ID   YUGJ_BACSU              Reviewed;         387 AA.
AC   O05239;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Probable NADH-dependent butanol dehydrogenase 1;
DE            EC=1.1.1.-;
GN   Name=yugJ; OrderedLocusNames=BSU31370;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9274030; DOI=10.1099/00221287-143-8-2769;
RA   Oudega B., Koningstein G., Rodrigues L., de Sales Ramon M., Hilbert H.,
RA   Duesterhoeft A., Pohl T.M., Weitzenegger T.;
RT   "Analysis of the Bacillus subtilis genome: cloning and nucleotide sequence
RT   of a 62 kb region between 275 degrees (rrnB) and 284 degrees (pai).";
RL   Microbiology 143:2769-2774(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
CC   -!- PATHWAY: Alcohol metabolism; butanol biosynthesis.
CC   -!- SIMILARITY: Belongs to the iron-containing alcohol dehydrogenase
CC       family. {ECO:0000305}.
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DR   EMBL; Z93934; CAB07922.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB15126.1; -; Genomic_DNA.
DR   PIR; A70011; A70011.
DR   RefSeq; NP_391015.1; NC_000964.3.
DR   RefSeq; WP_003228869.1; NZ_JNCM01000033.1.
DR   AlphaFoldDB; O05239; -.
DR   SMR; O05239; -.
DR   IntAct; O05239; 1.
DR   MINT; O05239; -.
DR   STRING; 224308.BSU31370; -.
DR   jPOST; O05239; -.
DR   PaxDb; O05239; -.
DR   PRIDE; O05239; -.
DR   EnsemblBacteria; CAB15126; CAB15126; BSU_31370.
DR   GeneID; 937164; -.
DR   KEGG; bsu:BSU31370; -.
DR   PATRIC; fig|224308.179.peg.3401; -.
DR   eggNOG; COG1979; Bacteria.
DR   InParanoid; O05239; -.
DR   OMA; CTMALNG; -.
DR   PhylomeDB; O05239; -.
DR   BioCyc; BSUB:BSU31370-MON; -.
DR   UniPathway; UPA00743; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0008106; F:alcohol dehydrogenase (NADP+) activity; IBA:GO_Central.
DR   GO; GO:0018455; F:alcohol dehydrogenase [NAD(P)+] activity; IBA:GO_Central.
DR   GO; GO:1990362; F:butanol dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:1990002; F:methylglyoxal reductase (NADPH-dependent, acetol producing); IBA:GO_Central.
DR   GO; GO:0071271; P:1-butanol biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd08187; BDH; 1.
DR   InterPro; IPR001670; ADH_Fe/GldA.
DR   InterPro; IPR018211; ADH_Fe_CS.
DR   InterPro; IPR044731; BDH-like.
DR   PANTHER; PTHR43633; PTHR43633; 1.
DR   Pfam; PF00465; Fe-ADH; 1.
DR   PROSITE; PS00913; ADH_IRON_1; 1.
DR   PROSITE; PS00060; ADH_IRON_2; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase; Reference proteome.
FT   CHAIN           1..387
FT                   /note="Probable NADH-dependent butanol dehydrogenase 1"
FT                   /id="PRO_0000087819"
SQ   SEQUENCE   387 AA;  42733 MW;  65C4EFE35C48DBFA CRC64;
     MQNFTYWNPT KLIFGRGEVE RLPEELKPYG KNVLLVYGGG SIKRSGLYDQ VIEQLNKAGA
     TVHELAGVEP NPRVSTVNKG VAICKEQNID FLLAVGGGSV IDCTKAIAAG AKYDGDAWDI
     VTKKHQPKDA LPFGTVLTLA ATGSEMNSGS VITNWETKEK YGWGSPLVFP KFSILDPVNT
     FTVPKNHTIY GMVDMMSHVF EQYFHHVSNT PYQDRMCESL LRTVIETAPK LINDLENYEL
     RETILYTGTI ALNGMLSMGA RGDWATHNIE HAVSAVYDIP HAGGLAILFP NWMRHTLSEN
     PARMKQLAVR VFDVEEAGKT DEEIALEGID KLSAFWTSLG APNRLADYDI NDEQLDTIAD
     KAMANGTFGQ FKSLNKEDVL SILKASL