CC033_MOUSE
ID CC033_MOUSE Reviewed; 294 AA.
AC Q8BN57; Q059W9;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Protein C3orf33 homolog;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in transcription regulation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK087526; BAC39912.1; -; mRNA.
DR EMBL; BC125500; AAI25501.1; -; mRNA.
DR EMBL; BC132160; AAI32161.1; -; mRNA.
DR CCDS; CCDS38445.1; -.
DR RefSeq; NP_808524.1; NM_177856.4.
DR AlphaFoldDB; Q8BN57; -.
DR iPTMnet; Q8BN57; -.
DR PhosphoSitePlus; Q8BN57; -.
DR EPD; Q8BN57; -.
DR MaxQB; Q8BN57; -.
DR PaxDb; Q8BN57; -.
DR PeptideAtlas; Q8BN57; -.
DR PRIDE; Q8BN57; -.
DR Antibodypedia; 46752; 54 antibodies from 12 providers.
DR Ensembl; ENSMUST00000061706; ENSMUSP00000058114; ENSMUSG00000048581.
DR GeneID; 329659; -.
DR KEGG; mmu:329659; -.
DR UCSC; uc008pkb.1; mouse.
DR MGI; MGI:3607716; E130311K13Rik.
DR VEuPathDB; HostDB:ENSMUSG00000048581; -.
DR eggNOG; ENOG502QR9T; Eukaryota.
DR GeneTree; ENSGT00390000004493; -.
DR HOGENOM; CLU_069834_0_0_1; -.
DR InParanoid; Q8BN57; -.
DR OMA; YWRIHRN; -.
DR OrthoDB; 1030642at2759; -.
DR PhylomeDB; Q8BN57; -.
DR TreeFam; TF313180; -.
DR BioGRID-ORCS; 329659; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q8BN57; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q8BN57; protein.
DR Bgee; ENSMUSG00000048581; Expressed in interventricular septum and 222 other tissues.
DR Genevisible; Q8BN57; MM.
DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.
DR GO; GO:0051090; P:regulation of DNA-binding transcription factor activity; ISS:UniProtKB.
DR Gene3D; 2.40.50.90; -; 1.
DR InterPro; IPR042421; C3orf33-like.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR PANTHER; PTHR28434; PTHR28434; 1.
DR SUPFAM; SSF50199; SSF50199; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q6P1S2"
FT CHAIN 2..294
FT /note="Protein C3orf33 homolog"
FT /id="PRO_0000254578"
FT TRANSMEM 36..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 244..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..268
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q6P1S2"
SQ SEQUENCE 294 AA; 33668 MW; DD394690EDCDF1C4 CRC64;
MARPPASLGS QAPDRDRGEA NVVTRVSQWA DNHLRLVQNI STGMAIAGIM LLIRSVRLTS
KFTTSSDIPV EFIRKKVKLR GRLQRITECG LEIEHIPITL PFISSWKEEP RGVLLVKLAG
VELTESGKVW LQAELKPSQL LWFQLLGKED SALFCYLLVN KGGYFNVNLN EEILRRGLGK
TVLVKGLNYD SKTHWKIHRN LLKAELTALK KGEGIWKEES EKESYFRKLK DSWRERWTKD
NDLKPAGADL GSTKDSYHDS RRRASGKGKD SVSNYSFFLK LREFVSRLHF WRKG
