ID   YU58_BRUSU              Reviewed;         172 AA.
AC   Q9RPX3; G0KEQ6; Q7CEG5;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Type IV secretion system putative outer membrane lipoprotein BRA0058/BS1330_II0058;
DE   Flags: Precursor;
GN   OrderedLocusNames=BRA0058, BS1330_II0058;
OS   Brucella suis biovar 1 (strain 1330).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=204722;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=1330;
RX   PubMed=10510235; DOI=10.1046/j.1365-2958.1999.01569.x;
RA   O'Callaghan D., Cazevieille C., Allardet-Servent A., Boschiroli M.L.,
RA   Bourg G., Foulongne V., Frutos P., Kulakov Y., Ramuz M.;
RT   "A homologue of the Agrobacterium tumefaciens VirB and Bordetella pertussis
RT   Ptl type IV secretion systems is essential for intracellular survival of
RT   Brucella suis.";
RL   Mol. Microbiol. 33:1210-1220(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND EXPRESSION CONDITIONS.
RC   STRAIN=1330;
RX   PubMed=11830669; DOI=10.1073/pnas.032514299;
RA   Boschiroli M.L., Ouahrani-Bettache S., Foulongne V., Michaux-Charachon S.,
RA   Bourg G., Allardet-Servent A., Cazevieille C., Liautard J.P., Ramuz M.,
RA   O'Callaghan D.;
RT   "The Brucella suis virB operon is induced intracellularly in macrophages.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:1544-1549(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1330;
RX   PubMed=12271122; DOI=10.1073/pnas.192319099;
RA   Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F.,
RA   Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J.,
RA   Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R.,
RA   Nelson W.C., Ayodeji B., Kraul M., Shetty J., Malek J.A., Van Aken S.E.,
RA   Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L.,
RA   Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.;
RT   "The Brucella suis genome reveals fundamental similarities between animal
RT   and plant pathogens and symbionts.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1330;
RX   PubMed=22038969; DOI=10.1128/jb.06181-11;
RA   Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.;
RT   "Revised genome sequence of Brucella suis 1330.";
RL   J. Bacteriol. 193:6410-6410(2011).
CC   -!- FUNCTION: The VirB system could be required for the establishment of
CC       the replication niche in the host.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000255|PROSITE-ProRule:PRU00303}.
CC   -!- INDUCTION: Specifically induced within macrophages by phagosome
CC       acidification. Induced at 37 degrees Celsius in minimal medium,
CC       suggesting that nutritional stress is a regulating signal.
CC   -!- MISCELLANEOUS: Transcription of the operon is maximal in early
CC       exponential phase.
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DR   EMBL; AF141604; AAD56622.1; -; Genomic_DNA.
DR   EMBL; AE014292; AAN33270.1; -; Genomic_DNA.
DR   EMBL; CP002998; AEM19550.1; -; Genomic_DNA.
DR   RefSeq; WP_004689960.1; NZ_KN046805.1.
DR   AlphaFoldDB; Q9RPX3; -.
DR   SMR; Q9RPX3; -.
DR   EnsemblBacteria; AEM19550; AEM19550; BS1330_II0058.
DR   GeneID; 45053155; -.
DR   GeneID; 55591795; -.
DR   KEGG; bms:BRA0058; -.
DR   KEGG; bsi:BS1330_II0058; -.
DR   PATRIC; fig|204722.21.peg.2313; -.
DR   HOGENOM; CLU_125850_0_0_5; -.
DR   OMA; SNDYREP; -.
DR   PhylomeDB; Q9RPX3; -.
DR   Proteomes; UP000007104; Chromosome II.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.30.1330.60; -; 1.
DR   InterPro; IPR006665; OmpA-like.
DR   InterPro; IPR036737; OmpA-like_sf.
DR   SUPFAM; SSF103088; SSF103088; 1.
DR   PROSITE; PS51123; OMPA_2; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   2: Evidence at transcript level;
KW   Cell outer membrane; Lipoprotein; Membrane; Palmitate; Signal; Virulence.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           16..172
FT                   /note="Type IV secretion system putative outer membrane
FT                   lipoprotein BRA0058/BS1330_II0058"
FT                   /id="PRO_0000291448"
FT   DOMAIN          58..172
FT                   /note="OmpA-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00473"
FT   LIPID           16
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           16
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ   SEQUENCE   172 AA;  18991 MW;  0A71CF3C0BB074C8 CRC64;
     MRTLVMVACA VSLAACSSPP KPPTVSGRHR IPINSPAAQE ELRLQVFPQE PTAQATMWPA
     RPPKQTVSVY FPQDVTVFRP TSAQINQLHT LLWPVPKHIN VRGLTDNNCP PPGDTQVARV
     RALAIYNWLI NQGVSASRIT ISYAPVKDYA SNAPLSPGRV LNRRVDIEIL RK