YVCA_BACSU
ID YVCA_BACSU Reviewed; 241 AA.
AC O06965; Q795F4; Q798I4;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 2.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Putative lipoprotein YvcA;
DE Flags: Precursor;
GN Name=yvcA; Synonyms=yvrA; OrderedLocusNames=BSU34850;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Lazarevic V., Soldo B., Rivolta C., Reynolds S., Mauel C., Karamata D.;
RT "Nucleotide sequence of the 300-304 chromosomal segment of Bacillus
RT subtilis.";
RL Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 178-241.
RC STRAIN=168;
RA Denizot F.;
RL Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION, INDUCTION BY DEGU, AND DISRUPTION PHENOTYPE.
RX PubMed=17590234; DOI=10.1111/j.1365-2958.2007.05810.x;
RA Verhamme D.T., Kiley T.B., Stanley-Wall N.R.;
RT "DegU co-ordinates multicellular behaviour exhibited by Bacillus
RT subtilis.";
RL Mol. Microbiol. 65:554-568(2007).
RN [5]
RP TRANSCRIPTION REGULATION.
RX PubMed=18978066; DOI=10.1128/jb.01236-08;
RA Verhamme D.T., Murray E.J., Stanley-Wall N.R.;
RT "DegU and Spo0A jointly control transcription of two loci required for
RT complex colony development by Bacillus subtilis.";
RL J. Bacteriol. 191:100-108(2009).
CC -!- FUNCTION: Required for complex colony architecture.
CC {ECO:0000269|PubMed:17590234}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-
CC ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
CC -!- INDUCTION: Up-regulated by DegU and Spo0A. Repressed by AbrB.
CC {ECO:0000269|PubMed:17590234}.
CC -!- DISRUPTION PHENOTYPE: Overall loss in complex colony architecture and
CC lack of fruiting body-like structures. {ECO:0000269|PubMed:17590234}.
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DR EMBL; AF017113; AAC67301.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB15490.1; -; Genomic_DNA.
DR EMBL; Z94043; CAB08070.1; -; Genomic_DNA.
DR PIR; B70031; B70031.
DR RefSeq; NP_391365.1; NC_000964.3.
DR RefSeq; WP_003244157.1; NZ_JNCM01000033.1.
DR AlphaFoldDB; O06965; -.
DR STRING; 224308.BSU34850; -.
DR PaxDb; O06965; -.
DR PRIDE; O06965; -.
DR EnsemblBacteria; CAB15490; CAB15490; BSU_34850.
DR GeneID; 936576; -.
DR KEGG; bsu:BSU34850; -.
DR PATRIC; fig|224308.179.peg.3773; -.
DR eggNOG; ENOG50331MZ; Bacteria.
DR OMA; KPKDMDP; -.
DR PhylomeDB; O06965; -.
DR BioCyc; BSUB:BSU34850-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Lipoprotein; Membrane; Palmitate; Reference proteome;
KW Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT CHAIN 19..241
FT /note="Putative lipoprotein YvcA"
FT /id="PRO_0000360752"
FT REGION 22..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..49
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 19
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT LIPID 19
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ SEQUENCE 241 AA; 27871 MW; 3E20BA946C36ABC8 CRC64;
MKKIIFICFS LLLALTGGCS MNDNDKNSTN DNKTEAVKPK DMDPKDLPQV PAFQDEKTRE
YMVSTKEEEP GYYLLESKLK GFRMLFPEDG KYLSRRSSLT GKNKESIGFN SYDKDTNVMF
DGHVTYYKEE SFANEPKTML DIVSGKNDYK GEYKKSSKKK TDIYTAKKKD IFDDIDRKYN
YSYSYFGYVK STEEDNLGVE YAFTLGCKNE NQPCSLDEEK AKNKVEKLIN SITFLIDKKE
K
