YVBW_BACSU
ID YVBW_BACSU Reviewed; 447 AA.
AC O32257;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Uncharacterized amino acid permease YvbW;
GN Name=yvbW; OrderedLocusNames=BSU34010;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [2]
RP FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX DOI=10.4236/aim.2014.48053;
RA Rollins S.M.;
RT "Induced transcriptional expression of Bacillus subtilis amino acid
RT permease yvbW in response to leucine limitation.";
RL Adv. Microbiol. 4:484-492(2014).
CC -!- FUNCTION: May participate in leucine metabolism. May transport leucine
CC or a compound related to leucine metabolism. {ECO:0000269|Ref.2}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- INDUCTION: Induced in response to leucine limitation. Regulated via the
CC T box transcriptional antitermination system. {ECO:0000269|Ref.2}.
CC -!- DISRUPTION PHENOTYPE: No growth phenotype is observed for the knockout
CC strain. {ECO:0000269|Ref.2}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. {ECO:0000305}.
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DR EMBL; AL009126; CAB15406.1; -; Genomic_DNA.
DR PIR; G70030; G70030.
DR RefSeq; NP_391281.1; NC_000964.3.
DR RefSeq; WP_003228313.1; NZ_JNCM01000033.1.
DR AlphaFoldDB; O32257; -.
DR SMR; O32257; -.
DR IntAct; O32257; 1.
DR STRING; 224308.BSU34010; -.
DR PaxDb; O32257; -.
DR PRIDE; O32257; -.
DR EnsemblBacteria; CAB15406; CAB15406; BSU_34010.
DR GeneID; 936289; -.
DR KEGG; bsu:BSU34010; -.
DR PATRIC; fig|224308.179.peg.3687; -.
DR eggNOG; COG1113; Bacteria.
DR InParanoid; O32257; -.
DR OMA; SMNSGLY; -.
DR PhylomeDB; O32257; -.
DR BioCyc; BSUB:BSU34010-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015171; F:amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR Pfam; PF00324; AA_permease; 1.
PE 2: Evidence at transcript level;
KW Amino-acid transport; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..447
FT /note="Uncharacterized amino acid permease YvbW"
FT /id="PRO_0000376831"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..311
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 333..353
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 361..381
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 393..415
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 419..441
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 447 AA; 49178 MW; AD6CAFC80AC33805 CRC64;
MKNDNQTLKR TMTSRHIMMM ALGGAIGAGL FKGSSSAIDV AGPSVIIAYL LGGIILLFIM
QGLAEMAVRN RNARTFRDLV QQVLGNYAAY FLDWIYWKMW VLNIAAEAVV AAIFIQYWLP
GCPIWVLALG ISLIVTIVNL LSVKIFAETE YWLAMIKITV IIIFIILGLL LLFVSFGDHT
ASGFSNLTDH GGFFPHGGTG LITAMLVVIY SYGGTEIIGV TLAETKNPEK VVPKAVRSTL
TRIVAFYLLP FFIIVSLIPW NQVNSVPESP FVMVFKMVGI PGADHIMNAV ILLAIISSMN
SGLYGSSRIL YTQASDGRLP KVFSKLSSKN VPMFAILMCT SSLYIGVLIS LFAGSQTFNY
LMGSLGYTVL FIWLIIGFAH LKSRKQQTET PAYYVKWFPY TTWFAIVALL AILIGVIMTT
SIVITGITAA IYLLITVAYL VKGRKHQ
