CC018_HUMAN
ID CC018_HUMAN Reviewed; 162 AA.
AC Q9UK00; C9JNP0;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Uncharacterized protein C3orf18;
DE AltName: Full=Protein G20;
GN Name=C3orf18;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT VAL-162.
RA Duh F.-M., Wei M.-H., Minna J.D., Lerman M.I.;
RT "A novel human cDNA, g20, that is homozygously deleted in small cell lung
RT cancer and located to 3p21.3.";
RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT VAL-162.
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT VAL-162.
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT VAL-162.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9UK00-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9UK00-2; Sequence=VSP_044880;
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DR EMBL; AF188706; AAF01050.1; -; mRNA.
DR EMBL; AK308074; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AL833938; CAD38793.1; -; mRNA.
DR EMBL; AC096920; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC034766; AAH34766.1; -; mRNA.
DR CCDS; CCDS2829.1; -. [Q9UK00-1]
DR CCDS; CCDS54589.1; -. [Q9UK00-2]
DR RefSeq; NP_001165211.1; NM_001171740.2. [Q9UK00-1]
DR RefSeq; NP_001165212.1; NM_001171741.2. [Q9UK00-1]
DR RefSeq; NP_001165214.2; NM_001171743.2. [Q9UK00-2]
DR RefSeq; NP_057294.2; NM_016210.4. [Q9UK00-1]
DR RefSeq; XP_011532092.1; XM_011533790.1. [Q9UK00-2]
DR RefSeq; XP_016862036.1; XM_017006547.1. [Q9UK00-2]
DR AlphaFoldDB; Q9UK00; -.
DR SMR; Q9UK00; -.
DR BioGRID; 119342; 118.
DR STRING; 9606.ENSP00000349732; -.
DR iPTMnet; Q9UK00; -.
DR PhosphoSitePlus; Q9UK00; -.
DR BioMuta; C3orf18; -.
DR DMDM; 317373334; -.
DR MassIVE; Q9UK00; -.
DR PaxDb; Q9UK00; -.
DR PeptideAtlas; Q9UK00; -.
DR PRIDE; Q9UK00; -.
DR ProteomicsDB; 10999; -.
DR ProteomicsDB; 84698; -. [Q9UK00-1]
DR Antibodypedia; 2263; 92 antibodies from 16 providers.
DR DNASU; 51161; -.
DR Ensembl; ENST00000357203.8; ENSP00000349732.3; ENSG00000088543.15. [Q9UK00-1]
DR Ensembl; ENST00000426034.5; ENSP00000387606.1; ENSG00000088543.15. [Q9UK00-1]
DR Ensembl; ENST00000441239.5; ENSP00000414124.1; ENSG00000088543.15. [Q9UK00-2]
DR Ensembl; ENST00000449241.5; ENSP00000404913.1; ENSG00000088543.15. [Q9UK00-1]
DR GeneID; 51161; -.
DR KEGG; hsa:51161; -.
DR MANE-Select; ENST00000357203.8; ENSP00000349732.3; NM_016210.5; NP_057294.2.
DR UCSC; uc003dar.4; human. [Q9UK00-1]
DR CTD; 51161; -.
DR GeneCards; C3orf18; -.
DR HGNC; HGNC:24837; C3orf18.
DR HPA; ENSG00000088543; Low tissue specificity.
DR neXtProt; NX_Q9UK00; -.
DR OpenTargets; ENSG00000088543; -.
DR PharmGKB; PA134941482; -.
DR VEuPathDB; HostDB:ENSG00000088543; -.
DR eggNOG; ENOG502RZ00; Eukaryota.
DR GeneTree; ENSGT00410000025882; -.
DR HOGENOM; CLU_134497_1_0_1; -.
DR InParanoid; Q9UK00; -.
DR OMA; WFSSHPP; -.
DR OrthoDB; 1453896at2759; -.
DR PhylomeDB; Q9UK00; -.
DR TreeFam; TF332764; -.
DR PathwayCommons; Q9UK00; -.
DR BioGRID-ORCS; 51161; 12 hits in 1063 CRISPR screens.
DR GenomeRNAi; 51161; -.
DR Pharos; Q9UK00; Tbio.
DR PRO; PR:Q9UK00; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q9UK00; protein.
DR Bgee; ENSG00000088543; Expressed in right hemisphere of cerebellum and 184 other tissues.
DR ExpressionAtlas; Q9UK00; baseline and differential.
DR Genevisible; Q9UK00; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR042351; C3orf18-like.
DR PANTHER; PTHR15868; PTHR15868; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..162
FT /note="Uncharacterized protein C3orf18"
FT /id="PRO_0000228841"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 59..78
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044880"
FT VARIANT 8
FT /note="A -> D (in dbSNP:rs386598)"
FT /id="VAR_025720"
FT VARIANT 162
FT /note="A -> V (in dbSNP:rs1034405)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:17974005,
FT ECO:0000269|Ref.1"
FT /id="VAR_025721"
SQ SEQUENCE 162 AA; 17468 MW; D5B5DEFFE0E06D6E CRC64;
MNSRTASARG WFSSRPPTSE SDLEPATDGP ASETTTLSPE ATTFNDTRIP DAAGGTAGVG
TMLLSFGIIT VIGLAVALVL YIRKKKRLEK LRHQLMPMYN FDPTEEQDEL EQELLEHGRD
AASVQAATSV QAMQGKTTLP SQGPLQRPSR LVFTDVANAI HA
