAT 776..820
FT /note="WD 4"
FT REPEAT 823..862
FT /note="WD 5"
FT REGION 1..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 457..504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..81
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 307
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT ECO:0000255|PROSITE-ProRule:PRU10028"
FT BINDING 183..191
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 204
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ SEQUENCE 918 AA; 102616 MW; 2E67BA9688A5F45D CRC64;
MFNNDKDDNN QGNENNENNK INIKTSIDMG NYINSSSLVE SFGSGSNRNN DKSEDVEYDD
DDDDDDDEIA STEEEKESDL DSDSDLAPTQ IIVDDSDDFY NNNNGGGGGG GNEDISSTSP
TLITSNSFND KINQIFSRGG SSLNSSFLNN GENKINFKQL VKLKSTLKKH EIPSRELTVE
KEIGQGFFGK VYKARWRGKS VALKKITLIK FRDLTETEIF DKEVSIMSKL CHPTCVMFIG
ACSLDGPSND RSIIMEYMEG GSLRRLLDEK SSYHLPPSLQ LSIARDIAEG MNYLHTNFKE
GPIVHRDLTS SNILLNSSYT VAKINDFGLS KEMKPGPTEM TAAMGSLAWM APECFKAENY
TEKVDVYSFA IILWEIVTCR DPYNGMEPLR LAFLASVEDY RLPLNGFPPY WVELISKCWN
ITPSLRPSFK EILQILNQIE SDPLFLNLNL NCSSNNTSSG STSTSSGSSS SSDNNLTKSS
ESNNNLRESN INNQIKSNKN SSKNGYYAQD INDYSLSMQV ETKNCIYNNV SDNVNNNNNN
NNNNNNDNDF FKSSFTKKSF LSNNNYNNNN NNINNKNNNT NNLNDNLIIK SLNHISEQNS
FLVSYQDSNI VKYFSLDNES LTSTLQMEQS VVCMKYQIIN EKVFLVVAMS NNNISLFELK
KTDFSGSANS PTTLLPIKVI KCDEQRHTIK DITWNGTHVI TSSFKDSSIQ IWDLEKSLYP
ISKMDNGGVG ILSIDSQSHQ PLMISGDSDG KVKLWDIRNS HCFRTLTHSP PSSSSGGSIG
VDSVLFRSPH AVRDPIILTG SSKDCKFKVW NMYSSTCLNS FQSHNKDLLG IHRNQSSQQM
ITWSSEGTIS LFNSGNNINN QNNQNNNNDC GNDNDSVEFS KVLNVNSMMS NEPLQSAQII
SKNRIIFSSK NKFYSIIA
