YUKD_BACSU
ID YUKD_BACSU Reviewed; 79 AA.
AC P71071; Q795L3;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=ESX secretion system protein YukD {ECO:0000305};
GN Name=yukD; OrderedLocusNames=BSU31900;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9168598; DOI=10.1099/00221287-143-5-1489;
RA Oudega B., Vandenbol M., Koningstein G.;
RT "A 12kb nucleotide sequence containing the alanine dehydrogenase gene at
RT 279 degree on the Bacillus subtilis chromosome.";
RL Microbiology 143:1489-1491(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP DISRUPTION PHENOTYPE.
RC STRAIN=168;
RX PubMed=15576783; DOI=10.1128/jb.186.24.8337-8346.2004;
RA Sao-Jose C., Baptista C., Santos M.A.;
RT "Bacillus subtilis operon encoding a membrane receptor for bacteriophage
RT SPP1.";
RL J. Bacteriol. 186:8337-8346(2004).
RN [4]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=168, and ATCC 6051;
RX PubMed=23861817; DOI=10.1371/journal.pone.0067840;
RA Baptista C., Barreto H.C., Sao-Jose C.;
RT "High levels of DegU-P activate an Esat-6-like secretion system in Bacillus
RT subtilis.";
RL PLoS ONE 8:E67840-E67840(2013).
RN [5]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=168 / PY79;
RX PubMed=24798022; DOI=10.1371/journal.pone.0096267;
RA Huppert L.A., Ramsdell T.L., Chase M.R., Sarracino D.A., Fortune S.M.,
RA Burton B.M.;
RT "The ESX system in Bacillus subtilis mediates protein secretion.";
RL PLoS ONE 9:E96267-E96267(2014).
RN [6]
RP X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 2-79.
RC STRAIN=168;
RX PubMed=15978580; DOI=10.1016/j.febslet.2005.06.002;
RA van den Ent F., Loewe J.;
RT "Crystal structure of the ubiquitin-like protein YukD from Bacillus
RT subtilis.";
RL FEBS Lett. 579:3837-3841(2005).
CC -!- FUNCTION: Required for YukE secretion. Probable component or regulator
CC of the ESX/ESAT-6-like secretion system (BsEss).
CC {ECO:0000269|PubMed:23861817, ECO:0000269|PubMed:24798022}.
CC -!- DISRUPTION PHENOTYPE: Cells lacking this gene are blocked in YukE
CC secretion (PubMed:23861817, PubMed:24798022). They display an increased
CC bacteriophage SPP1 resistance phenotype (PubMed:15576783).
CC {ECO:0000269|PubMed:15576783, ECO:0000269|PubMed:23861817,
CC ECO:0000269|PubMed:24798022}.
CC -!- SIMILARITY: Belongs to the EsaB family. {ECO:0000305}.
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DR EMBL; Z82015; CAB04772.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB15178.1; -; Genomic_DNA.
DR PIR; F70013; F70013.
DR RefSeq; NP_391068.1; NC_000964.3.
DR RefSeq; WP_003228763.1; NZ_JNCM01000033.1.
DR PDB; 2BPS; X-ray; 2.70 A; A/B=2-79.
DR PDBsum; 2BPS; -.
DR AlphaFoldDB; P71071; -.
DR SMR; P71071; -.
DR STRING; 224308.BSU31900; -.
DR PaxDb; P71071; -.
DR EnsemblBacteria; CAB15178; CAB15178; BSU_31900.
DR GeneID; 936543; -.
DR KEGG; bsu:BSU31900; -.
DR PATRIC; fig|224308.179.peg.3455; -.
DR eggNOG; COG5417; Bacteria.
DR OMA; REGYWIR; -.
DR BioCyc; BSUB:BSU31900-MON; -.
DR EvolutionaryTrace; P71071; -.
DR Proteomes; UP000001570; Chromosome.
DR InterPro; IPR014921; EsaB.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR024962; YukD-like.
DR Pfam; PF08817; YukD; 1.
DR PIRSF; PIRSF037793; DUF_ubiquitin-like_YukD; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome.
FT CHAIN 1..79
FT /note="ESX secretion system protein YukD"
FT /id="PRO_0000360174"
FT STRAND 2..8
FT /evidence="ECO:0007829|PDB:2BPS"
FT TURN 10..13
FT /evidence="ECO:0007829|PDB:2BPS"
FT STRAND 16..22
FT /evidence="ECO:0007829|PDB:2BPS"
FT HELIX 29..37
FT /evidence="ECO:0007829|PDB:2BPS"
FT STRAND 49..52
FT /evidence="ECO:0007829|PDB:2BPS"
FT HELIX 53..55
FT /evidence="ECO:0007829|PDB:2BPS"
FT STRAND 57..60
FT /evidence="ECO:0007829|PDB:2BPS"
FT HELIX 66..68
FT /evidence="ECO:0007829|PDB:2BPS"
FT STRAND 75..78
FT /evidence="ECO:0007829|PDB:2BPS"
SQ SEQUENCE 79 AA; 9076 MW; 078982681BFD4685 CRC64;
MYIDITIDLK HYNGSVFDLR LSDYHPVKKV IDIAWQAQSV SMPPREGHWI RVVNKDKVFS
GECKLSDCGI TNGDRLEIL
