YUC7_ARATH
ID YUC7_ARATH Reviewed; 431 AA.
AC O49312;
DT 02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Probable indole-3-pyruvate monooxygenase YUCCA7;
DE EC=1.14.13.168;
DE AltName: Full=Flavin-containing monooxygenase YUCCA7;
GN Name=YUC7; Synonyms=YUCCA7; OrderedLocusNames=At2g33230; ORFNames=F25I18.3;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16818609; DOI=10.1101/gad.1415106;
RA Cheng Y., Dai X., Zhao Y.;
RT "Auxin biosynthesis by the YUCCA flavin monooxygenases controls the
RT formation of floral organs and vascular tissues in Arabidopsis.";
RL Genes Dev. 20:1790-1799(2006).
RN [4]
RP GENE FAMILY.
RC STRAIN=cv. Columbia;
RX PubMed=17461789; DOI=10.1111/j.1365-313x.2007.03101.x;
RA Hansen B.G., Kliebenstein D.J., Halkier B.A.;
RT "Identification of a flavin-monooxygenase as the S-oxygenating enzyme in
RT aliphatic glucosinolate biosynthesis in Arabidopsis.";
RL Plant J. 50:902-910(2007).
RN [5]
RP FUNCTION.
RX PubMed=22025721; DOI=10.1073/pnas.1108436108;
RA Won C., Shen X., Mashiguchi K., Zheng Z., Dai X., Cheng Y., Kasahara H.,
RA Kamiya Y., Chory J., Zhao Y.;
RT "Conversion of tryptophan to indole-3-acetic acid by TRYPTOPHAN
RT AMINOTRANSFERASES OF ARABIDOPSIS and YUCCAs in Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:18518-18523(2011).
RN [6]
RP FUNCTION, TISSUE SPECIFICITY, INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=22109847; DOI=10.1007/s00425-011-1552-3;
RA Lee M., Jung J.H., Han D.Y., Seo P.J., Park W.J., Park C.M.;
RT "Activation of a flavin monooxygenase gene YUCCA7 enhances drought
RT resistance in Arabidopsis.";
RL Planta 235:923-938(2012).
CC -!- FUNCTION: Involved in auxin biosynthesis. Belongs to the set of
CC redundant YUCCA genes probably responsible for auxin biosynthesis in
CC roots. {ECO:0000269|PubMed:22025721, ECO:0000269|PubMed:22109847}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + indole-3-pyruvate + NADPH + O2 = (indol-3-yl)acetate +
CC CO2 + H2O + NADP(+); Xref=Rhea:RHEA:34331, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:17640, ChEBI:CHEBI:30854, ChEBI:CHEBI:57783,
CC ChEBI:CHEBI:58349; EC=1.14.13.168;
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC -!- PATHWAY: Plant hormone metabolism; auxin biosynthesis.
CC -!- TISSUE SPECIFICITY: Expressed in shoot apex regions and siliques, and
CC at high levels in roots. Detected in flowers, stems and leaves.
CC {ECO:0000269|PubMed:22109847}.
CC -!- INDUCTION: Up-regulated by drought and by abscisic acid.
CC {ECO:0000269|PubMed:22109847}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype, due to the redundancy with
CC the other members of the YUCCA family. {ECO:0000269|PubMed:22109847}.
CC -!- SIMILARITY: Belongs to the FMO family. {ECO:0000305}.
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DR EMBL; AC002334; AAC04900.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC08802.1; -; Genomic_DNA.
DR PIR; H84742; H84742.
DR RefSeq; NP_180881.1; NM_128882.2.
DR AlphaFoldDB; O49312; -.
DR SMR; O49312; -.
DR STRING; 3702.AT2G33230.1; -.
DR PaxDb; O49312; -.
DR PRIDE; O49312; -.
DR EnsemblPlants; AT2G33230.1; AT2G33230.1; AT2G33230.
DR GeneID; 817885; -.
DR Gramene; AT2G33230.1; AT2G33230.1; AT2G33230.
DR KEGG; ath:AT2G33230; -.
DR Araport; AT2G33230; -.
DR TAIR; locus:2046545; AT2G33230.
DR eggNOG; KOG1399; Eukaryota.
DR HOGENOM; CLU_006909_2_0_1; -.
DR InParanoid; O49312; -.
DR OMA; ANAWKEE; -.
DR OrthoDB; 405736at2759; -.
DR PhylomeDB; O49312; -.
DR UniPathway; UPA00151; -.
DR PRO; PR:O49312; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O49312; baseline and differential.
DR Genevisible; O49312; AT.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IBA:GO_Central.
DR GO; GO:0103075; F:indole-3-pyruvate monooxygenase activity; IEA:UniProtKB-EC.
DR GO; GO:0004497; F:monooxygenase activity; IBA:GO_Central.
DR GO; GO:0004499; F:N,N-dimethylaniline monooxygenase activity; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0009851; P:auxin biosynthetic process; IBA:GO_Central.
DR GO; GO:0009684; P:indoleacetic acid biosynthetic process; IMP:TAIR.
DR GO; GO:0009414; P:response to water deprivation; IMP:TAIR.
DR Gene3D; 3.50.50.60; -; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR020946; Flavin_mOase-like.
DR Pfam; PF00743; FMO-like; 1.
DR SUPFAM; SSF51905; SSF51905; 2.
PE 2: Evidence at transcript level;
KW Auxin biosynthesis; FAD; Flavoprotein; Monooxygenase; NADP; Oxidoreductase;
KW Reference proteome.
FT CHAIN 1..431
FT /note="Probable indole-3-pyruvate monooxygenase YUCCA7"
FT /id="PRO_0000400074"
FT BINDING 36..41
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000255"
FT BINDING 207..212
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000255"
SQ SEQUENCE 431 AA; 48148 MW; 9CDD6534AE9A0441 CRC64;
MCNNNNTSCV NISSMLQPED IFSRRCIWVN GPVIVGAGPS GLAVAADLKR QEVPFVILER
ANCIASLWQN RTYDRLKLHL PKQFCQLPNL PFPEDIPEYP TKYQFIEYLE SYATHFDLRP
KFNETVQSAK YDKRFGLWRV QTVLRSELLG YCEFEYICRW LVVATGENAE KVVPEFEGLE
DFGGDVLHAG DYKSGERYRG KRVLVVGCGN SGMEVSLDLC NHDASPSMVV RSSVHVLPRE
VLGKSTFELS VTMMKWMPVW LVDKTLLVLT RLLLGNTDKY GLKRPEIGPL ELKNTAGKTP
VLDIGAISMI KSGKIKIVAG IAKFGPGKVE LVDGRVLQID SVILATGYRS NVPSWLKEND
LGEIGIEKNP FPKGWKGKAG LYAVGFTGRG LSGASFDAMS VAHDIANSWK EETKQQIKTV
ATRHRRCISH F
