ID   CC070_HUMAN             Reviewed;         250 AA.
AC   A6NLC5; B2RNY2; B9EH83;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=UPF0524 protein C3orf70;
GN   Name=C3orf70;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA   Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA   Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA   Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA   Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA   Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA   Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA   Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA   Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA   Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA   Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA   Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA   Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA   Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA   Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May play a role in neuronal and neurobehavioral development.
CC       {ECO:0000250|UniProtKB:Q1LY84}.
CC   -!- SIMILARITY: Belongs to the UPF0524 family. {ECO:0000305}.
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DR   EMBL; AC025573; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471052; EAW78232.1; -; Genomic_DNA.
DR   EMBL; BC137178; AAI37179.1; -; mRNA.
DR   EMBL; BC137179; AAI37180.1; -; mRNA.
DR   EMBL; BC150565; AAI50566.1; -; mRNA.
DR   CCDS; CCDS33900.1; -.
DR   RefSeq; NP_001020437.1; NM_001025266.1.
DR   AlphaFoldDB; A6NLC5; -.
DR   BioGRID; 130098; 1.
DR   STRING; 9606.ENSP00000334974; -.
DR   iPTMnet; A6NLC5; -.
DR   PhosphoSitePlus; A6NLC5; -.
DR   BioMuta; C3orf70; -.
DR   jPOST; A6NLC5; -.
DR   MassIVE; A6NLC5; -.
DR   MaxQB; A6NLC5; -.
DR   PaxDb; A6NLC5; -.
DR   PeptideAtlas; A6NLC5; -.
DR   PRIDE; A6NLC5; -.
DR   ProteomicsDB; 1464; -.
DR   Antibodypedia; 52632; 40 antibodies from 11 providers.
DR   DNASU; 285382; -.
DR   Ensembl; ENST00000335012.3; ENSP00000334974.2; ENSG00000187068.3.
DR   GeneID; 285382; -.
DR   KEGG; hsa:285382; -.
DR   MANE-Select; ENST00000335012.3; ENSP00000334974.2; NM_001025266.3; NP_001020437.1.
DR   UCSC; uc003fpd.3; human.
DR   CTD; 285382; -.
DR   DisGeNET; 285382; -.
DR   GeneCards; C3orf70; -.
DR   HGNC; HGNC:33731; C3orf70.
DR   HPA; ENSG00000187068; Tissue enhanced (brain, smooth muscle).
DR   neXtProt; NX_A6NLC5; -.
DR   OpenTargets; ENSG00000187068; -.
DR   PharmGKB; PA162379707; -.
DR   VEuPathDB; HostDB:ENSG00000187068; -.
DR   eggNOG; ENOG502QQSJ; Eukaryota.
DR   GeneTree; ENSGT00390000006618; -.
DR   HOGENOM; CLU_081879_0_0_1; -.
DR   InParanoid; A6NLC5; -.
DR   OMA; GAHKCPK; -.
DR   OrthoDB; 1244564at2759; -.
DR   PhylomeDB; A6NLC5; -.
DR   TreeFam; TF328625; -.
DR   PathwayCommons; A6NLC5; -.
DR   BioGRID-ORCS; 285382; 15 hits in 1045 CRISPR screens.
DR   ChiTaRS; C3orf70; human.
DR   GenomeRNAi; 285382; -.
DR   Pharos; A6NLC5; Tdark.
DR   PRO; PR:A6NLC5; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; A6NLC5; protein.
DR   Bgee; ENSG00000187068; Expressed in saphenous vein and 176 other tissues.
DR   Genevisible; A6NLC5; HS.
DR   GO; GO:0048512; P:circadian behavior; ISS:UniProtKB.
DR   GO; GO:0007399; P:nervous system development; ISS:UniProtKB.
DR   InterPro; IPR029670; UPF0524_fam.
DR   PANTHER; PTHR31785; PTHR31785; 1.
DR   Pfam; PF15823; UPF0524; 1.
PE   2: Evidence at transcript level;
KW   Neurogenesis; Reference proteome.
FT   CHAIN           1..250
FT                   /note="UPF0524 protein C3orf70"
FT                   /id="PRO_0000319976"
FT   REGION          201..250
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        205..224
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        227..250
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   250 AA;  27769 MW;  5B2930FDE8905AC3 CRC64;
     MSAAASPASE RGWKSEKLDE AQALARSCAA RRPDFQPCDG LSICATHSHG KCFKLHWCCH
     LGWCHCKYMY QPMTPVEQLP STEIPARPRE PTNTIQISVS LTEHFLKFAS VFQPPLPPDS
     PRYCMISDLF IDNYQVKCIN GKMCYVQKQP APHSHRMSPE EVSAHDALIS KESNTPKIDH
     CSSPSSSEDS GINAIGAHYV ESCDEDTEEG AELSSEEDYS PESSWEPDEC TLLSPSQSDL
     EVIETIETTV