CC062_MOUSE
ID CC062_MOUSE Reviewed; 252 AA.
AC Q9D9C7; A0A0R4J0D7; Q6P8V6;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-FEB-2022, sequence version 2.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Uncharacterized protein C3orf62 homolog;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-195 AND SER-209, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP FUNCTION, DISRUPTION PHENOTYPE, AND TISSUE SPECIFICITY.
RX PubMed=31930642; DOI=10.1002/mrd.23314;
RA Wu X.L., Yun D.M., Gao S., Liang A.J., Duan Z.Z., Wang H.S., Wang G.S.,
RA Sun F.;
RT "The testis-specific gene 1700102P08Rik is essential for male fertility.";
RL Mol. Reprod. Dev. 87:231-240(2020).
CC -!- FUNCTION: Essential for normal spermatogenesis and male fertility.
CC {ECO:0000269|PubMed:31930642}.
CC -!- TISSUE SPECIFICITY: Testis-specific. Highly expressed in spermatocytes
CC (at protein level). {ECO:0000269|PubMed:31930642}.
CC -!- DISRUPTION PHENOTYPE: Male mice are infertile with smaller testis and
CC epididymis, but female mice retain normal fertility (PubMed:31930642).
CC Spermatogenesis in the male mouse is arrested at the spermatocyte
CC stage, and no sperm is found in the epididymis (PubMed:31930642). Germ
CC cells apoptosis is increased without changes to the serum concentration
CC of testosterone, LH, and FSH or synapsis and recombination during
CC meiosis (PubMed:31930642). {ECO:0000269|PubMed:31930642}.
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DR EMBL; AK007115; BAB24864.1; -; mRNA.
DR EMBL; GL456151; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC061048; AAH61048.1; -; mRNA.
DR CCDS; CCDS23524.1; -.
DR RefSeq; NP_444446.2; NM_053216.2.
DR AlphaFoldDB; Q9D9C7; -.
DR STRING; 10090.ENSMUSP00000035234; -.
DR iPTMnet; Q9D9C7; -.
DR PhosphoSitePlus; Q9D9C7; -.
DR PaxDb; Q9D9C7; -.
DR PRIDE; Q9D9C7; -.
DR ProteomicsDB; 332943; -.
DR Antibodypedia; 45957; 49 antibodies from 14 providers.
DR DNASU; 112418; -.
DR Ensembl; ENSMUST00000035234; ENSMUSP00000035234; ENSMUSG00000032611.
DR GeneID; 112418; -.
DR KEGG; mmu:112418; -.
DR UCSC; uc009rpk.2; mouse.
DR MGI; MGI:2148248; 1700102P08Rik.
DR VEuPathDB; HostDB:ENSMUSG00000032611; -.
DR eggNOG; ENOG502S5U4; Eukaryota.
DR GeneTree; ENSGT00390000000252; -.
DR InParanoid; Q9D9C7; -.
DR OMA; KVDSNMP; -.
DR OrthoDB; 1500649at2759; -.
DR PhylomeDB; Q9D9C7; -.
DR TreeFam; TF336411; -.
DR BioGRID-ORCS; 112418; 3 hits in 72 CRISPR screens.
DR ChiTaRS; 1700102P08Rik; mouse.
DR PRO; PR:Q9D9C7; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q9D9C7; protein.
DR Bgee; ENSMUSG00000032611; Expressed in spermatocyte and 70 other tissues.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IMP:UniProtKB.
DR InterPro; IPR031670; DUF4712.
DR PANTHER; PTHR36680; PTHR36680; 1.
DR Pfam; PF15830; DUF4712; 1.
PE 1: Evidence at protein level;
KW Differentiation; Phosphoprotein; Reference proteome; Spermatogenesis.
FT CHAIN 1..252
FT /note="Uncharacterized protein C3orf62 homolog"
FT /id="PRO_0000239306"
FT MOD_RES 195
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 209
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 78
FT /note="G -> R (in Ref. 1; BAB24864)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 252 AA; 28436 MW; 8659103D5AA4A3F6 CRC64;
MSEKLRRCRK ELTAAIDRAF EGVRHSQECT AQQRLDAPSL TSQPVHRLLC RNPLAACPSA
APYSGASCAP ESENPAFGTH HIPVNSKLQQ PLYPKRKPLT SKENVLMQSS ILARDRQFWR
AAGDGEDWRK DSLRKDMERD LKADPNVLLS SSSQEVTKDL LDMIDHTSIR TIEELAGKLE
FENELNRVCG HCQDSPFKEE AWALLVDESP QKALDADPGS LKQALDDQNI VETVLDLEED
YNLMTSFKYQ IE
