ID   YUKI_YERRU              Reviewed;         216 AA.
AC   O87970;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Acyl-homoserine-lactone synthase;
DE            EC=2.3.1.184;
DE   AltName: Full=Autoinducer synthesis protein YukI;
GN   Name=yukI;
OS   Yersinia ruckeri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=29486;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=1315;
RA   Atkinson S., Throup J.P., Williams P., Stewart G.S.A.B.;
RT   "A hierarchical quorum sensing system in Yersinia pseudotuberculosis is
RT   involved in the regulation of motility and morphology.";
RL   Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the synthesis of an acyl-HSL autoinducer that
CC       binds to YukR and which is involved in the regulation of motility and
CC       morphology.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a fatty acyl-[ACP] + S-adenosyl-L-methionine = an N-acyl-L-
CC         homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine;
CC         Xref=Rhea:RHEA:10096, Rhea:RHEA-COMP:9685, Rhea:RHEA-COMP:14125,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:55474,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:64479, ChEBI:CHEBI:138651;
CC         EC=2.3.1.184;
CC   -!- SIMILARITY: Belongs to the autoinducer synthase family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00533}.
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DR   EMBL; AF079135; AAC28701.1; -; Genomic_DNA.
DR   RefSeq; WP_038245616.1; NZ_VDHI01000002.1.
DR   AlphaFoldDB; O87970; -.
DR   SMR; O87970; -.
DR   STRING; 29486.NJ56_07205; -.
DR   GeneID; 66879219; -.
DR   eggNOG; COG3916; Bacteria.
DR   OMA; THIYTIV; -.
DR   OrthoDB; 1725271at2; -.
DR   GO; GO:0061579; F:N-acyl homoserine lactone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-KW.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR018311; Autoind_synth_CS.
DR   InterPro; IPR001690; Autoind_synthase.
DR   PANTHER; PTHR39322; PTHR39322; 1.
DR   Pfam; PF00765; Autoind_synth; 1.
DR   PRINTS; PR01549; AUTOINDCRSYN.
DR   SUPFAM; SSF55729; SSF55729; 1.
DR   PROSITE; PS00949; AUTOINDUCER_SYNTH_1; 1.
DR   PROSITE; PS51187; AUTOINDUCER_SYNTH_2; 1.
PE   3: Inferred from homology;
KW   Autoinducer synthesis; Quorum sensing; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..216
FT                   /note="Acyl-homoserine-lactone synthase"
FT                   /id="PRO_0000210903"
SQ   SEQUENCE   216 AA;  25244 MW;  88DA934709FB40DA CRC64;
     MLEIFDVSYE ELMDMRSDDL YRLRKKTFKD RLQWAVNCSN DMEFDEYDNP NTRYLLGIYG
     NQLICSVRFI ELHRPNMITH TFNAQFDDII LPEGNYIESS RFFVDKSGAK TLLGNRYPIS
     YVLFLAVINY TRHHKHTGIY TIVSRAMLTI LKRSGWQFDV IKEAFVSEKE RIYLLRLPVD
     KHNQALLASQ VNQVLQGSDS ALLAWPISLP VIPELV