CC062_HUMAN
ID CC062_HUMAN Reviewed; 267 AA.
AC Q6ZUJ4; Q6P7E9; Q7Z3X6;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Uncharacterized protein C3orf62;
GN Name=C3orf62;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Synovial cell;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta, and PNS;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=31930642; DOI=10.1002/mrd.23314;
RA Wu X.L., Yun D.M., Gao S., Liang A.J., Duan Z.Z., Wang H.S., Wang G.S.,
RA Sun F.;
RT "The testis-specific gene 1700102P08Rik is essential for male fertility.";
RL Mol. Reprod. Dev. 87:231-240(2020).
CC -!- FUNCTION: Essential for normal spermatogenesis and male fertility.
CC {ECO:0000250|UniProtKB:Q9D9C7}.
CC -!- INTERACTION:
CC Q6ZUJ4; Q13515: BFSP2; NbExp=3; IntAct=EBI-2837036, EBI-10229433;
CC Q6ZUJ4; Q96CS2: HAUS1; NbExp=4; IntAct=EBI-2837036, EBI-2514791;
CC Q6ZUJ4; Q8WYH8: ING5; NbExp=3; IntAct=EBI-2837036, EBI-488533;
CC Q6ZUJ4; P12035: KRT3; NbExp=3; IntAct=EBI-2837036, EBI-2430095;
CC Q6ZUJ4; Q8IXW0: LMNTD2; NbExp=3; IntAct=EBI-2837036, EBI-12028858;
CC Q6ZUJ4; Q9Y605: MRFAP1; NbExp=3; IntAct=EBI-2837036, EBI-995714;
CC Q6ZUJ4; Q96HT8: MRFAP1L1; NbExp=4; IntAct=EBI-2837036, EBI-748896;
CC Q6ZUJ4; O75679: RFPL3; NbExp=3; IntAct=EBI-2837036, EBI-10188956;
CC Q6ZUJ4; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-2837036, EBI-5235340;
CC Q6ZUJ4; O14530: TXNDC9; NbExp=3; IntAct=EBI-2837036, EBI-707554;
CC -!- TISSUE SPECIFICITY: Testis. Down-regulated in men with spermatocyte
CC arrest. {ECO:0000269|PubMed:31930642}.
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DR EMBL; AK125642; BAC86231.1; -; mRNA.
DR EMBL; BC023586; AAH23586.1; -; mRNA.
DR EMBL; BC053629; AAH53629.2; -; mRNA.
DR EMBL; BC061697; AAH61697.2; -; mRNA.
DR CCDS; CCDS2792.1; -.
DR RefSeq; NP_940964.1; NM_198562.2.
DR AlphaFoldDB; Q6ZUJ4; -.
DR BioGRID; 131974; 19.
DR IntAct; Q6ZUJ4; 33.
DR STRING; 9606.ENSP00000341139; -.
DR PhosphoSitePlus; Q6ZUJ4; -.
DR BioMuta; C3orf62; -.
DR DMDM; 74738329; -.
DR MassIVE; Q6ZUJ4; -.
DR PaxDb; Q6ZUJ4; -.
DR PeptideAtlas; Q6ZUJ4; -.
DR PRIDE; Q6ZUJ4; -.
DR ProteomicsDB; 68333; -.
DR Antibodypedia; 45957; 49 antibodies from 14 providers.
DR DNASU; 375341; -.
DR Ensembl; ENST00000343010.8; ENSP00000341139.3; ENSG00000188315.8.
DR GeneID; 375341; -.
DR KEGG; hsa:375341; -.
DR MANE-Select; ENST00000343010.8; ENSP00000341139.3; NM_198562.3; NP_940964.1.
DR UCSC; uc003cwn.3; human.
DR CTD; 375341; -.
DR DisGeNET; 375341; -.
DR GeneCards; C3orf62; -.
DR HGNC; HGNC:24771; C3orf62.
DR HPA; ENSG00000188315; Low tissue specificity.
DR neXtProt; NX_Q6ZUJ4; -.
DR OpenTargets; ENSG00000188315; -.
DR PharmGKB; PA143485337; -.
DR VEuPathDB; HostDB:ENSG00000188315; -.
DR eggNOG; ENOG502S5U4; Eukaryota.
DR GeneTree; ENSGT00390000000252; -.
DR HOGENOM; CLU_091203_0_0_1; -.
DR InParanoid; Q6ZUJ4; -.
DR OMA; KVDSNMP; -.
DR OrthoDB; 1500649at2759; -.
DR PhylomeDB; Q6ZUJ4; -.
DR TreeFam; TF336411; -.
DR PathwayCommons; Q6ZUJ4; -.
DR SignaLink; Q6ZUJ4; -.
DR BioGRID-ORCS; 375341; 15 hits in 1051 CRISPR screens.
DR ChiTaRS; C3orf62; human.
DR GenomeRNAi; 375341; -.
DR Pharos; Q6ZUJ4; Tdark.
DR PRO; PR:Q6ZUJ4; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q6ZUJ4; protein.
DR Bgee; ENSG00000188315; Expressed in left testis and 114 other tissues.
DR ExpressionAtlas; Q6ZUJ4; baseline and differential.
DR Genevisible; Q6ZUJ4; HS.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR InterPro; IPR031670; DUF4712.
DR PANTHER; PTHR36680; PTHR36680; 1.
DR Pfam; PF15830; DUF4712; 1.
PE 1: Evidence at protein level;
KW Differentiation; Phosphoprotein; Reference proteome; Spermatogenesis.
FT CHAIN 1..267
FT /note="Uncharacterized protein C3orf62"
FT /id="PRO_0000239305"
FT MOD_RES 210
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9D9C7"
FT MOD_RES 224
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9D9C7"
FT VARIANT 110
FT /note="E -> K (in dbSNP:rs13077498)"
FT /id="VAR_050724"
FT CONFLICT 71
FT /note="A -> S (in Ref. 2; AAH61697)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 267 AA; 30194 MW; DE0F03026BA268F0 CRC64;
MHYIKTWSLL GEMSEKLRRC RKELTAAIDR AFEGVSYSQE CTGQQRLELS AAPLSFSLPV
HRLLCRRHPL AACSSAAPFA AVPCAPENEN PAFATNHAPV NAKPHALCPE RKPLTSKENV
LMHSSILAPE RESWRTAGEG ENWRKENLRK DMERDLKADS NMPLNNSSQE VTKDLLDMID
HTSIRTIEEL AGKIEFENEL NHMCGHCQDS PFKEEAWALL MDKSPQKATD ADPGSLKQAF
DDHNIVETVL DLEEDYNVMT SFKYQIE
