ID   CC080_HUMAN             Reviewed;         247 AA.
AC   F5H4A9; Q8N5S4;
DT   19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Uncharacterized membrane protein C3orf80;
DE   Flags: Precursor;
GN   Name=C3orf80;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA   Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA   Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA   Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA   Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA   Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA   Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA   Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA   Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA   Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA   Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA   Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA   Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA   Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA   Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 70-247.
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AC112641; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC031660; AAH31660.1; -; mRNA.
DR   CCDS; CCDS54667.1; -.
DR   RefSeq; NP_001161686.1; NM_001168214.1.
DR   AlphaFoldDB; F5H4A9; -.
DR   IntAct; F5H4A9; 2.
DR   GlyGen; F5H4A9; 1 site.
DR   iPTMnet; F5H4A9; -.
DR   PhosphoSitePlus; F5H4A9; -.
DR   BioMuta; C3orf80; -.
DR   jPOST; F5H4A9; -.
DR   MassIVE; F5H4A9; -.
DR   PaxDb; F5H4A9; -.
DR   PeptideAtlas; F5H4A9; -.
DR   PRIDE; F5H4A9; -.
DR   ProteomicsDB; 26516; -.
DR   Antibodypedia; 50240; 4 antibodies from 4 providers.
DR   DNASU; 401097; -.
DR   Ensembl; ENST00000326474.5; ENSP00000313324.3; ENSG00000180044.6.
DR   GeneID; 401097; -.
DR   KEGG; hsa:401097; -.
DR   MANE-Select; ENST00000326474.5; ENSP00000313324.3; NM_001168214.2; NP_001161686.1.
DR   UCSC; uc021xgp.2; human.
DR   CTD; 401097; -.
DR   GeneCards; C3orf80; -.
DR   HGNC; HGNC:40048; C3orf80.
DR   HPA; ENSG00000180044; Tissue enhanced (brain, esophagus, intestine).
DR   neXtProt; NX_F5H4A9; -.
DR   OpenTargets; ENSG00000180044; -.
DR   VEuPathDB; HostDB:ENSG00000180044; -.
DR   eggNOG; ENOG502S2DR; Eukaryota.
DR   GeneTree; ENSGT00390000005823; -.
DR   HOGENOM; CLU_1363090_0_0_1; -.
DR   InParanoid; F5H4A9; -.
DR   OMA; TEVKCCK; -.
DR   OrthoDB; 1385214at2759; -.
DR   PhylomeDB; F5H4A9; -.
DR   TreeFam; TF337543; -.
DR   PathwayCommons; F5H4A9; -.
DR   BioGRID-ORCS; 401097; 8 hits in 1011 CRISPR screens.
DR   GenomeRNAi; 401097; -.
DR   Pharos; F5H4A9; Tdark.
DR   PRO; PR:F5H4A9; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; F5H4A9; protein.
DR   Bgee; ENSG00000180044; Expressed in endothelial cell and 111 other tissues.
DR   ExpressionAtlas; F5H4A9; baseline and differential.
DR   Genevisible; F5H4A9; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR031696; DUF4719.
DR   PANTHER; PTHR38505; PTHR38505; 1.
DR   Pfam; PF15843; DUF4719; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..35
FT                   /evidence="ECO:0000255"
FT   CHAIN           36..247
FT                   /note="Uncharacterized membrane protein C3orf80"
FT                   /id="PRO_0000413691"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          109..179
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        57
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   247 AA;  25682 MW;  2EA426CB6B95DC9B CRC64;
     MWGPGVTAEG LSVAPAPPPL LPLLLLLALA LVAPSRGGGG CAELACGERE RCCDATNATA
     VRCCKLPLHA FLDNVGWFVR KLSGLLILLV LFAIGYFLQR IICPSPRRYP RGQARPGQRP
     GPPGGAGPLG GAGPPDDDDD SPALLRDEAA AGSQDSLLDS GGGGRGRGGG GRSDPSCASE
     HEMRVVSPVF LQLPSYEEVK YLPTYEESMR LQQLSPGEVV LPVSVLGRPR GGVAAEPDGG
     EGRYPLI