YUC3_ARATH
ID YUC3_ARATH Reviewed; 437 AA.
AC O23024;
DT 02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Probable indole-3-pyruvate monooxygenase YUCCA3;
DE EC=1.14.13.168;
DE AltName: Full=Flavin-containing monooxygenase YUCCA3;
GN Name=YUC3; Synonyms=YUCCA3; OrderedLocusNames=At1g04610; ORFNames=T1G11.14;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11209081; DOI=10.1126/science.291.5502.306;
RA Zhao Y., Christensen S.K., Fankhauser C., Cashman J.R., Cohen J.D.,
RA Weigel D., Chory J.;
RT "A role for flavin monooxygenase-like enzymes in auxin biosynthesis.";
RL Science 291:306-309(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Kim C.J., Chen H., Cheuk R., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF Clones.";
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16818609; DOI=10.1101/gad.1415106;
RA Cheng Y., Dai X., Zhao Y.;
RT "Auxin biosynthesis by the YUCCA flavin monooxygenases controls the
RT formation of floral organs and vascular tissues in Arabidopsis.";
RL Genes Dev. 20:1790-1799(2006).
RN [8]
RP GENE FAMILY.
RC STRAIN=cv. Columbia;
RX PubMed=17461789; DOI=10.1111/j.1365-313x.2007.03101.x;
RA Hansen B.G., Kliebenstein D.J., Halkier B.A.;
RT "Identification of a flavin-monooxygenase as the S-oxygenating enzyme in
RT aliphatic glucosinolate biosynthesis in Arabidopsis.";
RL Plant J. 50:902-910(2007).
RN [9]
RP FUNCTION.
RX PubMed=22025721; DOI=10.1073/pnas.1108436108;
RA Won C., Shen X., Mashiguchi K., Zheng Z., Dai X., Cheng Y., Kasahara H.,
RA Kamiya Y., Chory J., Zhao Y.;
RT "Conversion of tryptophan to indole-3-acetic acid by TRYPTOPHAN
RT AMINOTRANSFERASES OF ARABIDOPSIS and YUCCAs in Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:18518-18523(2011).
CC -!- FUNCTION: Involved in auxin biosynthesis. Belongs to the set of
CC redundant YUCCA genes probably responsible for auxin biosynthesis in
CC roots. {ECO:0000269|PubMed:22025721}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + indole-3-pyruvate + NADPH + O2 = (indol-3-yl)acetate +
CC CO2 + H2O + NADP(+); Xref=Rhea:RHEA:34331, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:17640, ChEBI:CHEBI:30854, ChEBI:CHEBI:57783,
CC ChEBI:CHEBI:58349; EC=1.14.13.168;
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC -!- PATHWAY: Plant hormone metabolism; auxin biosynthesis.
CC -!- SIMILARITY: Belongs to the FMO family. {ECO:0000305}.
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DR EMBL; AY057104; AAL23752.1; -; Genomic_DNA.
DR EMBL; AC002376; AAB80641.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE27721.1; -; Genomic_DNA.
DR EMBL; BT011241; AAR92277.1; -; mRNA.
DR EMBL; BT012546; AAS99690.1; -; mRNA.
DR EMBL; AK228766; BAF00666.1; -; mRNA.
DR PIR; G86178; G86178.
DR RefSeq; NP_171955.1; NM_100340.4.
DR AlphaFoldDB; O23024; -.
DR SMR; O23024; -.
DR STRING; 3702.AT1G04610.1; -.
DR PaxDb; O23024; -.
DR PRIDE; O23024; -.
DR ProteomicsDB; 242339; -.
DR EnsemblPlants; AT1G04610.1; AT1G04610.1; AT1G04610.
DR GeneID; 839474; -.
DR Gramene; AT1G04610.1; AT1G04610.1; AT1G04610.
DR KEGG; ath:AT1G04610; -.
DR Araport; AT1G04610; -.
DR TAIR; locus:2197863; AT1G04610.
DR eggNOG; KOG1399; Eukaryota.
DR HOGENOM; CLU_006909_2_0_1; -.
DR InParanoid; O23024; -.
DR OMA; GHIMHAC; -.
DR OrthoDB; 405736at2759; -.
DR PhylomeDB; O23024; -.
DR UniPathway; UPA00151; -.
DR PRO; PR:O23024; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; O23024; baseline and differential.
DR Genevisible; O23024; AT.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IBA:GO_Central.
DR GO; GO:0103075; F:indole-3-pyruvate monooxygenase activity; IEA:UniProtKB-EC.
DR GO; GO:0004497; F:monooxygenase activity; IBA:GO_Central.
DR GO; GO:0004499; F:N,N-dimethylaniline monooxygenase activity; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0009851; P:auxin biosynthetic process; IBA:GO_Central.
DR GO; GO:0009723; P:response to ethylene; IEP:TAIR.
DR Gene3D; 3.50.50.60; -; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR020946; Flavin_mOase-like.
DR Pfam; PF00743; FMO-like; 1.
DR SUPFAM; SSF51905; SSF51905; 2.
PE 2: Evidence at transcript level;
KW Auxin biosynthesis; FAD; Flavoprotein; Monooxygenase; NADP; Oxidoreductase;
KW Reference proteome.
FT CHAIN 1..437
FT /note="Probable indole-3-pyruvate monooxygenase YUCCA3"
FT /id="PRO_0000400070"
FT BINDING 41..46
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000255"
FT BINDING 212..217
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000255"
SQ SEQUENCE 437 AA; 48747 MW; 5507EDCD4B6789C9 CRC64;
MYGNNNKKSI NITSMFQNLI PEGSDIFSRR CIWVNGPVIV GAGPSGLAVA AGLKREGVPF
IILERANCIA SLWQNRTYDR LKLHLPKQFC QLPNYPFPDE FPEYPTKFQF IQYLESYAAN
FDINPKFNET VQSAKYDETF GLWRVKTISN MGQLGSCEFE YICRWIVVAT GENAEKVVPD
FEGLEDFGGD VLHAGDYKSG GRYQGKKVLV VGCGNSGMEV SLDLYNHGAN PSMVVRSAVH
VLPREIFGKS TFELGVTMMK YMPVWLADKT ILFLARIILG NTDKYGLKRP KIGPLELKNK
EGKTPVLDIG ALPKIRSGKI KIVPGIIKFG KGKVELIDGR VLEIDSVILA TGYRSNVPSW
LKDNDFFSDD GIPKNPFPNG WKGEAGLYAV GFTRKGLFGA SLDAMSVAHD IANRWKEESK
QQKKTAAARH RRCISHF
