ID   CC014_HUMAN             Reviewed;         128 AA.
AC   Q9HBI5; B2R9U0;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Uncharacterized protein C3orf14;
GN   Name=C3orf14; ORFNames=HT021;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Hypothalamus;
RX   PubMed=10931946; DOI=10.1073/pnas.160270997;
RA   Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X.,
RA   Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W.,
RA   Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M., Zhou J., Xu S.-H., Gu J.,
RA   Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z.,
RA   Chen M.-D., Chen J.-L.;
RT   "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis
RT   and full-length cDNA cloning.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Thalamus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
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DR   EMBL; AF236158; AAG09750.1; -; mRNA.
DR   EMBL; AK313915; BAG36637.1; -; mRNA.
DR   EMBL; CH471055; EAW65400.1; -; Genomic_DNA.
DR   EMBL; BC017772; AAH17772.1; -; mRNA.
DR   CCDS; CCDS2896.1; -.
DR   RefSeq; NP_001278870.1; NM_001291941.1.
DR   RefSeq; NP_001278871.1; NM_001291942.1.
DR   RefSeq; NP_065736.1; NM_020685.4.
DR   RefSeq; XP_016862420.1; XM_017006931.1.
DR   AlphaFoldDB; Q9HBI5; -.
DR   SMR; Q9HBI5; -.
DR   BioGRID; 121516; 9.
DR   IntAct; Q9HBI5; 2.
DR   STRING; 9606.ENSP00000418086; -.
DR   iPTMnet; Q9HBI5; -.
DR   PhosphoSitePlus; Q9HBI5; -.
DR   BioMuta; C3orf14; -.
DR   DMDM; 68565304; -.
DR   EPD; Q9HBI5; -.
DR   MassIVE; Q9HBI5; -.
DR   MaxQB; Q9HBI5; -.
DR   PaxDb; Q9HBI5; -.
DR   PeptideAtlas; Q9HBI5; -.
DR   PRIDE; Q9HBI5; -.
DR   ProteomicsDB; 81561; -.
DR   Antibodypedia; 54678; 66 antibodies from 10 providers.
DR   DNASU; 57415; -.
DR   Ensembl; ENST00000232519.9; ENSP00000232519.5; ENSG00000114405.11.
DR   Ensembl; ENST00000462069.6; ENSP00000419977.1; ENSG00000114405.11.
DR   Ensembl; ENST00000494481.5; ENSP00000418086.1; ENSG00000114405.11.
DR   Ensembl; ENST00000542214.2; ENSP00000438275.1; ENSG00000114405.11.
DR   GeneID; 57415; -.
DR   KEGG; hsa:57415; -.
DR   MANE-Select; ENST00000462069.6; ENSP00000419977.1; NM_001291941.3; NP_001278870.1.
DR   UCSC; uc003dlf.4; human.
DR   CTD; 57415; -.
DR   GeneCards; C3orf14; -.
DR   HGNC; HGNC:25024; C3orf14.
DR   HPA; ENSG00000114405; Low tissue specificity.
DR   neXtProt; NX_Q9HBI5; -.
DR   OpenTargets; ENSG00000114405; -.
DR   PharmGKB; PA134883066; -.
DR   VEuPathDB; HostDB:ENSG00000114405; -.
DR   eggNOG; ENOG502S7A9; Eukaryota.
DR   GeneTree; ENSGT00390000005214; -.
DR   HOGENOM; CLU_133336_0_0_1; -.
DR   InParanoid; Q9HBI5; -.
DR   OMA; IGVENEN; -.
DR   OrthoDB; 1643090at2759; -.
DR   PhylomeDB; Q9HBI5; -.
DR   TreeFam; TF335879; -.
DR   PathwayCommons; Q9HBI5; -.
DR   SignaLink; Q9HBI5; -.
DR   BioGRID-ORCS; 57415; 8 hits in 1040 CRISPR screens.
DR   ChiTaRS; C3orf14; human.
DR   GenomeRNAi; 57415; -.
DR   Pharos; Q9HBI5; Tdark.
DR   PRO; PR:Q9HBI5; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; Q9HBI5; protein.
DR   Bgee; ENSG00000114405; Expressed in pons and 192 other tissues.
DR   ExpressionAtlas; Q9HBI5; baseline and differential.
DR   Genevisible; Q9HBI5; HS.
DR   InterPro; IPR028006; DUF4570.
DR   PANTHER; PTHR14286; PTHR14286; 1.
DR   Pfam; PF15134; DUF4570; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..128
FT                   /note="Uncharacterized protein C3orf14"
FT                   /id="PRO_0000089388"
SQ   SEQUENCE   128 AA;  15007 MW;  9046B046B0ABD901 CRC64;
     MTSLFAQEIR LSKRHEEIVS QRLMLLQQME NKLGDQHTEK ASQLQTVETA FKRNLSLLKD
     IEAAEKSLQT RIHPLPRPEV VSLETRYWAS VEEYIPKWEQ FLLGRAPYPF AVENQNEAEN
     TIQNEAQR