YUEB_BACSU
ID YUEB_BACSU Reviewed; 1076 AA.
AC O32101;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=ESX secretion system protein YueB {ECO:0000305};
DE AltName: Full=Bacteriophage SPP1 adsorption protein YueB {ECO:0000305};
DE AltName: Full=Bacteriophage SPP1 receptor protein YueB {ECO:0000305};
GN Name=yueB; OrderedLocusNames=BSU31860;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [2]
RP FUNCTION AS A RECEPTOR FOR SPP1.
RX PubMed=15576783; DOI=10.1128/jb.186.24.8337-8346.2004;
RA Sao-Jose C., Baptista C., Santos M.A.;
RT "Bacillus subtilis operon encoding a membrane receptor for bacteriophage
RT SPP1.";
RL J. Bacteriol. 186:8337-8346(2004).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=168, and ATCC 6051;
RX PubMed=23861817; DOI=10.1371/journal.pone.0067840;
RA Baptista C., Barreto H.C., Sao-Jose C.;
RT "High levels of DegU-P activate an Esat-6-like secretion system in Bacillus
RT subtilis.";
RL PLoS ONE 8:E67840-E67840(2013).
RN [4]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=168 / PY79;
RX PubMed=24798022; DOI=10.1371/journal.pone.0096267;
RA Huppert L.A., Ramsdell T.L., Chase M.R., Sarracino D.A., Fortune S.M.,
RA Burton B.M.;
RT "The ESX system in Bacillus subtilis mediates protein secretion.";
RL PLoS ONE 9:E96267-E96267(2014).
CC -!- FUNCTION: Required for YukE secretion. Probable component or regulator
CC of the ESX/ESAT-6-like secretion system (BsEss) (PubMed:23861817,
CC PubMed:24798022). Bacteriophage SPP1 receptor. Essential for the
CC irreversible adsorption of the bacteriophage (PubMed:15576783).
CC {ECO:0000269|PubMed:15576783, ECO:0000269|PubMed:23861817,
CC ECO:0000269|PubMed:24798022}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Cells lacking this gene are blocked in YukE
CC secretion. {ECO:0000269|PubMed:23861817, ECO:0000269|PubMed:24798022}.
CC -!- SIMILARITY: Belongs to the EsaA family. {ECO:0000305}.
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DR EMBL; AL009126; CAB15174.1; -; Genomic_DNA.
DR PIR; C70007; C70007.
DR RefSeq; NP_391064.1; NC_000964.3.
DR RefSeq; WP_003244105.1; NZ_JNCM01000033.1.
DR AlphaFoldDB; O32101; -.
DR IntAct; O32101; 22.
DR STRING; 224308.BSU31860; -.
DR PaxDb; O32101; -.
DR PRIDE; O32101; -.
DR EnsemblBacteria; CAB15174; CAB15174; BSU_31860.
DR GeneID; 936567; -.
DR KEGG; bsu:BSU31860; -.
DR PATRIC; fig|224308.179.peg.3452; -.
DR eggNOG; COG1511; Bacteria.
DR OMA; MYNFYKP; -.
DR BioCyc; BSUB:BSU31860-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR InterPro; IPR023838; T7SS_EsaA.
DR TIGRFAMs; TIGR03929; T7_esaA_Nterm; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Coiled coil; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..1076
FT /note="ESX secretion system protein YueB"
FT /id="PRO_0000066542"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 904..924
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 938..958
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 964..984
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 995..1015
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1040..1060
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 372..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 552..622
FT /evidence="ECO:0000255"
FT COMPBIAS 423..444
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..543
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1076 AA; 119982 MW; CC1A368DF673A53C CRC64;
MTEQRKSLIK LISAVIIILL LPVLFFRFIG DDPTKKAVNS TRQIAVVNED TGVLSDEVKS
DEEDKSAQFG KEVAAVLGER PDYSWTVVNR SAAETGLASK KYDAIVYIPS DFSKNILSYD
KDHPQKATLE FSIQDNLNAV NKEKVQRELE DAQKTMNKKM SALYWNFVSQ KVDNIRGEFD
KIVNKESEFQ NVMYNFYKPS SNDLAGEIKQ QKDLIDELKK SMNEAQGTTK EKASTAEEAK
NTLKEFIDTV ERYKEYQENQ KKLLLAAQDS TQQQIRTGLD AIQAQQKANQ FSERMSGLAT
GIGQAKTQIG LTNLALNNAE KLRQNQVPLQ EMGMKKIEND MFNAFLSRYK SQYEAIKYQN
LNQLQENIGK NRLSLLKPKE SDEKEDGEDT SDNKDDTDKE DIEDIKLDLE KQRDELKNVA
TEIKDISEGL KEPEQEKPTT PDAEEPSTDD SPNTEEPSND IPTSDDQPTN EDTGSSEEGT
QDNGSQNDVQ TNIETGQKHQ ESSKNVPEQD TNTENTGTSK TDFSLIELAD ENDGSNQSDG
LQGDGADGET DISGAKKRLN EAAIKLEEIE NALQEKQEEH NNKLEKHIDE LNQEIKELNK
TVSKLNDQIG DLTKKLVDFD NNVNDAYRLI YNLEDEIIQT LQSRGYIDQK EKLSSIFSSR
IETDNISNLM KYYNSLNLYK STLNDNLDLG SLTIIKGEVI QEQDGNVQSV LALTPEESAS
WEALKNNTMQ TDEDINSFID GMTKFADDYS GYIRDSQAGV LDELTKISES AAKASEQLVT
GATQESATFS NDGLSGTMAL SVQDTVGQEV LQMSDMMGSL SDRQSGIIDY TTNMQQSVND
VQAKADTLNN NWGKNVASTK LVRNDVYGIL GNTLVDGQNN GYVYDYLANP LKISGEVPEE
KIQTVPPVVI LVIVLISSLL IGYFSSYYQN APLLVKGALF GILNILVGLM ISLFGLNIYS
LPDDQTIKWS VFTILLLVAS SAFIRTAFRF GSIPGWVASA AMILFYVAPL IDLIMPNFTF
EDPVSKVYID IQYGTGHLFT MGITVLLIIT VIAVALPLII RLMAEHTAES DETYEA
