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YUKE_BACSU
ID   YUKE_BACSU              Reviewed;          97 AA.
AC   C0SP85; P71072; Q795L2;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Protein YukE {ECO:0000305};
GN   Name=yukE; OrderedLocusNames=BSU31910;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9168598; DOI=10.1099/00221287-143-5-1489;
RA   Oudega B., Vandenbol M., Koningstein G.;
RT   "A 12kb nucleotide sequence containing the alanine dehydrogenase gene at
RT   279 degree on the Bacillus subtilis chromosome.";
RL   Microbiology 143:1489-1491(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   SEQUENCE REVISION.
RX   PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA   Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA   Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT   "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT   168 reference genome a decade later.";
RL   Microbiology 155:1758-1775(2009).
RN   [4]
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=168;
RX   PubMed=15576783; DOI=10.1128/jb.186.24.8337-8346.2004;
RA   Sao-Jose C., Baptista C., Santos M.A.;
RT   "Bacillus subtilis operon encoding a membrane receptor for bacteriophage
RT   SPP1.";
RL   J. Bacteriol. 186:8337-8346(2004).
RN   [5]
RP   SUBUNIT, SUBCELLULAR LOCATION, AND INDUCTION.
RC   STRAIN=ATCC 6051;
RX   PubMed=23861817; DOI=10.1371/journal.pone.0067840;
RA   Baptista C., Barreto H.C., Sao-Jose C.;
RT   "High levels of DegU-P activate an Esat-6-like secretion system in Bacillus
RT   subtilis.";
RL   PLoS ONE 8:E67840-E67840(2013).
RN   [6]
RP   SUBCELLULAR LOCATION.
RC   STRAIN=168 / PY79;
RX   PubMed=24798022; DOI=10.1371/journal.pone.0096267;
RA   Huppert L.A., Ramsdell T.L., Chase M.R., Sarracino D.A., Fortune S.M.,
RA   Burton B.M.;
RT   "The ESX system in Bacillus subtilis mediates protein secretion.";
RL   PLoS ONE 9:E96267-E96267(2014).
RN   [7]
RP   SUBUNIT, SUBCELLULAR LOCATION, DOMAIN, AND MUTAGENESIS OF TRP-44; GLU-45
RP   AND GLY-46.
RX   PubMed=24828531; DOI=10.1073/pnas.1322200111;
RA   Sysoeva T.A., Zepeda-Rivera M.A., Huppert L.A., Burton B.M.;
RT   "Dimer recognition and secretion by the ESX secretion system in Bacillus
RT   subtilis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 111:7653-7658(2014).
RN   [8]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB
RC   3610 / NRRL NRS-744 / VKM B-501;
RX   PubMed=34280190; DOI=10.1371/journal.pgen.1009682;
RA   Kobayashi K.;
RT   "Diverse LXG toxin and antitoxin systems specifically mediate intraspecies
RT   competition in Bacillus subtilis biofilms.";
RL   PLoS Genet. 17:e1009682-e1009682(2021).
CC   -!- FUNCTION: Required to deliver LXG toxins to target cells.
CC       {ECO:0000269|PubMed:34280190}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:23861817,
CC       ECO:0000269|PubMed:24828531}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23861817,
CC       ECO:0000269|PubMed:24798022, ECO:0000269|PubMed:24828531}.
CC       Note=Secreted via the ESX/ESAT-6-like secretion system (BsEss) / type
CC       VII secretion system (T7SS) (PubMed:23861817, PubMed:24798022). Can be
CC       secreted as a dimer (PubMed:24828531). {ECO:0000269|PubMed:23861817,
CC       ECO:0000269|PubMed:24798022, ECO:0000269|PubMed:24828531}.
CC   -!- INDUCTION: Positively regulated by phosphorylated DegU.
CC       {ECO:0000269|PubMed:23861817}.
CC   -!- DOMAIN: The WXG motif and the C-terminal tail are crucial for
CC       secretion. {ECO:0000269|PubMed:24828531}.
