CC070_MOUSE
ID CC070_MOUSE Reviewed; 248 AA.
AC Q6GQU0; Q8C8Z2;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=UPF0524 protein C3orf70 homolog;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Retina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in neuronal and neurobehavioral development.
CC {ECO:0000250|UniProtKB:Q1LY84}.
CC -!- SIMILARITY: Belongs to the UPF0524 family. {ECO:0000305}.
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DR EMBL; AK044207; BAC31815.1; -; mRNA.
DR EMBL; BC072629; AAH72629.1; -; mRNA.
DR CCDS; CCDS28062.1; -.
DR RefSeq; NP_001001881.1; NM_001001881.2.
DR AlphaFoldDB; Q6GQU0; -.
DR STRING; 10090.ENSMUSP00000062303; -.
DR PhosphoSitePlus; Q6GQU0; -.
DR MaxQB; Q6GQU0; -.
DR PaxDb; Q6GQU0; -.
DR PRIDE; Q6GQU0; -.
DR Antibodypedia; 52632; 40 antibodies from 11 providers.
DR Ensembl; ENSMUST00000053336; ENSMUSP00000062303; ENSMUSG00000043391.
DR GeneID; 72190; -.
DR KEGG; mmu:72190; -.
DR UCSC; uc007yrl.2; mouse.
DR MGI; MGI:1919440; 2510009E07Rik.
DR VEuPathDB; HostDB:ENSMUSG00000043391; -.
DR eggNOG; ENOG502QQSJ; Eukaryota.
DR GeneTree; ENSGT00390000006618; -.
DR HOGENOM; CLU_081879_0_0_1; -.
DR InParanoid; Q6GQU0; -.
DR OMA; GAHKCPK; -.
DR OrthoDB; 1244564at2759; -.
DR PhylomeDB; Q6GQU0; -.
DR TreeFam; TF328625; -.
DR BioGRID-ORCS; 72190; 4 hits in 74 CRISPR screens.
DR PRO; PR:Q6GQU0; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q6GQU0; protein.
DR Bgee; ENSMUSG00000043391; Expressed in habenula and 247 other tissues.
DR ExpressionAtlas; Q6GQU0; baseline and differential.
DR Genevisible; Q6GQU0; MM.
DR GO; GO:0048512; P:circadian behavior; ISS:UniProtKB.
DR GO; GO:0007399; P:nervous system development; ISS:UniProtKB.
DR InterPro; IPR029670; UPF0524_fam.
DR PANTHER; PTHR31785; PTHR31785; 1.
DR Pfam; PF15823; UPF0524; 1.
PE 2: Evidence at transcript level;
KW Neurogenesis; Reference proteome.
FT CHAIN 1..248
FT /note="UPF0524 protein C3orf70 homolog"
FT /id="PRO_0000319977"
FT REGION 169..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..222
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..248
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 114
FT /note="L -> H (in Ref. 1; BAC31815)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 248 AA; 27476 MW; 8FB3FECFC63F4477 CRC64;
MSAATAPERG WKSEKVDEAQ ALARSCAARR PDFQPCDGLS ICATHSHGKC FKLHWCCHLG
WCHCKYVYQP MTPVEQLPST EIPAKPREPT NTIQISVSLT EHFLKFASVF QPPLPPDSPR
YCMISDLFID NYQVKCINGK MCYVQKQQAP HSQKMSPEEV SAHDALISKE SDTPKLGHCS
SPSGSEDSGI NAIGAHYVES CDEDTEEGAE LSSEEDYSPE SSWEPDECTL LSPSQSDLEV
IETMETTV
