YUSV_BACSU
ID YUSV_BACSU Reviewed; 275 AA.
AC O32188;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Probable siderophore transport system ATP-binding protein YusV;
GN Name=yusV; OrderedLocusNames=BSU32940;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [2]
RP INDUCTION.
RC STRAIN=168;
RX PubMed=12354229; DOI=10.1046/j.1365-2958.2002.03113.x;
RA Baichoo N., Wang T., Ye R., Helmann J.D.;
RT "Global analysis of the Bacillus subtilis Fur regulon and the iron
RT starvation stimulon.";
RL Mol. Microbiol. 45:1613-1629(2002).
RN [3]
RP FUNCTION, POSSIBLE SUBUNIT, DISRUPTION PHENOTYPE, AND INDUCTION.
RC STRAIN=168;
RX PubMed=16672620; DOI=10.1128/jb.188.10.3664-3673.2006;
RA Ollinger J., Song K.-B., Antelmann H., Hecker M., Helmann J.D.;
RT "Role of the Fur regulon in iron transport in Bacillus subtilis.";
RL J. Bacteriol. 188:3664-3673(2006).
CC -!- FUNCTION: Provides the ATPase subunit for at least 2 ABC transporter
CC complexes; YfiYZ/YfhA/YusV involved in import of the iron-hydroxamate
CC siderophores schizokinen, arthrobactin and corprogen (Probable), and
CC FeuABC/YusV involved in import of the catecholate siderophores
CC bacillibactin and enterobactin (Probable). Probably responsible for
CC energy coupling to the transport system (By similarity). {ECO:0000250,
CC ECO:0000269|PubMed:16672620, ECO:0000305}.
CC -!- SUBUNIT: The iron-hydroxamate siderophore complex is composed of one
CC ATP-binding protein (YusV), two transmembrane proteins (YfiZ and YfhA)
CC and a solute-binding protein (YfiY); the catechoplate siderophore
CC complex is composed of one ATP-binding protein (YusV), two
CC transmembrane proteins (FeuB and FeuC) and a solute-binding protein
CC (FeuA). {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Peripheral membrane
CC protein {ECO:0000305}.
CC -!- INDUCTION: Induced by iron starvation, partially repressed by fur.
CC {ECO:0000269|PubMed:12354229, ECO:0000269|PubMed:16672620}.
CC -!- DISRUPTION PHENOTYPE: Strains lacking this gene show a reduction in
CC growth stimulation by the iron-hydroxamate siderophores schizokinen and
CC arthrobactin compared to wild-type. They also show a reduction in
CC growth stimulation by the catecholate siderophores enterobactin and
CC bacillibactin. {ECO:0000269|PubMed:16672620}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR EMBL; AL009126; CAB15283.1; -; Genomic_DNA.
DR PIR; G70022; G70022.
DR RefSeq; NP_391173.1; NC_000964.3.
DR RefSeq; WP_010886609.1; NZ_JNCM01000033.1.
DR AlphaFoldDB; O32188; -.
DR SMR; O32188; -.
DR STRING; 224308.BSU32940; -.
DR PaxDb; O32188; -.
DR PRIDE; O32188; -.
DR EnsemblBacteria; CAB15283; CAB15283; BSU_32940.
DR GeneID; 935921; -.
DR KEGG; bsu:BSU32940; -.
DR PATRIC; fig|224308.43.peg.3449; -.
DR eggNOG; COG1120; Bacteria.
DR InParanoid; O32188; -.
DR OMA; RCWIAMA; -.
DR PhylomeDB; O32188; -.
DR BioCyc; BSUB:BSU32940-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Cell membrane; Ion transport; Iron; Iron transport; Membrane;
KW Nucleotide-binding; Reference proteome; Transport.
FT CHAIN 1..275
FT /note="Probable siderophore transport system ATP-binding
FT protein YusV"
FT /id="PRO_0000363831"
FT DOMAIN 6..242
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 38..45
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 275 AA; 30494 MW; 4E0D20462523B74C CRC64;
MGMSAISTET LSLGYGDAVI IDELNLTIPK GEITVFIGSN GCGKSTLLRS LARLMKPRGG
SVLLEGRAIA KLPTKEVAKE LAILPQGPSA PEGLTVHQLV KQGRYPYQNW LKQWSKEDEE
AVERALKATK LEDMADRAVD SLSGGQRQRA WIAMTLAQET DIILLDEPTT YLDMTHQIEI
LDLLFELNEK EDRTIVMVLH DLNLACRYAH HLVAIKDKRI YAEGRPEEVI TCDLVQNVFS
MNCQVTQDPL FGTPLCIPHG RGRCIVQEAA FTSHG
