ID   CBY2_RAT                Reviewed;         447 AA.
AC   Q6AXV6;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Protein chibby homolog 2 {ECO:0000305};
DE   AltName: Full=Spermatid-associated protein;
GN   Name=Cby2; Synonyms=Spert;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41; SER-85; SER-88; SER-96;
RP   SER-123; SER-143; SER-147; SER-149; SER-211; SER-224; SER-272; SER-275;
RP   SER-333 AND SER-336, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP   ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- SUBUNIT: Homodimer. Binds to NEK1 (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the chibby family. SPERT subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC079300; AAH79300.1; -; mRNA.
DR   RefSeq; NP_001017506.1; NM_001017506.1.
DR   AlphaFoldDB; Q6AXV6; -.
DR   SMR; Q6AXV6; -.
DR   STRING; 10116.ENSRNOP00000066296; -.
DR   iPTMnet; Q6AXV6; -.
DR   PhosphoSitePlus; Q6AXV6; -.
DR   PaxDb; Q6AXV6; -.
DR   PRIDE; Q6AXV6; -.
DR   Ensembl; ENSRNOT00000072138; ENSRNOP00000066296; ENSRNOG00000047413.
DR   GeneID; 498572; -.
DR   KEGG; rno:498572; -.
DR   CTD; 220082; -.
DR   RGD; 1561044; Spert.
DR   eggNOG; ENOG502S6IZ; Eukaryota.
DR   GeneTree; ENSGT00940000153137; -.
DR   HOGENOM; CLU_041289_0_0_1; -.
DR   InParanoid; Q6AXV6; -.
DR   OMA; WSIWEEN; -.
DR   OrthoDB; 1015941at2759; -.
DR   PhylomeDB; Q6AXV6; -.
DR   PRO; PR:Q6AXV6; -.
DR   Proteomes; UP000002494; Chromosome 15.
DR   Bgee; ENSRNOG00000047413; Expressed in testis and 1 other tissue.
DR   GO; GO:0031410; C:cytoplasmic vesicle; ISO:RGD.
DR   CDD; cd07429; Cby_like; 1.
DR   InterPro; IPR028118; Chibby_fam.
DR   InterPro; IPR026655; SPERT.
DR   PANTHER; PTHR21533:SF13; PTHR21533:SF13; 1.
DR   Pfam; PF14645; Chibby; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Phosphoprotein; Reference proteome.
FT   CHAIN           1..447
FT                   /note="Protein chibby homolog 2"
FT                   /id="PRO_0000307294"
FT   REGION          208..244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          266..320
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          164..197
FT                   /evidence="ECO:0000255"
FT   COILED          237..264
FT                   /evidence="ECO:0000255"
FT   COILED          354..412
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        266..319
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         41
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         85
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         88
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         96
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         123
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         143
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         147
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         149
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         211
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         224
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         272
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         275
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         333
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         336
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
SQ   SEQUENCE   447 AA;  52009 MW;  9FE9118048BB1F1E CRC64;
     MSPLECSECF GDQLMHRTYT WHLTLHSRPN FTRKREIRSE SLEIPINVIL PQRGTEPFLR
     LHNLYTTPRC SRQAAMPRIS RRVASQHSYP LNRFSSMPFD PMERPTSQAD LELDYNPPRV
     QLSDEMFVFQ DGRWVNESCR LQSPYFSPSS SFHHKLHHKR MAKEYLLQEE NKSLRDENRA
     LRDENKALRK ENKILQVFWE EHKVTLGHEE SQTSSPLLHK DTTSQEVVKK DNATLPAQRS
     KENTLQFIRE ENRALQQLLE QRQAYWAQAE ESATSAEEGK PTSSPKEEPH NSGLLPDQST
     SHSSHFEEPK ASPTTQEDSK TLRALREMVT NLSGPSGEEE GKAGPNLTDS AQPLQLLREM
     NQALQALREE NRLLQEENRA LHAMREEHRV FQEENKALWE NNKLKLQQRL VIDTVTEVTA
     RMEMLIEELY AFMPAKNNKD PKKPSRV