CC038_HUMAN
ID CC038_HUMAN Reviewed; 329 AA.
AC Q5JPI3; B2R8X6; Q8TC85;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Uncharacterized protein C3orf38;
GN Name=C3orf38;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Lymph node;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION.
RX PubMed=17464193;
RA Park K.M., Kang E., Jeon Y.-J., Kim N., Kim N.-S., Yoo H.-S., Yeom Y.I.,
RA Kim S.J.;
RT "Identification of novel regulators of apoptosis using a high-throughput
RT cell-based screen.";
RL Mol. Cells 23:170-174(2007).
RN [5]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2 (ISOFORM 2), CLEAVAGE OF
RP INITIATOR METHIONINE [LARGE SCALE ANALYSIS] (ISOFORM 2), AND IDENTIFICATION
RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- FUNCTION: May be involved in apoptosis regulation.
CC {ECO:0000269|PubMed:17464193}.
CC -!- INTERACTION:
CC Q5JPI3-2; O95429: BAG4; NbExp=4; IntAct=EBI-12009184, EBI-2949658;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5JPI3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5JPI3-2; Sequence=VSP_019621;
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DR EMBL; AK313547; BAG36323.1; -; mRNA.
DR EMBL; AL832398; CAI46184.1; -; mRNA.
DR EMBL; BC024188; AAH24188.1; -; mRNA.
DR CCDS; CCDS2921.2; -. [Q5JPI3-1]
DR RefSeq; NP_776185.2; NM_173824.3. [Q5JPI3-1]
DR AlphaFoldDB; Q5JPI3; -.
DR BioGRID; 130054; 15.
DR IntAct; Q5JPI3; 3.
DR STRING; 9606.ENSP00000322469; -.
DR iPTMnet; Q5JPI3; -.
DR PhosphoSitePlus; Q5JPI3; -.
DR BioMuta; C3orf38; -.
DR DMDM; 74708031; -.
DR EPD; Q5JPI3; -.
DR jPOST; Q5JPI3; -.
DR MassIVE; Q5JPI3; -.
DR MaxQB; Q5JPI3; -.
DR PaxDb; Q5JPI3; -.
DR PeptideAtlas; Q5JPI3; -.
DR PRIDE; Q5JPI3; -.
DR ProteomicsDB; 63017; -. [Q5JPI3-1]
DR ProteomicsDB; 63018; -. [Q5JPI3-2]
DR Antibodypedia; 32056; 62 antibodies from 14 providers.
DR DNASU; 285237; -.
DR Ensembl; ENST00000318887.8; ENSP00000322469.3; ENSG00000179021.10. [Q5JPI3-1]
DR GeneID; 285237; -.
DR KEGG; hsa:285237; -.
DR MANE-Select; ENST00000318887.8; ENSP00000322469.3; NM_173824.4; NP_776185.2.
DR UCSC; uc003dqw.4; human. [Q5JPI3-1]
DR CTD; 285237; -.
DR DisGeNET; 285237; -.
DR GeneCards; C3orf38; -.
DR HGNC; HGNC:28384; C3orf38.
DR HPA; ENSG00000179021; Low tissue specificity.
DR neXtProt; NX_Q5JPI3; -.
DR OpenTargets; ENSG00000179021; -.
DR PharmGKB; PA142672399; -.
DR VEuPathDB; HostDB:ENSG00000179021; -.
DR eggNOG; ENOG502RKN5; Eukaryota.
DR GeneTree; ENSGT00390000000367; -.
DR HOGENOM; CLU_060119_0_0_1; -.
DR InParanoid; Q5JPI3; -.
DR OMA; CGTNEVR; -.
DR OrthoDB; 1399225at2759; -.
DR PhylomeDB; Q5JPI3; -.
DR TreeFam; TF323327; -.
DR PathwayCommons; Q5JPI3; -.
DR SignaLink; Q5JPI3; -.
DR BioGRID-ORCS; 285237; 173 hits in 1061 CRISPR screens.
DR ChiTaRS; C3orf38; human.
DR GenomeRNAi; 285237; -.
DR Pharos; Q5JPI3; Tdark.
DR PRO; PR:Q5JPI3; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q5JPI3; protein.
DR Bgee; ENSG00000179021; Expressed in secondary oocyte and 179 other tissues.
DR ExpressionAtlas; Q5JPI3; baseline and differential.
DR Genevisible; Q5JPI3; HS.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB.
DR InterPro; IPR032710; NTF2-like_dom_sf.
DR InterPro; IPR026698; UPF_C3orf38.
DR PANTHER; PTHR21084; PTHR21084; 1.
DR Pfam; PF15008; DUF4518; 1.
DR SUPFAM; SSF54427; SSF54427; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Apoptosis; Reference proteome.
FT CHAIN 1..329
FT /note="Uncharacterized protein C3orf38"
FT /id="PRO_0000244989"
FT VAR_SEQ 1..2
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_019621"
FT INIT_MET Q5JPI3-2:1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:22814378"
FT MOD_RES Q5JPI3-2:2
FT /note="N-acetylserine"
FT /evidence="ECO:0007744|PubMed:22814378"
SQ SEQUENCE 329 AA; 37541 MW; 1D50C818B7F029ED CRC64;
MEMSGLSFSE MEGCRNLLGL LDNDEIMALC DTVTNRLVQP QDRQDAVHAI LAYSQSAEEL
LRRRKVHREV IFKYLATQGI VIPPATEKHN LIQHAKDYWQ KQPQLKLKET PEPVTKTEDI
HLFQQQVKED KKAEKVDFRR LGEEFCHWFF GLLNSQNPFL GPPQDEWGPQ HFWHDVKLRF
YYNTSEQNVM DYHGAEIVSL RLLSLVKEEF LFLSPNLDSH GLKCASSPHG LVMVGVAGTV
HRGNTCLGIF EQIFGLIRCP FVENTWKIKF INLKIMGESS LAPGTLPKPS VKFEQSDLEA
FYNVITVCGT NEVRHNVKQA SDSGTGDQV