CC   -!- DISRUPTION PHENOTYPE: Cells lacking this gene display an increased
CC       bacteriophage SPP1 resistance phenotype (PubMed:15576783). Loss of
CC       delivery of LXG type toxins to target cells (PubMed:34280190).
CC       {ECO:0000269|PubMed:15576783, ECO:0000269|PubMed:34280190}.
CC   -!- SIMILARITY: Belongs to the WXG100 family. sagEsxA-like subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAB04773.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=CAB04773.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; Z82015; CAB04773.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AL009126; CAB15179.2; -; Genomic_DNA.
DR   PIR; G70013; G70013.
DR   RefSeq; NP_391069.2; NC_000964.3.
DR   RefSeq; WP_003220661.1; NZ_JNCM01000033.1.
DR   AlphaFoldDB; C0SP85; -.
DR   SMR; C0SP85; -.
DR   STRING; 224308.BSU31910; -.
DR   jPOST; C0SP85; -.
DR   PaxDb; C0SP85; -.
DR   PRIDE; C0SP85; -.
DR   EnsemblBacteria; CAB15179; CAB15179; BSU_31910.
DR   GeneID; 50136270; -.
DR   GeneID; 64304936; -.
DR   GeneID; 936578; -.
DR   KEGG; bsu:BSU31910; -.
DR   PATRIC; fig|224308.179.peg.3456; -.
DR   eggNOG; COG4842; Bacteria.
DR   OMA; SDLKGMW; -.
DR   PhylomeDB; C0SP85; -.
DR   BioCyc; BSUB:BSU31910-MON; -.
DR   PRO; PR:C0SP85; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR036689; ESAT-6-like_sf.
DR   InterPro; IPR010310; T7SS_ESAT-6-like.
DR   Pfam; PF06013; WXG100; 1.
DR   SUPFAM; SSF140453; SSF140453; 1.
DR   TIGRFAMs; TIGR03930; WXG100_ESAT6; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Reference proteome; Secreted.
FT   CHAIN           1..97
FT                   /note="Protein YukE"
FT                   /id="PRO_0000383635"
FT   COILED          21..94
FT                   /evidence="ECO:0000255"
FT   MUTAGEN         44
FT                   /note="W->A: Lack of secretion, but does not affect
FT                   dimerization."
FT                   /evidence="ECO:0000269|PubMed:24828531"
FT   MUTAGEN         44
FT                   /note="W->E,G,P,R: Lack of secretion."
FT                   /evidence="ECO:0000269|PubMed:24828531"
FT   MUTAGEN         44
FT                   /note="W->F,Y: Strong decrease in secretion."
FT                   /evidence="ECO:0000269|PubMed:24828531"
FT   MUTAGEN         45
FT                   /note="E->A: Does not affect secretion and dimerization."
FT                   /evidence="ECO:0000269|PubMed:24828531"
FT   MUTAGEN         45
FT                   /note="E->D,K,Q,R: Does not affect secretion."
FT                   /evidence="ECO:0000269|PubMed:24828531"
FT   MUTAGEN         45
FT                   /note="E->G: Strong decrease in secretion."
FT                   /evidence="ECO:0000269|PubMed:24828531"
FT   MUTAGEN         46
FT                   /note="G->A: Lack of secretion, but does not affect
FT                   dimerization."
FT                   /evidence="ECO:0000269|PubMed:24828531"
FT   MUTAGEN         46
FT                   /note="G->P,R: Lack of secretion."
FT                   /evidence="ECO:0000269|PubMed:24828531"
SQ   SEQUENCE   97 AA;  10993 MW;  C36A9624626BA4C3 CRC64;
     MAGLIRVTPE ELRAMAKQYG VESQEVLNQV DRLNRMISDL KSMWEGASSE AFADQYEQLK
     PSFIKMSDLL QDVNQQLDQT ANTLESTDQD IANQIRG
 
 
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