YUC10_ARATH
ID YUC10_ARATH Reviewed; 383 AA.
AC Q9FVQ0;
DT 02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Probable indole-3-pyruvate monooxygenase YUCCA10;
DE EC=1.14.13.168;
DE AltName: Full=Flavin-containing monooxygenase YUCCA10;
GN Name=YUC10; Synonyms=YUCCA10; OrderedLocusNames=At1g48910;
GN ORFNames=F27K7.7;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia;
RA Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16818609; DOI=10.1101/gad.1415106;
RA Cheng Y., Dai X., Zhao Y.;
RT "Auxin biosynthesis by the YUCCA flavin monooxygenases controls the
RT formation of floral organs and vascular tissues in Arabidopsis.";
RL Genes Dev. 20:1790-1799(2006).
RN [5]
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=17704214; DOI=10.1105/tpc.107.053009;
RA Cheng Y., Dai X., Zhao Y.;
RT "Auxin synthesized by the YUCCA flavin monooxygenases is essential for
RT embryogenesis and leaf formation in Arabidopsis.";
RL Plant Cell 19:2430-2439(2007).
RN [6]
RP GENE FAMILY.
RC STRAIN=cv. Columbia;
RX PubMed=17461789; DOI=10.1111/j.1365-313x.2007.03101.x;
RA Hansen B.G., Kliebenstein D.J., Halkier B.A.;
RT "Identification of a flavin-monooxygenase as the S-oxygenating enzyme in
RT aliphatic glucosinolate biosynthesis in Arabidopsis.";
RL Plant J. 50:902-910(2007).
RN [7]
RP INDUCTION.
RX PubMed=22109847; DOI=10.1007/s00425-011-1552-3;
RA Lee M., Jung J.H., Han D.Y., Seo P.J., Park W.J., Park C.M.;
RT "Activation of a flavin monooxygenase gene YUCCA7 enhances drought
RT resistance in Arabidopsis.";
RL Planta 235:923-938(2012).
CC -!- FUNCTION: Involved in auxin biosynthesis.
CC {ECO:0000269|PubMed:17704214}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + indole-3-pyruvate + NADPH + O2 = (indol-3-yl)acetate +
CC CO2 + H2O + NADP(+); Xref=Rhea:RHEA:34331, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:17640, ChEBI:CHEBI:30854, ChEBI:CHEBI:57783,
CC ChEBI:CHEBI:58349; EC=1.14.13.168;
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC -!- PATHWAY: Plant hormone metabolism; auxin biosynthesis.
CC -!- DEVELOPMENTAL STAGE: Expression relatively broad during early stages of
CC embryogenesis and more restricted to discrete groups of cells in mature
CC embryos. Later, expression mainly restricted to the cotyledons and the
CC apical meristem. {ECO:0000269|PubMed:17704214}.
CC -!- INDUCTION: Up-regulated by drought. {ECO:0000269|PubMed:22109847}.
CC -!- SIMILARITY: Belongs to the FMO family. {ECO:0000305}.
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DR EMBL; AC084414; AAG29745.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE32365.1; -; Genomic_DNA.
DR EMBL; DQ056487; AAY78644.1; -; mRNA.
DR PIR; H96526; H96526.
DR RefSeq; NP_175321.1; NM_103784.2.
DR AlphaFoldDB; Q9FVQ0; -.
DR SMR; Q9FVQ0; -.
DR STRING; 3702.AT1G48910.1; -.
DR PaxDb; Q9FVQ0; -.
DR PRIDE; Q9FVQ0; -.
DR ProteomicsDB; 232327; -.
DR EnsemblPlants; AT1G48910.1; AT1G48910.1; AT1G48910.
DR GeneID; 841313; -.
DR Gramene; AT1G48910.1; AT1G48910.1; AT1G48910.
DR KEGG; ath:AT1G48910; -.
DR Araport; AT1G48910; -.
DR TAIR; locus:2028558; AT1G48910.
DR eggNOG; KOG1399; Eukaryota.
DR HOGENOM; CLU_006909_2_1_1; -.
DR InParanoid; Q9FVQ0; -.
DR OMA; KFFPNHW; -.
DR OrthoDB; 405736at2759; -.
DR PhylomeDB; Q9FVQ0; -.
DR UniPathway; UPA00151; -.
DR PRO; PR:Q9FVQ0; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9FVQ0; baseline and differential.
DR Genevisible; Q9FVQ0; AT.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IBA:GO_Central.
DR GO; GO:0103075; F:indole-3-pyruvate monooxygenase activity; IEA:UniProtKB-EC.
DR GO; GO:0004497; F:monooxygenase activity; IBA:GO_Central.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0009851; P:auxin biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0009723; P:response to ethylene; IEP:TAIR.
DR Gene3D; 3.50.50.60; -; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR000960; Flavin_mOase.
DR PIRSF; PIRSF000332; FMO; 1.
DR SUPFAM; SSF51905; SSF51905; 1.
PE 2: Evidence at transcript level;
KW Auxin biosynthesis; FAD; Flavoprotein; Monooxygenase; NADP; Oxidoreductase;
KW Reference proteome.
FT CHAIN 1..383
FT /note="Probable indole-3-pyruvate monooxygenase YUCCA10"
FT /id="PRO_0000400077"
FT BINDING 9..14
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000255"
FT BINDING 177..182
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000255"
SQ SEQUENCE 383 AA; 42387 MW; DBF1EF4562252091 CRC64;
METVVVIVGA GPAGLATSVC LNQHSIPNVI LEKEDIYASL WKKRAYDRLK LHLAKEFCQL
PFMPHGREVP TFMSKELFVN YLDAYVARFD INPRYNRTVK SSTFDESNNK WRVVAENTVT
GETEVYWSEF LVVATGENGD GNIPMVEGID TFGGEIMHSS EYKSGRDFKD KNVLVVGGGN
SGMEISFDLC NFGANTTILI RTPRHVVTKE VIHLGMTLLK YAPVAMVDTL VTTMAKILYG
DLSKYGLFRP KQGPFATKLF TGKAPVIDVG TVEKIRDGEI QVINGGIGSI NGKTLTFENG
HKQDFDAIVF ATGYKSSVCN WLEDYEYVMK KDGFPKAPMP KHWKGEKNLY CAGFSRKGIA
GGAEDAMSVA DDIRSILATL KNN
